Mean Platelet Volume a Marker for Bleeding Risk : A Prospective Study among Sudanese Patients with Dengue Virus Infection = متوسط حجم الصفيحة الدموية علامة لمخاطر النزيف : دراسة على الأثر المتوقع على المرضى السودانيين المصابين بحمى الضنك

2018 ◽  
Vol 54 (1) ◽  
pp. 15-20
Author(s):  
Bashir A. B. Mohammed
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Prospective Study ◽  
Mean Platelet Volume ◽  
Bleeding Risk ◽  
Platelet Volume ◽  
Dengue Virus Infection ◽  
A Prospective Study

scholarly journals Dengue virus infection among long-term travelers from the Netherlands: A prospective study, 2008-2011

PLoS ONE ◽  
2018 ◽  
Vol 13 (2) ◽  
pp. e0192193 ◽  
Author(s):  
Femke W. Overbosch ◽  
Janke Schinkel ◽  
Ineke G. Stolte ◽  
Maria Prins ◽  
Gerard J. B. Sonder
Keyword(s):  
Virus Infection ◽  
The Netherlands ◽  
Dengue Virus ◽  
Prospective Study ◽  
Dengue Virus Infection ◽  
A Prospective Study

scholarly journals 2309. Could Mean Platelet Volume Predict Platelet Count Recovery in Dengue Virus Infection?

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S791-S791
Author(s):  
Ana M Sanz ◽  
Diana M Martinez ◽  
Andrea Valencia ◽  
Liliana Flórez ◽  
Diego Tovar ◽  
...  
Keyword(s):  
Platelet Count ◽  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Fever ◽  
Clinical Data ◽  
Mean Platelet Volume ◽  
Blood Count ◽  
Platelet Volume ◽  
Dengue Virus Infection ◽  
Count Recovery

Abstract Background Dengue fever, a major public health problem throughout tropical and subtropical regions, has often unpredictable clinical evolution and outcomes. Thrombocytopenia is a common laboratory finding in dengue fever and severe dengue during the dengue critical phase. To the best of our knowledge, there is no clinical data about patient and disease factors that could predict in a short time the platelet recovery. Mean platelet volume (MPV), a measurement of platelet size, has a strong inverse correlation with platelet count and could indirectly reflect bone marrow activity. The aim of this study was to describe the behavior of MPV during the platelet count nadir and recovery. Methods An observational prospective study was conducted. We included patients with confirmed dengue virus infection with SD BIOLINE Dengue Duo kit (Abbott, Santa Clara, USA; former Alere Inc., Waltham, USA) attended at Fundación Valle del Lili, Cali - Colombia. Blood count was analyzed by xn-3000 system impedance method (Sysmex, Kobe, Japan). Laboratory and clinical data were recollected from clinical charts and clinical laboratory database. Platelet count (PC) and MPV were measured repeatedly during clinical management. Time was measured from the first blood count. A non-parametric analysis with a cubic smoothing spline was performed for platelet count and MPV. Results A total of 54 patients were analyzed from April 2016 to January 2016. 50% of patients had at least three blood counts. The median of the lowest PC was 112,500/L (IQR = 67,000–148,500), and the median of the highest MPV was 11. 25 fL (IQR = 10. 42–12. 15). MPV increased from the first blood count until day six, while platelets presented slight fluctuations. On the sixth day after first blood count, MPV presented a high peak that suggests an inverse relationship with a platelets decrease (Figure 1). Conclusion MPV increased with thrombocytopenia during the critical period and its decline precedes platelet count recovery. MPV could be useful to predict the platelet count recovery. Disclosures All authors: No reported disclosures.

Dengue virus infection in haemophilic patients: aggravation of bleeding risk

Haemophilia ◽  
2010 ◽  
Vol 17 (3) ◽  
pp. 553-556 ◽  
Author(s):  
A. CHUANSUMRIT ◽  
K. TANGNARARATCHAKIT ◽  
N. SIRACHAINAN ◽  
A. KHOSITSETH ◽  
T. KUPTANON ◽  
...  
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Bleeding Risk ◽  
Dengue Virus Infection

scholarly journals Significance of APTT as early predictor of bleeding in comparison to thrombocytopenia in dengue virus infection

2018 ◽  
Vol 7 (1) ◽  
pp. 67
Author(s):  
Hamsa B. T. ◽  
Srinivasa S. V. ◽  
Prabhakar K. ◽  
Raveesha A. ◽  
Manoj A. G.
Keyword(s):  
Virus Infection ◽  
Dengue Virus ◽  
Dengue Fever ◽  
Platelet Transfusion ◽  
Dengue Virus Infection ◽  
Daily Monitoring ◽  
Hospital Patients ◽  
Prolonged Aptt ◽  
Bleeding Manifestation ◽  
A Prospective Study

Background: Dengue is a systemic viral infection transmitted by mosquitoes such as Aedes aegypti or Aedes albopictus. Dengue Fever (DF) is characterized by fever, headache, muscle or joint pain, and rash. The spectrum of dengue virus infection spreads from an undifferentiated fever and dengue fever (DF) to dengue haemorrhagic fever (DHF) with shock. Factors responsible for bleeding manifestations in dengue are vasculopathy, thrombocytopenia, coagulopathy, and disseminated intravascular coagulation (DIC). Coagulopathy results in derangement of activated partial thromboplastin time (APTT) which is an indicator of impending bleeding risk.Methods: A prospective study was conducted from June to December in 2017 in R L Jalappa Hospital. Patients aged above 18 years with febrile thrombocytopenia who are positive for dengue virus serology (NS1Ag and/ or IgM) were included in the study. Serial daily monitoring of platelet count and analysis of APTT levels were done. APTT was considered abnormal if it was more than 33.8s. Patients were followed up for evidence of leaking and bleeding manifestations.Results: Out of 170 patients 28.1% patients had bleeding manifestations. Bleeding signs were seen on clinical examination in 52.37% of patients. capillary leak was found in the form of Pleural effusion in 35.3%, Ascites in 41.2% and Periorbital edema in 31.2% of patients. Elevated APTT levels were seen in 110(64.7%) patients. Among patients with abnormal APTT platelet transfusion was done in 78.9% of patients, and among those with normal APTT levels platelet transfusion was done in 21.1% of patients.Conclusions: Our study showed significant correlation between bleeding manifestations and prolonged APTT levels as well as thrombocytopenia with abnormal APTT levels. Study concluded that 21.1% of platelet transfusions could have been prevented considering prolonged APTT as a predictor of bleeding manifestation, thus saving the resources and reactions due to platelet concentrate transfusion.

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