Granulocyte-Colony Stimulating Factor Prevents Motor Dysfunction and Histological Damages in a Rat Model of Parkinson's Disease

2017 ◽  
Vol 69 (1) ◽  
pp. 1628-1633
Author(s):  
Mariama S. Azmy ◽  
Esther T. Menze ◽  
Reem N. El-Naga
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rat Model ◽  
Motor Dysfunction ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

scholarly journals Neuroprotection of Granulocyte Colony-Stimulating Factor for Early Stage Parkinson's Disease

2017 ◽  
Vol 26 (3) ◽  
pp. 409-416 ◽  
Author(s):  
Sheng-Tzung Tsai ◽  
Sung-Chao Chu ◽  
Shu-Hsin Liu ◽  
Cheng-Yoong Pang ◽  
Ting-Wen Hou ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rating Scale ◽  
Early Stage ◽  
In Vivo Studies ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Elevated Liver Enzymes ◽  
Stimulating Factor

Parkinson's disease (PD) is a slowly progressive neurodegenerative disease. Both medical and surgical choices provide symptomatic treatment. Granulocyte colony-stimulating factor (G-CSF), a conventional treatment for hematological diseases, has demonstrated its effectiveness in acute and chronic neurological diseases through its anti-inflammatory and antiapoptosis mechanisms. Based on previous in vitro and in vivo studies, we administered a lower dose (3.3 μg/kg) G-CSF injection for 5 days and six courses for 1 year in early-stage PD patients as a phase I trial. The four PD patient's mean unified PD rating scale motor scores in medication off status remained stable from 23 before the first G-CSF injection to 22 during the 2-year follow-up. 3,4-Dihydroxy-6-18F-fluoro-L-phenylalanine (18F-DOPA) positron emission tomography (PET) studies also revealed an annual 3.5% decrease in radiotracer uptake over the caudate nucleus and 7% in the putamen, both slower than those of previous reports of PD. Adverse effects included transient muscular–skeletal pain, nausea, vomiting, and elevated liver enzymes. Based on this preliminary report, G-CSF seems to alleviate disease deterioration for early stage PD patients. The effectiveness of G-CSF was possibly due to its amelioration of progressive dopaminergic neuron degeneration.

scholarly journals Pegylated granulocyte colony-stimulating factor conveys long-term neuroprotection and improves functional outcome in a model of Parkinson’s disease

Brain ◽  
2012 ◽  
Vol 135 (6) ◽  
pp. 1914-1925 ◽  
Author(s):  
Tobias Frank ◽  
Florian Klinker ◽  
Björn H. Falkenburger ◽  
Rico Laage ◽  
Fred Lühder ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Functional Outcome ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

scholarly journals Granulocyte-colony stimulating factor is neuroprotective in a model of Parkinson's disease

2006 ◽  
Vol 97 (3) ◽  
pp. 675-686 ◽  
Author(s):  
Katrin Meuer ◽  
Claudia Pitzer ◽  
Peter Teismann ◽  
Carola Krüger ◽  
Bettina Göricke ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor

Granulocyte-colony stimulating factor (G-CSF) enhances recovery in mouse model of Parkinson's disease

2011 ◽  
Vol 487 (2) ◽  
pp. 153-157 ◽  
Author(s):  
Shijie Song ◽  
Vasyl Sava ◽  
Amanda Rowe ◽  
Kunyu Li ◽  
Chuanhai Cao ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Mouse Model ◽  
Granulocyte Colony Stimulating Factor ◽  
Colony Stimulating Factor ◽  
Stimulating Factor ◽  
Factor G

Granulocyte-Macrophage Colony-Stimulating Factor mRNA and Neuroprotective Immunity in Parkinson’s Disease

Biomaterials ◽  
2021 ◽  
pp. 120786
Author(s):  
Katherine E. Olson ◽  
Krista L. Namminga ◽  
Yaman Lu ◽  
Mackenzie J. Thurston ◽  
Aaron D. Schwab ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Colony Stimulating Factor ◽  
Macrophage Colony Stimulating Factor ◽  
Macrophage Colony ◽  
Stimulating Factor
Sign in / Sign up

Export Citation Format

Share Document