Effect of Amniotic Membrane Transplantation in Recurrent Pterygium Surgery

2017 ◽  
Vol 23 ◽  
pp. 1-5
Author(s):  
Ahmed Tamer Sayed Seif ◽  
Noha Mahmoud Khalil
Keyword(s):  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Recurrent Pterygium ◽  
Pterygium Surgery

scholarly journals A randomized clinical trial of freeze-dried amniotic membrane transplantation and conjunctival-limbal graft for pterygium excision and evaluation of conjunctival inflammation marker in tears

2020 ◽  
Vol 29 (4) ◽  
pp. 359-65
Author(s):  
Made Susiyanti ◽  
Manoa Panjaitan ◽  
Grace Wangge ◽  
Tjahjono Darminto Gondhowiardjo
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Freeze Dried ◽  
Conjunctival Inflammation ◽  
Recurrent Pterygium ◽  
Pterygium Surgery ◽  
Pterygium Excision

BACKGROUND Minimizing inflammation on the ocular surface after pterygium surgery is essential to prevent recurrence. Currently, limited data are available for the comparison between freeze-dried amniotic membrane (FD-AM) and conjunctival–limbal graft (CLG). Therefore, this study aimed to assess conjunctival inflammation and the interleukin (IL)-6 levels in tears after pterygium excision between both techniques. METHODS This prospective, single-blinded, randomized clinical trial included 26 eyes of 26 patients with primary or recurrent pterygium and who were indicated for pterygium surgery at Cipto Mangunkusumo Hospital, Indonesia from October 2017 until February 2018. The patients were scheduled for pterygium excision with FD-AM or CLG based on block randomization. Conjunctival inflammation and the level of IL-6 in tears were measured on day-7 and -28 after surgery. RESULTS The 26 eyes (13 in each group) were subjected to a complete 1-month follow-up period. Day-7 after the surgery, severe inflammation occurred in 4/13 (31%) eyes having FD-AM and 8/13 eyes (62%) having CLG (p = 0.59). The IL-6 tear level increased similarly in FD-AM (22.85 pg/ml) and CLG (23.51 pg/ml) in (p = 0.78). No severe adverse events occurred. CONCLUSIONS Pterygium excision using FD-AM yield a milder inflammation than CLG on day-7 and -28 after surgery. The tear IL-6 levels similarly increased on day-7.

Amniotic Membrane Transplantation with Narrow-Strip Conjunctival Autograft vs Conjunctival Autograft for Recurrent Pterygia

2016 ◽  
Vol 27 (2) ◽  
pp. 135-140 ◽  
Author(s):  
José B. Barbosa ◽  
Charles Costa De Farias ◽  
Flávio E. Hirai ◽  
José Á. Pereira Gomes
Keyword(s):  
Amniotic Membrane ◽  
Amniotic Membrane Transplantation ◽  
Patient Age ◽  
Narrow Strip ◽  
Conjunctival Autograft ◽  
Significant Difference ◽  
Recurrent Pterygium ◽  
Group 2 ◽  
Grade 3 ◽  
Group 1

Purpose To compare amniotic membrane transplantation (AMT) associated with narrow-strip conjunctival autograft vs conjunctival autograft alone for the treatment of recurrent pterygium. Methods In this prospective consecutive interventional study, patients with recurrent pterygium were randomly divided into one of 2 groups; group 1: patients undergoing AMT associated with autologous conjunctival graft; and group 2: patients undergoing conjunctival autograft alone. Results Of the 80 operated eyes included in this study, 39 (group 1, mean patient age 52.1 ± 11.7 SD years) underwent AMT associated with narrow-strip conjunctival autograft and 41 (group 2, mean patient age 45.8 ± 12.9 SD years) underwent conjunctival autograft alone. In group 1, 6 eyes (15.4%) had grade 1 pterygium, 19 eyes (48.7%) had grade 2 pterygium, and 14 eyes (35.9%) had grade 3 pterygium. In the second group, 5 eyes (12.2%) had grade 1 pterygium, 18 eyes (43.9%) had grade 2 pterygium, and 14 eyes (35.9%) had grade 3 pterygium. No statistically significant difference was found between the 2 groups (p = 0.752). Of the 39 eyes in group 1, recurrent pterygium was observed in 7 cases (17.9%). However, of the 41 eyes in group 2, recurrent pterygium was observed in only 4 cases (9.75%). No statistically significant difference was found between the 2 groups (p = 0.2684). Conclusions The results of this study indicate that conjunctival autograft alone might be a better surgical choice for the treatment of recurrent pterygia than combining it with AMT; however, this second option provides a good surgical alternative in cases where little conjunctival donor tissue is available.

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