Effects of Some Food Additives on Some Biochemical Parameters in Young Male Albino Rats and the Ameliorative Role of Royal Jelly

2017 ◽  
Vol 67 (2) ◽  
pp. 605-613 ◽  
Author(s):  
Eman G. E. Helal ◽  
Rasha A. A. El-Sayed ◽  
Gomaa Mostafa Hedeab
Keyword(s):  
Biochemical Parameters ◽  
Royal Jelly ◽  
Food Additives ◽  
Young Male ◽  
Albino Rats

scholarly journals Ameliorative Effects of Honey, Propolis, Pollen, and Royal Jelly Mixture against Chronic Toxicity of Sumithion Insecticide in White Albino Rats

Molecules ◽  
2020 ◽  
Vol 25 (11) ◽  
pp. 2633 ◽  
Author(s):  
Atef M.K. Nassar ◽  
Yehia M.M. Salim ◽  
Khalid S.A. Eid ◽  
Hazem M. Shaheen ◽  
Abdullah A. Saati ◽  
...  
Keyword(s):  
Royal Jelly ◽  
Corn Oil ◽  
Ethylenediaminetetraacetic Acid ◽  
Reproductive Organs ◽  
Protective Role ◽  
Albino Rats ◽  
Total Protein Content ◽  
Glutathione S Transferase ◽  
Significant Toxicity

Sumithion (Fenitrothion) (SUM) is an organophosphorus insecticide used to combat a wide variety of plant pests. Exposure to SUM causes significant toxicity to the brain, liver, kidney, and reproductive organs through, for example, binding to DNA, and it induces DNA damage, which ends with oxidative stress. Therefore, the present study aimed to examine the protective role of bee products: a mixture of honey, propolis, palm pollen, and royal jelly (HPPJ) against SUM-induced toxicity. Twenty-four male albino rats (Rattus norvegicus) were classified into four groups, each containing six rats: control (corn oil), SUM (85 mg/kg; 1/20 LD50), HPPJ, and SUM + HPPJ once daily for 28 consecutive days. Blood samples were gently collected in sterilized ethylenediaminetetraacetic acid (EDTA) tubes for blood picture analyses and tubes without anticoagulant for serum isolation. Serum was used for assays of enzymatic and biochemical characteristics. The results revealed that SUM increased the weights of the liver, kidney, and brain as well as the enzymatic activity of glutathione peroxidase (GP), serum superoxide dismutase (SOD), and glutathione-S-transferase (GST). Additionally, SUM significantly increased the activity of lactate dehydrogenase (LDH), alkaline phosphatase (ALP), and γ-glutamyltransferase (γ-GT) and glucose, uric acid, and creatinine contents, while decreasing the acetylcholine esterase (AChE) activity and total lipids and total protein content. Furthermore, because of the inclusion of phenolic, flavonoids, terpenoids, and sugars, the HPPJ mixture counteracted the hematological, renal, and hepatic toxicity of SUM exposure.

scholarly journals Adverse Effect of Mixture of Food Additives on Some Biochemical Parameters in Male Albino Rats

2020 ◽  
Vol 13 ◽  
pp. 1-13 ◽  
Author(s):  
Eman Hashem Radwan ◽  
Mohamed Mohamed Elghazaly ◽  
Hussein Khamis Hussein ◽  
Karolin Kamel Abdel Aziz ◽  
Amel Ibrahim Barakat
Keyword(s):  
Antioxidant Enzymes ◽  
Sodium Nitrite ◽  
Sodium Benzoate ◽  
Biochemical Parameters ◽  
Food Additives ◽  
Kidney Tissue ◽  
Activity Level ◽  
Control Group ◽  
Albino Rats ◽  
Significant Activity

The present study investigated the unsafe impacts of sodium nitrite, sodium benzoate and their mixture which is utilized in fabricating of the food on some biochemical parameters in male albino rats. Rats (40) were divided into four groups as follows: group 1 used as the control, group II and III were treated orally with sodium nitrite nano2 (80 mg/kg BW) and sodium benzoate (SB) (200 mg/kg BW), respectively. Group IV was treated orally with a mixture of sodium nitrite and sodium benzoate. Rats took their respective doses every day for 8 weeks. The obtained results showed that sodium nitrite, sodium benzoate and their mixture (nano2 and SB)  initiated a diminished within in the activity of antioxidant enzymes (SOD, CAT, and GSH) within the kidney, while, MDA recorded a highly significant activity level within experimental groups. Urea and creatinine mean levels were were expanded within plasma of the experimental rats. In the histology of the kidney, sections appeared edema with few mononuclear leukocyte cellular infiltrations, shrinkage of glomeruli. The severity of these changes increased in the experimental group which treated by the mixture of sodium nitrite and sodium benzoate. Overexpression in p53 occurred in experimental groups that were treated by nano2, SB and their mixture. The present study concluded that the mixture of food additives can induce toxicity in the kidney of rats. It is obvious that food additives induced nephrotoxicity  within the kidney. It decreased the antioxidant enzymes (GSH, CAT, and SOD) and increased MDA. Increase tumor suppressor gene p53 in kidney tissue. Food added substances caused changes in biochemical parameters as in creatinine and urea. The utilization of food additives must be decreased. The presence of more than one type of food additives on our food and the usage of the mixture of sodium nitrite and sodium benzoate initiated changes in biochemical parameters and immune-histopathological changes.

scholarly journals Copper-induced changes of lipid peroxidation and hemato-biochemical parameters in rat blood: Protective role of flavonoids

2014 ◽  
Vol 66 (3) ◽  
pp. 1271-1279 ◽  
Author(s):  
Jelena Mladenovic ◽  
Milica Paunovic ◽  
Milos Matic ◽  
Veroljub Knezevic ◽  
Branka Ognjanovic ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Lactate Dehydrogenase ◽  
Biochemical Parameters ◽  
Lipid Peroxides ◽  
Protective Role ◽  
Albino Rats ◽  
Biochemical Processes ◽  
Wistar Albino Rats ◽  
Induced Changes

The effects of subchronic exposure to copper (Cu) on lipid peroxidation, hemato-biochemical parameters, and the possible protective role of flavonoids Quercetin and (-)-Epicatechin were studied. Male Wistar albino rats were treated with Cu (560 mg/L, p.o. as CuCl2?2H2O for 5 weeks) and Quercetin and (-)-Epicatechin (40 mg/kg BW each, i.p., every third day during the last 3 weeks) alone or in combination. Cu increased the concentration of lipid peroxides, decreased the number of erythrocytes, hemoglobin and hematocrit values and increased the activities of aspartate aminotransferase, alanine aminotransferase and lactate dehydrogenase. Coadministration of Quercetin and (-)-Epicatechin with Cu lowered the process of lipid peroxidation and restored examined hemato-biochemical parameters to control values. Our results indicate that Cu induced oxidative damage in erythrocytes, which led to anemia, while Quercetin and (-)-Epicatechin showed a protective effect on the hemato-biochemical processes in the blood of rats.

EFFECT OF ETHANOLIC EXTRACT FRACTIONS OF ROSA CENTIFOLIA IN DOXORUBICIN-INDUCED MYOCARDIAL TOXICITY IN ALBINO RATS

INDIAN DRUGS ◽  
2018 ◽  
Vol 55 (12) ◽  
pp. 27-33
Author(s):  
S. K Nimbal ◽  
◽  
B. C Koti
Keyword(s):  
Ethyl Acetate ◽  
Biochemical Parameters ◽  
Troponin I ◽  
Ethanolic Extract ◽  
Ethyl Acetate Fraction ◽  
Repeated Administration ◽  
Albino Rats ◽  
Standard Drug ◽  
Preventive Role

This study was undertaken to understand the preventive role of ethanolic extract fractions of flower petals of Rosa centifolia (RC) against Doxorubicin-induced myocardial toxicity in albino rats. The ethanolic extract of flower petals of RC was prepared by hot extraction method and further fractionated into petroleum ether (PERC), chloroform (CHRC), ethyl acetate (EARC) and aqueous (AQRC) fractions by increasing in order of polarity. Cardiotoxicity was produced by cumulative administration of Dox (2.5 mg/kg alternative day for two weeks). All four fractions (PERC-20 mg/kg, CLRC-15 mg/kg, EARC-40 mg/kg and AQRC-25 mg/kg) were administered as pretreatment for two weeks followed by Dox on alternative days for two weeks. The general observations, biomarker enzymes like lactate dehydrogenase (LDH), creatine kinase (CK-MB) and troponin-I (cTnI), biochemical parameters such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were monitored after three weeks of last dose. Myocardial toxicity was also evaluated by histopathologic studies. Repeated administration of Dox-induced cardiomyopathy was characterized with an increased level of biomarkers and antioxidant deficit. Pretreatment with the EARC (40 mg/kg) and standard drug (Vit-E 100 mg/kg) significantly protected myocardium from the toxic effects of Dox by reducing the elevated level of biomarker enzymes like LDH, CK-MB, biochemical parameters such as AST and ALT, absence of cTnI and restoring of disorganized myocardial tissue to normal. The biomarker, biochemical and histopathological data evidently substantiate the cardioprotective effect of EARC, which could be attributed to flavanoids present in the ethyl acetate fraction.

scholarly journals Toxic Effects of Food azo dye Tartrazine on the Brain of Young Male Albino Rats: Role of Oxidative Stress

2020 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
Nema allah hosieny ◽  
mona eldemerdash ◽  
Samah Ahmed ◽  
Mohammad Zayed
Keyword(s):  
Oxidative Stress ◽  
Azo Dye ◽  
Young Male ◽  
Toxic Effects ◽  
Albino Rats ◽  
The Brain

Potential effect of pharmaceutical care to improve outcomes in patients with chronic kidney disease-mineral bone disorder in Sulaimani dialysis centers

2020 ◽  
pp. 82-94
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Pharmaceutical Care ◽  
Biochemical Parameters ◽  
Positive Impact ◽  
Potential Effect ◽  
Care Group ◽  
Mineral Bone Disorder ◽  
Bone Disorder

Objective: the present study was aimed to evaluate the role of pharmaceutical services in improving the outcome of mineral bone disorder in patients with advanced chronic kidney disease. Methodology: One hundred and twenty patients with chronic kidney disease-mineral bone disorder (CKD-MBD) screened for eligibility, seventy-six patients enrolled in the study and randomly allocated into two groups: pharmaceutical care and usual care, both groups interviewed by the pharmacist using specific questionnaire for assessing the quality of life (QoL). All the drug related problems (DRPs) including drug-drug interactions (DDIs) were recorded by the pharmacist. Blood samples were collected and utilized for analyzing the levels of vitamin D, phosphorous, calcium, albumin and parathyroid hormone at baseline and three months after. The pharmaceutical care group received all the educations about their medications and how to minimize DRPs; improve the QoL. Additionally, the pharmaceutical intervention included correcting the biochemical parameters. Results: Pharmaceutical care significantly improved patients QoL and minimized DRPs and DDIs. It was also effective in improving the biochemical parameters. Conclusion: Pharmaceutical care has a positive impact on improving the outcome of patients with CKD-MBD through attenuating DRPs, improving the biochemical parameters and the QoL.

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