Clinical Presentation of Polycystic Ovary Syndrome among Saudi Arabian Women - Jeddah, Saudi Arabia

2017 ◽  
Vol 67 (1) ◽  
pp. 494-498
Author(s):  
Najla Abdullahh Alsibyani ◽  
Mohammed A. Malibary ◽  
Ahmad Ayed Derham
Keyword(s):  
Saudi Arabia ◽  
Polycystic Ovary Syndrome ◽  
Clinical Presentation ◽  
Polycystic Ovary ◽  
Saudi Arabian ◽  
Ovary Syndrome

scholarly journals CLINICAL PRESENTATION OF POLYCYSTIC OVARY SYNDROME AMONG SAUDI ARABIAN WOMEN – JEDDAH – SAUDI ARABIA.

2017 ◽  
Vol 5 (3) ◽  
pp. 1872-1876 ◽  
Author(s):  
NajlaAbdullahh Alsibyani ◽  
◽  
MohammedA Malibary ◽  
AhmadAyed Derham ◽  
AbdulrahmanAbdulelah Almnabri ◽  
...  
Keyword(s):  
Saudi Arabia ◽  
Polycystic Ovary Syndrome ◽  
Clinical Presentation ◽  
Polycystic Ovary ◽  
Saudi Arabian ◽  
Ovary Syndrome

scholarly journals MULTIPLE APPROACHES IN AYURVEDA FOR PATHO-PHYSIOLOGY IN POLYCYSTIC OVARIAN SYNDROME

2021 ◽  
Vol 10 (3) ◽  
pp. 3055-3058
Author(s):  
R Andhare
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Polycystic Ovarian Syndrome ◽  
Clinical Presentation ◽  
Polycystic Ovary ◽  
Modern Science ◽  
Metabolic Function ◽  
Complete Understanding ◽  
Ovary Syndrome ◽  
Menstrual Dysfunction ◽  
Ovarian Syndrome

The most prevalent endocrine condition in women is polycystic ovary syndrome (pcos).the clinical presentation of pcos ranges between mild menstrual dysfunction and extreme reproductive and metabolic function disruption. According to modern science, the physiology related to ovulation is controlled by hormones of hypothalamo – pituitary – ovarian axis. This axis is disturbed in pcos. According to ayurveda, patho-physiology involves vitiated doshas i.e. Vata, pitta, kapha and agni – especially dhatwagni. The pathophysiology of pcos is analysed to clarify the precise cause of the disorder in order to prepare therapy for a full cure. Multiple approaches in ayurveda for patho-physiology in polycystic ovarian syndrome. It is evident in conclusion that pcos is an enigma. There is no complete understanding of its fundamental pathophysiology as per modern science. No therapy is a panacea, as therapies have so far been targeted at the symptoms but not at the syndrome itself.

Adiponectin (ADIPOQ) gene variants and haplotypes in Saudi Arabian women with polycystic ovary syndrome (PCOS): a case–control study

2019 ◽  
Vol 36 (1) ◽  
pp. 66-71
Author(s):  
Intissar Ezzidi ◽  
Nabil Mtiraoui ◽  
Mohammed Eltigani Mohmmed Ali ◽  
Aqeel Al Masoudi ◽  
Faisel Abu Duhier
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Saudi Arabian ◽  
Case Control ◽  
Gene Variants ◽  
Ovary Syndrome ◽  
Adipoq Gene ◽  
Control Study

An evaluation of the chronology and frequency of the symptomatology during polycystic ovary syndrome (PCOS) patients’ initial clinical presentation

2002 ◽  
Vol 78 ◽  
pp. S279-S280
Author(s):  
Michael Haim Dahan ◽  
Song Nguyen ◽  
Iroso Abu ◽  
Richard Y Yoo ◽  
Ketan S Patel ◽  
...  
Keyword(s):  
Polycystic Ovary Syndrome ◽  
Clinical Presentation ◽  
Polycystic Ovary ◽  
Ovary Syndrome

scholarly journals Epigenetic Modification of the X Chromosome Influences Susceptibility to Polycystic Ovary Syndrome

2006 ◽  
Vol 91 (7) ◽  
pp. 2789-2791 ◽  
Author(s):  
T. E. Hickey ◽  
R. S. Legro ◽  
R. J. Norman
Keyword(s):  
Polycystic Ovary Syndrome ◽  
X Chromosome ◽  
Null Hypothesis ◽  
Clinical Presentation ◽  
Outcome Measure ◽  
Polycystic Ovary ◽  
Epigenetic Modification ◽  
Polymorphic Locus ◽  
Ovary Syndrome ◽  
Genetic Studies

Abstract Context: The cause of polycystic ovary syndrome (PCOS) is unknown, although genetic and environmental influences are clearly implicated. Some genetic studies have suggested the involvement of X-linked genes in PCOS, but the influence of X chromosome inactivation (XCI) on manifestation of this disorder has not previously been examined. Objective: The objective of the study was to test the null hypothesis that XCI has no influence on clinical presentation of PCOS. Design: We examined patterns of XCI between sister pairs with the same genotype at a polymorphic locus on the X chromosome in families with PCOS. Setting: The study was conducted at a private practice. Participants: PCOS was defined as hyperandrogenemia with chronic anovulation. Forty families were studied in which DNA was obtained from at least one parent, the proband, and one sister that could be accurately diagnosed as being affected or unaffected. Main Outcome Measure(s): Relative expression of two X-linked alleles was determined, and the ratio of one to the other represented the pattern of XCI. Results: The statistical odds on a different clinical presentation between sisters was approximately 29 times higher in sister pairs with different patterns of XCI, compared with sister pairs with the same pattern of XCI (odds ratio 28.9; 95% confidence interval 4.0–206; P = 0.0008). Conclusions: This study provides evidence to refute the null hypothesis and propose a closer inspection of X-linked genes in PCOS, one in which both genotype and epigenotype are considered. Environmental determinants of PCOS may alter clinical presentation via epigenetic modifications, which currently remain undetected in traditional genetic analyses.

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