Pharmacological Effects of Gemfibrozil on Some Isolated Smooth Muscle Preparations of Experimental Animals

2017 ◽  
Vol 66 ◽  
pp. 1-17
Author(s):  
Fatma Sabry El Makkawy ◽  
Azza Mohammed Ezzo ◽  
Enass Abd El-Aty Ouda
Keyword(s):  
Smooth Muscle ◽  
Pharmacological Effects ◽  
Experimental Animals

Purification, subunit structure and pharmacological effects on cardiac and smooth muscle cells of a polypeptide toxin isolated from the marine snail Conus tessulatus

1986 ◽  
Vol 161 (3) ◽  
pp. 787-792 ◽  
Author(s):  
Hugues SCHWEITZ ◽  
Jean-Francois RENAUD ◽  
Nicole RANDIMBIVOLOLONA ◽  
Catherine PREAU ◽  
Annie SCHMID ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Subunit Structure ◽  
Pharmacological Effects ◽  
Marine Snail

Pharmacological Effects of Berberine and Palmatine on the Prostatic and Urethral Smooth Muscle of the Rabbit

2002 ◽  
Vol 6 (2) ◽  
pp. 62 ◽  
Author(s):  
Seung-June Oh ◽  
Jeongyoon Kang ◽  
Jeong Yun Jeong ◽  
Kyung Hoon Lee ◽  
Sung Joon Kim ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pharmacological Effects ◽  
Urethral Smooth Muscle

In-vitro characterization of the pharmacological effects induced by (–)-α-bisabolol in rat smooth muscle preparations

2012 ◽  
Vol 90 (1) ◽  
pp. 23-35 ◽  
Author(s):  
Rodrigo J.B. de Siqueira ◽  
Walter B.S. Freire ◽  
Alfredo A. Vasconcelos-Silva ◽  
Patrícia A. Fonseca-Magalhães ◽  
Francisco J.B. Lima ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Urinary Bladder ◽  
Biologically Active ◽  
Pharmacological Effects ◽  
Bladder Tissue ◽  
In Vitro Characterization ◽  
Voltage Dependent ◽  
Spontaneous Contractions

The present study deals with the pharmacological effects of the sesquiterpene alcohol (–)-α-bisabolol on various smooth-muscle preparations from rats. Under resting tonus, (–)-α-bisabolol (30–300 µmol/L) relaxed duodenal strips, whereas it showed biphasic effects in other preparations, contracting endothelium-intact aortic rings and urinary bladder strips, and relaxing these tissues at higher concentrations (600–1000 µmol/L). In preparations precontracted either electromechanically (by 60 mmol/L K+) or pharmacomechanically (by phenylephrine or carbachol), (–)-α-bisabolol showed only relaxing properties. The pharmacological potency of (–)-α-bisabolol was variable, being higher in mesenteric vessels, whereas it exerted relaxing activity with a lesser potency on tracheal or colonic tissues. In tissues possessing spontaneous activity, (–)-α-bisabolol completely decreased spontaneous contractions in duodenum, whereas it increased their amplitude in urinary bladder tissue. Administered in vivo, (–)-α-bisabolol attenuated the increased responses of carbachol in tracheal rings of ovalbumin-sensitized rats challenged with ovalbumin, but was without effect in the decreased responsiveness of urinary bladder strips in mice treated with ifosfamide. In summary, (–)-α-bisabolol is biologically active in smooth muscle. In some tissues, (–)-α-bisabolol preferentially relaxed contractions induced electromechanically, especially in tracheal smooth muscle. The findings from tracheal rings reveal that (–)-α-bisabolol may be an inhibitor of voltage-dependent Ca2+ channels.

scholarly journals Вплив психотропних лікарських засобів на спонтанну поведінкову актиність білих щурів

2011 ◽  
Vol 2 (1) ◽  
pp. 47-53
Author(s):  
A. L. Drozdov ◽  
E. M. Demchenko ◽  
A. Ejjyad ◽  
O. P. Nerush
Keyword(s):  
Clinical Practice ◽  
Atypical Antipsychotic ◽  
Antipsychotic Drug ◽  
Mental Disability ◽  
Pharmacological Effects ◽  
Treatment Optimization ◽  
Atypical Antipsychotic Drug ◽  
Experimental Animals ◽  
Nootropic Agents ◽  
Experimental Psychosis

Data obtained showed that using of neuroleptics in conditions of experimental psychosis was accompanied by the decreasing of mobility, investigative behavior and emotionality in experimental animals more than in intact ones. Asopposed to that, the action of atypical antipsychotic drug – sulpiride was characterized by the anxiety decreasing but the mobility increasing. The nootropic agents resulted in increasing of motor and emotional activity. The established pharmacological effects of neuroleptics, antidepressants and nootropic agents may use in clinical practice for treatment optimization of the patients with mental disability including schizophrenia.

Pharmacological Effects of Peptides on Tracheal Smooth Muscle

Pharmacology ◽  
1982 ◽  
Vol 25 (1) ◽  
pp. 39-50 ◽  
Author(s):  
J. Mizrahi ◽  
R. Couture ◽  
S. Caranikas ◽  
D. Regoli
Keyword(s):  
Smooth Muscle ◽  
Tracheal Smooth Muscle ◽  
Pharmacological Effects
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