Effect of pH , Temperature and Monomer Mole Ratios on the Swelling Properties of Polyethylene Oxide-Polymethacrylic Acid-Polyacrylamide ( PEO-PMAA-PAAM ) Interpolymer Complex ( IPC )

2015 ◽  
Vol 10 (2) ◽  
pp. 119-129
Author(s):  
Raid Banat
2014 ◽  
Vol 11 (1) ◽  
pp. 205-209 ◽  
Author(s):  
S. Mirdarikvande ◽  
H. Sadeghi ◽  
A. Godarzi ◽  
M. Alahyari ◽  
H. Shasavari ◽  
...  

Author(s):  
Andang Miatmoko

Purpose: Conjugating cisplatin into hybrid nanoparticles is intended to enhance tumor accumulation due to drug interaction with polymer and prevent premature drug release because of the presence of a lipid layer. Methods: Hybrid nanoparticles composed of polyethylene oxide-b-polymethacrylic acid, egg phosphatidylcholine, and surfactant, i.e. sodium cholate/sodium deoxycholate/Tween 80, were prepared by the injection method. Cisplatin was subsequently loaded by incubating the polymer-drug mixtures at the molar ratio of carboxylate ions of 2:1. Results: The results showed that the addition of surfactants produced particle sizes between 33 and 52 nm. The addition of cisplatin increased the ζ-potential to slightly positive charges with encapsulation efficiencies of 5-18%. An in vivo biodistribution study of mice identified a cisplatin plasma concentration of sodium cholate-modified hybrid nanoparticles ten times higher than cisplatin solution, thus producing high tumor accumulation. Conclusion: Conjugating cisplatin into sodium cholate-modified hybrid nanoparticles improves its accumulation in tumors.


2020 ◽  
Vol 138 (3) ◽  
pp. 49708
Author(s):  
Alina Amirova ◽  
Serafim Rodchenko ◽  
Mikhail Kurlykin ◽  
Andrey Tenkovtsev ◽  
Illia Krasnou ◽  
...  

1999 ◽  
Vol 14 (5) ◽  
pp. 1844-1851 ◽  
Author(s):  
Roger B. Bagwell ◽  
Jürgen Sindel ◽  
Wolfgang Sigmund

The synthesis of barium titanate (BaTiO3) was investigated in water at 90 °C in the presence of polymeric additives. Homopolymers (polyacrylic acid) and block copolymers (polyethylene oxide-block-polymethacrylic acid) were added during synthesis to influence particle morphology and size distribution. The polymers affected the morphological evolution of the forming powder by adsorbing preferentially on specific planes. The polymeric species additionally slowed the formation of barium titanate. The barium concentration also changed the morphology, particle size, and other powder characteristics.


Sign in / Sign up

Export Citation Format

Share Document