The Salivary Inflammatory Biomarkers ( Interleukin-6 , C-Reactive Protein ) in Relation with Caries-Experience among a Group of 12 Year Old Obese Boys

2016 ◽  
Vol 28 (1) ◽  
pp. 138-142
Author(s):  
Ateka R. Aziz ◽  
Ahlam T. Mohammed
Keyword(s):  
Interleukin 6 ◽  
Inflammatory Biomarkers ◽  
Caries Experience ◽  
C Reactive Protein ◽  
Reactive Protein

scholarly journals Inflammatory Biomarkers Do Not Differ Between Persistently Seronegative vs Seropositive People With HIV After Treatment in Early Acute HIV Infection

2020 ◽  
Vol 7 (9) ◽  
Author(s):  
Catherine W Cai ◽  
Suteeraporn Pinyakorn ◽  
Eugène Kroon ◽  
Mark de Souza ◽  
Donn J Colby ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Chronic Inflammation ◽  
Interleukin 6 ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Acute Hiv Infection ◽  
Reactive Protein ◽  
Acute Hiv ◽  
Cluster Of Differentiation ◽  
D Dimer

Abstract Persistent viral activity may cause enduring seropositivity and inflammation in treated people with HIV (PWH). We compared inflammatory biomarkers between early treated PWH who remained seronegative or seroconverted and found similar levels of D-dimer, soluble cluster of differentiation 14, C-reactive protein, and interleukin-6, indicating that seronegativity does not affect chronic inflammation in early treated PWH.

scholarly journals Erythrocyte sedimentation rate, C-reactive protein, and interleukin-6 as inflammatory biomarkers in dogs naturally infected with Ehrlichia canis

2021 ◽  
pp. 2325-2331
Author(s):  
Thanaporn Asawapattanakul ◽  
Tanagorn Pintapagung ◽  
Supawadee Piratae ◽  
Siriluck Juntautsa ◽  
Pawarat Chancharoen
Keyword(s):  
Sedimentation Rate ◽  
Interleukin 6 ◽  
Infected Group ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Healthy Group ◽  
Reactive Protein ◽  
Inflammatory Parameters ◽  
Erythrocyte Sedimentation ◽  
The Mean

Background and Aim: Canine monocytotropic ehrlichiosis (CME), a tick-borne disease, leads to a systemic inflammatory response syndrome; it is thus important to assess the intensity of inflammation in order to treat it appropriately. The current study was designed to evaluate hematological, biochemical, and inflammatory parameters in dogs naturally infected with Ehrlichia canis compared with those in healthy dogs. We also assessed the relationship among several inflammation-related parameters and considered these parameters for use as inflammatory biomarkers of CME. Materials and Methods: Twenty-eight dogs were divided into two groups based on the results of nested polymerase chain reaction for detecting E. canis, comprising a healthy group (n=11) and an infected group (n=17). A blood sample was collected from each dog to evaluate hematological, biochemical, and inflammatory parameters, with the obtained results being statistically compared between the groups. Moreover, the correlations of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and interleukin-6 (IL-6) were investigated in the 28 dogs. Results: In the infected group, the mean levels of red blood cells, hemoglobin, and hematocrit were significantly lower than in the healthy group, while the mean lymphocyte and monocyte counts were higher. The mean levels of ESR and CRP were significantly higher (p<0.05) in the infected group, whereas no significant differences were found in IL-6 levels between the two groups. In the correlation analysis, ESR and CRP levels were highly correlated (p<0.01, r=0.531). Conclusion: Elevated ESR and CRP levels were found in dogs naturally infected with E. canis, which also presented mild to moderate inflammation in this study. Moreover, CRP was significantly correlated with ESR, so ESR and CRP may serve as inflammatory biomarkers for monitoring CME.

scholarly journals Perfil de biomarcadores inflamatórios dos pacientes com pneumonia de um hospital no alto sertão paraibano / Profile of inflammatory biomarkers of patients with pneumonia in a hospital in the upper sertão of Paraíba

2021 ◽  
Vol 15 (57) ◽  
pp. 391-406
Author(s):  
Kamilla Zenóbya Ferreira Nóbrega de Souza ◽  
Elisangela Vilar De Assis ◽  
Marcelo Rodrigues Bacci
Keyword(s):  
Tumor Necrosis Factor ◽  
Kidney Disease ◽  
Interleukin 6 ◽  
Tumor Necrosis ◽  
Inflammatory Biomarkers ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Tnf Α ◽  
Acute Kidney Disease ◽  
Necrosis Factor

Objetivo: Avaliar alterações no perfil de biomarcadores (proteína C reativa, fator de necrose tumoral, interleucina 6 e creatinina) em pacientes com pneumonia, durante o período de internação segundo a sobrevivência ou óbito, relacionando a gravidade do quadro de pneumonia ou indicativo de desenvolvimento de doença renal aguda em pacientes com pneumonia. Método: Foi realizado um estudo prospectivo com 47 pacientes que foram internados com pneumonia, no município de Cajazeiras, PB. Foram realizadas análises laboratoriais para quantificação sérica de creatinina, proteína C reativa, IL-6 e TNF- α. Resultados: Foram analisados segundo o teste de Mann-Whitney e o teste de correlação de Spearman. Foram consideradas diferenças significativas quando p0,05. Observou-se que os níveis de creatinina, proteína C reativa, IL-6 e TNF-α estavam mais elevados no grupo dos pacientes com pneumonia que vieram a óbito.  Os pacientes com pneumonia e doença renal aguda, do grupo que foram a óbito apresentaram maiores níveis de creatinina e IL-6. Para esse o grupo, os níveis de creatinina, TNF-α e IL-6 apresentaram correlação diretamente proporcionais ao escore da escala de CURB-65. Conclusão: Sugere-se que biomarcadores inflamatórios podem ser utilizados no monitoramento de agravo no quadro clínico da doença.Palavras-chave: Creatinina. Fator de Necrose Tumoral Alfa. Interleucina-6. Pneumonia. Proteína C-reativa. Abstract: The aim of this study was to evaluate changes in the profile of biomarkers (C-reactive protein, tumor necrosis factor, interleukin 6 and creatinine) in patients with pneumonia, during the hospitalization period, according to survival or death, relating the severity of pneumonia or indicative of development of acute kidney disease in patients with pneumonia. A prospective study was carried out with 47 patients who were hospitalized with pneumonia in the city of Cajazeiras, Paraíba. Laboratory analyzes were performed to quantify serum creatinine, C-reactive protein, IL-6 and TNF-α. Results were analyzed using the Mann-Whitney test and the Spearman correlation test. Significant differences were considered when p0.05. It was observed that the levels of creatinine, C-reactive protein, IL-6 and TNF-α were higher in the group of patients with pneumonia who died. Patients with pneumonia and acute kidney disease from the group who died had higher levels of creatinine and IL-6. For this group, creatinine, TNF-α and IL-6 levels correlated directly proportional to the CURB-65 scale score. It is suggested that inflammatory biomarkers can be used to monitor the disease's clinical condition. Keywords: Creatinine. Tumor Necrosis Factor Alpha. Interleukin-6. Pneumonia. C-reactive protein.

Changes in inflammatory biomarkers are related to the antidepressant effects of Ayahuasca

2020 ◽  
Vol 34 (10) ◽  
pp. 1125-1133 ◽  
Author(s):  
Nicole Leite Galvão-Coelho ◽  
Ana Cecília de Menezes Galvão ◽  
Raíssa Nóbrega de Almeida ◽  
Fernanda Palhano-Fontes ◽  
Isaac Campos Braga ◽  
...  
Keyword(s):  
Interleukin 6 ◽  
Rating Scale ◽  
Serum Cortisol ◽  
Inflammatory Biomarkers ◽  
Healthy Controls ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Antidepressant Effects ◽  
Pre Treatment

Background: Ayahuasca is a traditional Amazon brew and its potential antidepressant properties have recently been explored in scientific settings. We conducted a double-blind placebo-controlled trial of ayahuasca with treatment-resistant depression patients ( n = 28) and healthy controls ( n = 45). Aims: We are evaluating the blood inflammatory biomarkers: C-reactive protein and interleukin 6, as a potential consequence of ayahuasca intake and their correlation with serum cortisol and brain-derived neurotrophic factor levels. Blood samples were collected at pre-treatment and 48 hours after substance ingestion to assess the concentration of inflammatory biomarkers, together with administration of the Montgomery-Åsberg Depression Rating Scale. Results: At pre-treatment, patients showed higher C-reactive protein levels than healthy controls and a significant negative correlation between C-reactive protein and serum cortisol levels was revealed ( rho = –0.40, n = 14). C-reactive protein in those patients was not correlated with Montgomery-Åsberg Depression Rating Scale scores. We observed a significant reduction of C-reactive protein levels across time in both patients and controls treated with ayahuasca, but not with placebo. Patients treated with ayahuasca showed a significant correlation ( rho = + 0.57) between larger reductions of C-reactive protein and lower depressive symptoms at 48 hours after substance ingestion (Montgomery-Åsberg Depression Rating Scale). No significant result with respect to interleukin 6 and brain-derived neurotrophic factor was found. Furthermore, these biomarkers did not predict the antidepressant response or remission rates observed. Conclusions: These findings enhance the understanding of the biological mechanisms behind the observed antidepressant effects of ayahuasca and encourage further clinical trials in adults with depression.

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