Role of Alpha Lipoic Acid on Metabolic Hepatosteatosis : An Experimental , Biochemical , and Microscopic Study

2015 ◽  
Vol 61 ◽  
pp. 489-498
Author(s):  
Awatief A. Edries ◽  
Ahmed H. El-Rashedy ◽  
Mohamed Wageh
Keyword(s):  
Microscopic Study ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid

scholarly journals The role of oxidative stress and effect of alpha-lipoic acid in reexpansion pulmonary edema – an experimental study

2010 ◽  
Vol 6 ◽  
pp. 848-853 ◽  
Author(s):  
Seyfettin Gumus ◽  
Orhan Yucel ◽  
Mehmet Gamsizkan ◽  
Ayse Eken ◽  
Omer Deniz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Experimental Study ◽  
Pulmonary Edema ◽  
Lipoic Acid ◽  
Alpha Lipoic Acid ◽  
Reexpansion Pulmonary Edema

scholarly journals The Protective Role of Prenatal Alpha Lipoic Acid Supplementation against Pancreatic Oxidative Damage in Offspring of Valproic Acid-Treated Rats: Histological and Molecular Study

Biology ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 239
Author(s):  
Fatma M. Ghoneim ◽  
Hani Alrefai ◽  
Ayman Z. Elsamanoudy ◽  
Salwa M. Abo El-khair ◽  
Hanaa A. Khalaf
Keyword(s):  
Oxidative Stress ◽  
Oxidative Damage ◽  
Lipoic Acid ◽  
Caspase 3 ◽  
Protective Role ◽  
Alpha Lipoic Acid ◽  
Group Iii ◽  
Rat Offspring ◽  
Group I

Background: Sodium valproate (VPA) is an antiepileptic drug (AED) licensed for epilepsy and used during pregnancy in various indications. Alpha-lipoic acid (ALA) is a natural compound inducing endogenous antioxidant production. Our study aimed to investigate the effect of prenatal administration of VPA on the pancreas of rat offspring and assess the potential protective role of ALA co-administration during pregnancy. Methods: Twenty-eight pregnant female albino rats were divided into four groups: group I (negative control), group II (positive control, ALA treated), group III (VPA-treated), and group IV (VPA-ALA-treated). The pancreases of the rat offspring were removed at the fourth week postpartum and prepared for histological, immune-histochemical, morphometric, molecular, and oxidative stress marker studies. Results: In group III, there were pyknotic nuclei, vacuolated cytoplasm with ballooning of acinar, α, and β cells of the pancreas. Ultrastructural degeneration of cytoplasmic organelles was detected. Additionally, there was a significant increase in oxidative stress, a decrease in insulin-positive cell percentage, and an increase in glucagon positive cells in comparison to control groups. Moreover, VPA increased the gene expression of an apoptotic marker, caspase-3, with a decrease in anti-apoptotic Bcl2 and nuclear factor erythroid 2-related factor 2 (Nrf2) transcriptional factor. Conversely, ALA improved oxidative stress and apoptosis in group VI, and a consequent improvement of the histological and ultrastructure picture was detected. Conclusion: ALA co-administration with VPA significantly improved the oxidative stress condition, histological and morphometric picture of the pancreas, and restored normal expression of related genes, including Nrf2, caspase-3, and Bcl-2. Administration of α-lipoic acid has a protective effect against VPA-induced pancreatic oxidative damage via its cytoprotective antioxidant effect.

scholarly journals PSXIV-19 Effect of alpha-lipoic acid on productive parameters and ruminal VFA profile in sheep

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 437-438
Author(s):  
Carolina Robles ◽  
Laura Gonzáles Davalos ◽  
Ofelia Mora ◽  
Yesmin Hermanadez ◽  
Armando Shimada ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Lipoic Acid ◽  
Insulin Receptors ◽  
Daily Weight Gain ◽  
Oxidative Decarboxylation ◽  
Alpha Lipoic Acid ◽  
Randomized Design ◽  
Keto Acids ◽  
Mechanism Research

Abstract Alpha lipoic acid (LA) is a potent nutritional antioxidant. It is a derivate of octanoic acid containing a cyclic disulfide bond. An LA complex with lysine-lipoamide, functions as a co-factor in the mitochondrial dehydrogenase that catalyzes the oxidative decarboxylation of α-keto acids. In this reaction, LA is reduced to dihydrolipoic acid (DHLA), which interacts with reactive oxygen species, and LA can also inactivate free radicals. Another important role of DHLA is in signal transduction by activating insulin receptors, which causes glucose transporters translocation from cytoplasm to the cell surface. Due to its potential antioxidant effect at ruminal level, the aim of this study was to evaluate the effect of fed LA on productive parameters, ruminal fatty volatile fatty acid (VFA) concentration and blood glucose of sheep. Sixty-four, two-months-old, crossbred lambs were penned in groups of four, divided into four treatments: 0, 40, 80, and 120 ppm LA in diet. During 84 days, every 28 days on two consecutive days, animals were weighed (to determine average daily weight gain, DWG), blood and ruminal fluid were taken for glucose and VFA quantification, respectively. All variables were analyzed in a completely randomized design. DWG was statistically higher in those animals receiving 80 ppm (250 g) as compared to the rest (200, 188, 180 g for 120, 40, 0 ppm, respectively) (P < 0.0001). No differences in blood glucose or ruminal VFA were found (P > 0.1). LA could improve the productive performance of sheep; however, it would be necessary to study the role of LA and its effects on the ruminal microbiome and its action mechanism. Research support by Project PAPIIT-UNAM IN211518

scholarly journals Role of Alpha Lipoic Acid in Ameliorating the Histological Alterations of Pituitary-Testicular Axis –induced by Hydrogen Peroxide in Rats

2020 ◽  
Vol 13 (2) ◽  
pp. 125-136
Author(s):  
Mohammad Alwan ◽  
Baraa Al-Okialy
Keyword(s):  
Hydrogen Peroxide ◽  
Lipoic Acid ◽  
Tap Water ◽  
Degenerative Changes ◽  
Male Rats ◽  
Seminiferous Tubules ◽  
Alpha Lipoic Acid ◽  
Water Group ◽  
Testicular Weight

The present study was aimed to investigate the role of alpha-lipoic acid ( ALA) as an antioxidant against in ameliorating histological disorders of pituitary- testicular axis- induced by hydrogen peroxide (H2O2) in adult Wistar rats. Forty adult male rats were randomly divided into four equal groups (10 rats /group) and were handled daily as follows for 56 days: Control group ( C) were intubated distilled water and received ordinary tap water; group T1 were intubated 60mg/kg B.W of ALA and received ordinary tap water; group T2 were administered H2O2 in tap water at a concentration of 0.05%, while group T3 were intubated 60mg/kg B.W of ALA and received ordinary tap water containing 0.05% H2O2. At the end of the experiment, body weights were recorded, then pituitary and testes were excised for histopathological study and testicular weight was recorded too. Rats administered H2O2 showed a significant decrease in testes weight to body weight ratio accompanied with major histopathological changes of the testes in comparison with other groups including; a significant decrease in the diameter of seminiferous tubules, high of germinal epithelial cell and degenerative changes with incomplete spermatogenesis. Besides, a significant decrease in the number of Leydig's cells in comparison with other experimental groups. Furthermore, pituitary gland of group T2 manifested a severe histological alteration in architecture characterized by atrophy with marked necrotic and degenerative changes. Whereas, rats administered ALA (group T3) shows an improvement of histological changes of pituitary and testicular tissues induced by hydrogen peroxide. In conclusion, the results indicated that alpha-lipoic acid mitigated pituitary-testicular dysfunctions induced by H2O2 through its antioxidant effects via scavenging free radicals.

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