Molecular Localization of Envelope Gene Sequence of Human Mammary Tumor Virus in Malignant Endometrial and Cervical Tissues from Iraqi Patients in Baghdad

2015 ◽  
Vol 10 (2) ◽  
pp. 53-58
Author(s):  
Saad H. M. Ali ◽  
Basim S. Ahmed ◽  
Sura D. Dawood
Keyword(s):  
Mammary Tumor ◽  
Gene Sequence ◽  
Envelope Gene ◽  
Mammary Tumor Virus ◽  
Tumor Virus ◽  
Human Mammary Tumor Virus

scholarly journals Human Mammary Tumor Virus (HMTV) sequences in human milk

2014 ◽  
Vol 9 (1) ◽  
pp. 20 ◽  
Author(s):  
Teiko Nartey ◽  
Heberth Moran ◽  
Tania Marin ◽  
Kathleen F Arcaro ◽  
Douglas L Anderton ◽  
...  
Keyword(s):  
Human Milk ◽  
Mammary Tumor ◽  
Mammary Tumor Virus ◽  
Tumor Virus ◽  
Human Mammary Tumor Virus

Detection of Retroviral Superantigen and Products of the Envelope Gene from Endogenous Mouse Mammary Tumor Virus in B Cells from BALB/c Mice

1995 ◽  
Vol 163 (2) ◽  
pp. 191-197 ◽  
Author(s):  
Mayra Lopez-Cepero ◽  
Yang Wang ◽  
Iafa Keydar ◽  
Carolyn Brandt-Carlson ◽  
Janet S. Butel ◽  
...  
Keyword(s):  
B Cells ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Envelope Gene ◽  
Mammary Tumor Virus ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

Abstract P4-06-01: Human mammary tumor virus, HMTV, is an MMTV-adapted human pathogen

2016 ◽  
Author(s):  
JF Holland ◽  
S Jaffer ◽  
S Melana ◽  
T Nartey ◽  
S Gnjatic ◽  
...  
Keyword(s):  
Mammary Tumor ◽  
Human Pathogen ◽  
Mammary Tumor Virus ◽  
Tumor Virus ◽  
Human Mammary Tumor Virus

scholarly journals Human mammary tumor virus in inflammatory breast cancer

Cancer ◽  
2010 ◽  
Vol 116 (S11) ◽  
pp. 2741-2744 ◽  
Author(s):  
Beatriz G.-T. Pogo ◽  
James F. Holland ◽  
Paul H. Levine
Keyword(s):  
Breast Cancer ◽  
Inflammatory Breast Cancer ◽  
Mammary Tumor ◽  
Mammary Tumor Virus ◽  
Tumor Virus ◽  
Human Mammary Tumor Virus

scholarly journals Mouse Mammary Tumor Virus Encodes a Self-Regulatory RNA Export Protein and Is a Complex Retrovirus

2005 ◽  
Vol 79 (23) ◽  
pp. 14737-14747 ◽  
Author(s):  
Jennifer A. Mertz ◽  
Melissa S. Simper ◽  
Mary M. Lozano ◽  
Shelley M. Payne ◽  
Jaquelin P. Dudley
Keyword(s):  
Mammary Tumor ◽  
Nuclear Export ◽  
Mouse Mammary Tumor Virus ◽  
Protein Product ◽  
Envelope Gene ◽  
Mammary Tumor Virus ◽  
Gag Protein ◽  
Mouse Mammary Tumor ◽  
Tumor Virus ◽  
Rna Export

ABSTRACT Mouse mammary tumor virus (MMTV) has been classified as a simple retrovirus with two accessory genes, dut and sag. Cloned MMTV proviruses carrying a trimethoprim (trim) cassette in the envelope gene were defective for Gag protein production and the nuclear export of unspliced gag-pol RNA. Complementation experiments indicated that a trans-acting product was responsible for the Gag defect of such mutants. Analysis of MMTV-infected cells revealed the presence of a novel, doubly spliced RNA that encodes a putative product of 301 amino acids. Overexpression of cDNA from this RNA increased Gag levels from env mutant proviruses or reporter gene expression from unspliced mRNAs and allowed detection of a 33-kDa protein product, which has been named regulator of export of MMTV mRNA, or Rem. The Rem N terminus has motifs similar to the Rev-like export proteins of complex retroviruses, and mutation of the nuclear localization signal (NLS) abolished RNA export and detection within the nucleus. The Rem C terminus has few identifiable features, but removal of this domain increased Rem-mediated export, suggesting an autoregulatory function. A reporter vector developed from the 3′ end of the MMTV provirus was Rem responsive and required both the presence of the MMTV env-U3 junction and a functional Crm1 pathway. The identification of a third accessory protein from a doubly spliced transcript suggests that MMTV is the first murine complex retrovirus to be documented. Manipulation of the MMTV genome may provide mouse models for human retroviral diseases, such as AIDS.

scholarly journals The mouse mammary tumor virus envelope gene product is required for superantigen presentation to T cells.

1994 ◽  
Vol 179 (2) ◽  
pp. 439-446 ◽  
Author(s):  
T V Golovkina ◽  
A Chervonsky ◽  
J A Prescott ◽  
C A Janeway ◽  
S R Ross
Keyword(s):  
T Cells ◽  
T Cell ◽  
Gene Product ◽  
Mammary Tumor ◽  
Mouse Mammary Tumor Virus ◽  
Envelope Gene ◽  
Mammary Tumor Virus ◽  
Cell Surface Glycoprotein ◽  
Mouse Mammary Tumor ◽  
Tumor Virus

Transgenic mice expressing either the mouse mammary tumor virus (MMTV) superantigen gene (sag) alone or in combination with the viral envelope genes (env) (LEL), or all of the viral genes (gag, pol, env, and sag) (HYB PRO), deleted V beta 14+ T cells from their immune repertoire. However, only LEL or HYB PRO transgenic antigen-presenting cells were capable of stimulating a proliferative response from nontransgenic primary T cells or interleukin 2 production from a V beta 15-bearing T cell hybridoma. These T cell responses could be inhibited by a monospecific antibody directed against the MMTV gp52 cell surface glycoprotein. These results indicate that the MMTV gp52 gene product participates in the presentation of superantigen to T cells, resulting in their stimulation, a requisite step in the MMTV infection pathway. Thus, gp52 could play a role in the transfer of virus between different subsets of lymphocytes.

scholarly journals Low prevalence of human mammary tumor virus (HMTV) in breast cancer patients from Myanmar

2017 ◽  
Vol 12 (1) ◽  
Author(s):  
Thar Htet San ◽  
Masayoshi Fujisawa ◽  
Soichiro Fushimi ◽  
Teizo Yoshimura ◽  
Toshiaki Ohara ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Mammary Tumor ◽  
Breast Cancer Patients ◽  
Mammary Tumor Virus ◽  
Tumor Virus ◽  
Low Prevalence ◽  
Human Mammary Tumor Virus

Human Mammary Tumor Virus (HMTV) in Endometrial Carcinoma

2013 ◽  
Vol 23 (8) ◽  
pp. 1423-1428 ◽  
Author(s):  
Liane Deligdisch ◽  
Tania Marin ◽  
Anna T. Lee ◽  
Polly Etkind ◽  
James F. Holland ◽  
...  
Keyword(s):  
Endometrial Carcinoma ◽  
Mammary Tumor ◽  
Mammary Tumor Virus ◽  
Tumor Virus ◽  
Human Mammary Tumor Virus
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