Immunohistochemical Study of IL-17 Expression in Prostate Tissue of a Prostate Cancer Patients

2015 ◽  
Vol 10 (2) ◽  
pp. 37-41
Author(s):  
Hassan H. Zrage ◽  
Zainab F. Ashoor ◽  
Wasan A. Bakir
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Immunohistochemical Study ◽  
Prostate Tissue

scholarly journals 2128 HIGH TESTOSTERONE LEVELS IN PROSTATE TISSUE OBTAINED BY NEEDLE BIOPSY CORRELATE WITH POOR PROGNOSIS FACTORS IN PROSTATE CANCER PATIENTS

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Yasuhide Miyoshi ◽  
Susumu Umemoto ◽  
Uemura Hiroji ◽  
Seijiro Honma ◽  
Yasuhiro Shibata ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Needle Biopsy ◽  
Poor Prognosis ◽  
Prostate Tissue ◽  
Prognosis Factors ◽  
Testosterone Levels

scholarly journals High testosterone levels in prostate tissue obtained by needle biopsy correlate with poor-prognosis factors in prostate cancer patients

BMC Cancer ◽  
2014 ◽  
Vol 14 (1) ◽  
Author(s):  
Yasuhide Miyoshi ◽  
Hiroji Uemura ◽  
Susumu Umemoto ◽  
Kentaro Sakamaki ◽  
Satoshi Morita ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Needle Biopsy ◽  
Poor Prognosis ◽  
Prostate Tissue ◽  
Prognosis Factors ◽  
Testosterone Levels

scholarly journals Identification and Validation of Potential New Biomarkers for Prostate Cancer Diagnosis and Prognosis Using 2D-DIGE and MS

2015 ◽  
Vol 2015 ◽  
pp. 1-23 ◽  
Author(s):  
Cordelia Geisler ◽  
Nadine T. Gaisa ◽  
David Pfister ◽  
Susanne Fuessel ◽  
Glen Kristiansen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Western Blot ◽  
Cancer Patients ◽  
Cancer Diagnosis ◽  
Prostate Tissue ◽  
Biochemical Relapse ◽  
Prostate Cancer Diagnosis ◽  
2D Dige ◽  
Diagnosis And Prognosis ◽  
New Biomarkers

This study was designed to identify and validate potential new biomarkers for prostate cancer and to distinguish patients with and without biochemical relapse. Prostate tissue samples analyzed by 2D-DIGE (two-dimensional difference in gel electrophoresis) and mass spectrometry (MS) revealed downregulation of secernin-1 (P< 0.044) in prostate cancer, while vinculin showed significant upregulation (P< 0.001). Secernin-1 overexpression in prostate tissue was validated using Western blot and immunohistochemistry while vinculin expression was validated using immunohistochemistry. These findings indicate that secernin-1 and vinculin are potential new tissue biomarkers for prostate cancer diagnosis and prognosis, respectively. For validation, protein levels in urine were also examined by Western blot analysis. Urinary vinculin levels in prostate cancer patients were significantly higher than in urine from nontumor patients (P= 0.006). Using multiple reaction monitoring-MS (MRM-MS) analysis, prostatic acid phosphatase (PAP) showed significant higher levels in the urine of prostate cancer patients compared to controls (P= 0.012), while galectin-3 showed significant lower levels in the urine of prostate cancer patients with biochemical relapse, compared to those without relapse (P= 0.017). Three proteins were successfully differentiated between patients with and without prostate cancer and patients with and without relapse by using MRM. Thus, this technique shows promise for implementation as a noninvasive clinical diagnostic technique.

Low stroma androgen receptor level in normal and tumor prostate tissue is related to poor outcome in prostate cancer patients

The Prostate ◽  
2009 ◽  
Vol 69 (8) ◽  
pp. 799-809 ◽  
Author(s):  
Pernilla Wikström ◽  
Josip Marusic ◽  
Pär Stattin ◽  
Anders Bergh
Keyword(s):  
Prostate Cancer ◽  
Androgen Receptor ◽  
Cancer Patients ◽  
Prostate Tissue ◽  
Receptor Level ◽  
Poor Outcome

Immunohistochemical Analysis of Prostein Expression in Archived Prostatic Core Biopsies from Prostate Cancer Patients in Western Kenya

2021 ◽  
Author(s):  
Omondi Swaya Tyrus ◽  
Dedan Opondo ◽  
David O. Atandi ◽  
Benard Guyah ◽  
Ng’wena Gideon Magak
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Core Biopsy ◽  
Staining Pattern ◽  
Immunohistochemical Analysis ◽  
Composite Score ◽  
Prostate Tissue ◽  
Diagnostic Utility ◽  
Western Kenya ◽  
Low Sensitivity

Abstract Background Prostate cancer is the leading cause of cancer-associated mortality in men. Most of the current biomarkers for detection of the disease have low sensitivity and specificity. Prostein is a newly reported prostate cancer biomarkers whose diagnostic utility can help in early detection of the disease. Nonetheless, previous studies have utilized limited number of samples to evaluate its immunohistochemistry (IHC) and reports on the African population are not available. The current study aimed to determine the prostein expression in archived prostatic core biopsies from prostate cancer patients in Western Kenya. Materials and Methods This was a retrospective study conducted on malignant and benign prostatic tissue core biopsies of 106 patients who underwent prostate core biopsy at Jaramogi Oginga Odinga Teaching and Referral Hospital and division of urology at Synergy Clinics, Kisumu between January 2018 to May 2021. Immunohistochemical technique was performed on each of the 106 samples and on the following non-prostatic male control biopsies; Testis, Penis, Liver and Esophagus. Cellular location of prostein staining was evaluated at X40, X100 and X400 magnification using a light microscope and was classified as cytoplasmic or nucleocytoplasmic. Intensity of prostein expression was assessed for each core biopsy at similar magnification and graded according the immunohistochemistry composite score. Results The biopsies had been obtained from men whose mean (SE) age was 72.00±0.93 years. 95.3% (101) of the biopsies were malignant and 4.7% (5) were benign. Four non-prostatic male tissues were included. 97% of malignant and all the benign prostate tissue stained positive for prostein whereas the four non-prostatic male tissues were negative. Staining intensities were weak (24.5%), Moderate (17.0%), strong (55.7%) and non-stained (2.8%). The staining was highly immunolocalized within the cytoplasm (95.1% cases) as compared to nucleocytoplasmic (2.0% cases). The mean immunoreactivity composite score was 1.91±0.96 (0.0-3.14). Strongly stained sections had a punctate plasma membrane staining pattern clustered within the cytoplasm in a perinuclear location whereas the weakly stained sections had faint and punctate coarse brown cytoplasmic granular appearing. Conclusion Prostein is exclusively expressed in benign and malignant prostate tissue with a higher cytoplasmic granular staining pattern in the present population. These findings suggest that prostein diagnostic utility is applicable in the current study population and routine IHC diagnosis of prostate cancer may be recommended.

390: Durable Cancer Control in High Risk Prostate Cancer Patients Treated with Radical Prostatectomy

2007 ◽  
Vol 177 (4S) ◽  
pp. 130-130
Author(s):  
Markus Graefen ◽  
Jochen Walz ◽  
Andrea Gallina ◽  
Felix K.-H. Chun ◽  
Alwyn M. Reuther ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
High Risk ◽  
Radical Prostatectomy ◽  
Cancer Patients ◽  
Cancer Control ◽  
High Risk Prostate Cancer ◽  
Risk Prostate Cancer

598: Increased Risk of Newly Diagnosed Comorbidities in Prostate Cancer Patients Treated with Androgen Deprivation Therapy

2007 ◽  
Vol 177 (4S) ◽  
pp. 200-200 ◽  
Author(s):  
Andrea Gallina ◽  
Pierre I. Karakiewicz ◽  
Jochen Walz ◽  
Claudio Jeldres ◽  
Quoc-Dien Trinh ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Patients ◽  
Androgen Deprivation Therapy ◽  
Androgen Deprivation ◽  
Newly Diagnosed ◽  
Increased Risk
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