Levels of Interleukin 17 , Interleukin 23 and Interleukin 27 in Rheumatoid Arthritis and Osteoarthritis in Egyptian Patients

2013 ◽  
Vol 42 (4) ◽  
pp. 629-642 ◽  
Author(s):  
Ashraf Ismail Mustafa Khalifa ◽  
Hanan Abd Elmawgood Atia ◽  
Sara Saad
Keyword(s):  
Rheumatoid Arthritis ◽  
Interleukin 17 ◽  
Interleukin 27 ◽  
Egyptian Patients ◽  
Interleukin 23

scholarly journals Effect of Narrow Band Ultraviolet B Therapy versus Methotrexate on Serum Levels of Interleukin-17 and Interleukin-23 in Egyptian Patients with Severe Psoriasis

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Tarek Mahmoud Elghandour ◽  
Sahar El Sayed Youssef ◽  
Dalia Gamal Aly ◽  
Mohamed Said Abd Elhameed ◽  
Mehrevan Mostafa Abdel Moneim
Keyword(s):  
Narrow Band ◽  
Serum Levels ◽  
Severe Psoriasis ◽  
Ultraviolet B ◽  
Interleukin 17 ◽  
Egyptian Patients ◽  
Interleukin 23

scholarly journals Proteomic characterisations of ulcerative colitis endoscopic biopsies associate with clinically relevant histological measurements of disease severity

2021 ◽  
pp. jclinpath-2021-207718
Author(s):  
Aaron M Gruver ◽  
Matt D Westfall ◽  
Bradley L Ackermann ◽  
Salisha Hill ◽  
Ryan D Morrison ◽  
...  
Keyword(s):  
Ulcerative Colitis ◽  
Accuracy Assessment ◽  
Interleukin 2 ◽  
Proteome Analysis ◽  
Scoring Systems ◽  
Cell Junction ◽  
Interleukin 17 ◽  
Gamma Chain ◽  
Novel Approach ◽  
Interleukin 23

Aims and methodsAccurate protein measurements using formalin-fixed biopsies are needed to improve disease characterisation. This feasibility study used targeted and global mass spectrometry (MS) to interrogate a spectrum of disease severities using 19 ulcerative colitis (UC) biopsies.ResultsTargeted assays for CD8, CD19, CD132 (interleukin-2 receptor subunit gamma/common cytokine receptor gamma chain), FOXP3 (forkhead box P3) and IL17RA (interleukin 17 receptor A) were successful; however, assays for IL17A (interleukin 17A), IL23 (p19) (interleukin 23, alpha subunit p19) and IL23R (interleukin 23 receptor) did not permit target detection. Global proteome analysis (4200 total proteins) was performed to identify pathways associated with UC progression. Positive correlation was observed between histological scores indicating active colitis and neutrophil-related measurements (R2=0.42–0.72); inverse relationships were detected with cell junction targets (R2=0.49–0.71) and β-catenin (R2=0.51–0.55) attributed to crypt disruption. An exploratory accuracy assessment with Geboes Score and Robarts Histopathology Index cut-offs produced sensitivities/specificities of 72.7%/75.0% and 100.0%/81.8%, respectively.ConclusionsPathologist-guided MS assessments provide a complementary approach to histological scoring systems. Additional studies are indicated to verify the utility of this novel approach.

Association of XRCC1 and OGG1 DNA repair gene polymorphisms with rheumatoid arthritis in Egyptian patients

Gene ◽  
2016 ◽  
Vol 578 (1) ◽  
pp. 112-116 ◽  
Author(s):  
Randa H. Mohamed ◽  
Amal S. El-Shal ◽  
Eman E. El-Shahawy ◽  
Sahar M. Abdel Galil
Keyword(s):  
Rheumatoid Arthritis ◽  
Dna Repair ◽  
Gene Polymorphisms ◽  
Repair Gene ◽  
Dna Repair Gene ◽  
Egyptian Patients

Interleukin-1 β gene polymorphisms in Egyptian patients with rheumatoid arthritis

2013 ◽  
Vol 23 (3) ◽  
pp. 689-694 ◽  
Author(s):  
Rania Kamal Darwish ◽  
Dalia Ibrahim Ramadan ◽  
Abeer Mohamed Mohy ◽  
Hala Ahmed Raafat ◽  
Hazem El-Sayed Abou Youssef ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Gene Polymorphisms ◽  
Interleukin 1 ◽  
Egyptian Patients
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