Postoperative Wound Sepsis Following Major Lower Extremity Amputations in Patients with Diabetes : Case - Control Study = إنتان جروح ما بعد عمليات البتر الكبرى في الطرف السفلي عند مرضى السكري

2014 ◽  
Vol 50 (3) ◽  
pp. 129-136
Author(s):  
Omer A. A. Abdel Sadiq ◽  
Mohamed ElMakki Ahmed ◽  
Aamir A. Hamza
Keyword(s):  
Lower Extremity ◽  
Case Control Study ◽  
Case Control ◽  
Wound Sepsis ◽  
Postoperative Wound ◽  
Diabetes Case ◽  
Patients With Diabetes ◽  
Control Study

scholarly journals Timing of access to secondary healthcare services and lower extremity amputations in patients with diabetes: a case–control study

2015 ◽  
Vol 3 (1) ◽  
pp. e000069 ◽  
Author(s):  
Claire M Buckley ◽  
Fauzi Ali ◽  
Graham A Roberts ◽  
Patricia M Kearney ◽  
Ivan J Perry ◽  
...  
Keyword(s):  
Lower Extremity ◽  
Case Control Study ◽  
Healthcare Services ◽  
Case Control ◽  
Patients With Diabetes ◽  
Control Study

scholarly journals Plasma acylcarnitines and risk of lower-extremity functional impairment in older adults: a nested case–control study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Francisco Félix Caballero ◽  
Ellen A. Struijk ◽  
Alberto Lana ◽  
Antonio Buño ◽  
Fernando Rodríguez-Artalejo ◽  
...  
Keyword(s):  
Older Adults ◽  
Confidence Interval ◽  
Lower Extremity ◽  
Functional Impairment ◽  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
Community Dwelling ◽  
Control Study ◽  
Long Chain

AbstractElevated concentrations of acylcarnitines have been associated with higher risk of obesity, type 2 diabetes and cardiovascular disease. The aim of the present study was to assess the association between L-carnitine and acylcarnitine profiles, and 2-year risk of incident lower-extremity functional impairment (LEFI). This case–control study is nested in the Seniors-ENRICA cohort of community-dwelling older adults, which included 43 incident cases of LEFI and 86 age- and sex- matched controls. LEFI was assessed with the Short Physical Performance Battery. Plasma L-carnitine and 28 acylcarnitine species were measured. After adjusting for potential confounders, medium-chain acylcarnitines levels were associated with 2-year incidence of LEFI [odds ratio per 1-SD increase: 1.69; 95% confidence interval: 1.08, 2.64; p = 0.02]. Similar results were observed for long-chain acylcarnitines [odds ratio per 1-SD increase: 1.70; 95% confidence interval: 1.03, 2.80; p = 0.04]. Stratified analyses showed a stronger association between medium- and long-chain acylcarnitines and incidence of LEFI among those with body mass index and energy intake below the median value. In conclusion, higher plasma concentrations of medium- and long-chain acylcarnitines were associated with higher risk of LEFI. Given the role of these molecules on mitochondrial transport of fatty acids, our results suggest that bioenergetics dysbalance contributes to LEFI.

Evaluating the efficacy of topical vancomycin powder in the treatment of open lower extremity fractures

Trauma ◽  
2020 ◽  
pp. 146040862097814
Author(s):  
Justin Vaida ◽  
Alexander DB Conti ◽  
Justin J Ray ◽  
Daniel A Bravin ◽  
Michelle A Bramer
Keyword(s):  
Lower Extremity ◽  
Case Control Study ◽  
Smoking Status ◽  
Case Control ◽  
Wound Complications ◽  
Control Group ◽  
Retrospective Case ◽  
Vancomycin Powder ◽  
Control Study

Introduction Optimal management of lower extremity fractures includes early antibiotics administration, thorough irrigation and debridement, consideration of soft tissue injury, and definitive skeletal management. The purpose of this study was to evaluate the efficacy of topical vancomycin powder in the treatment of open lower extremity fractures. Methods This was a retrospective case control study in which open lower extremity fractures at our institution were reviewed for development of infection (including species and sensitivity if present) and the development of unanticipated wound complications requiring intervention. Patients from 2010-2015 were treated with standard of care consistent with evidence-based literature (IV antibiotics with external fixator, intramedullary nail, etc.). Patients from 2016–18 were additionally treated with vancomycin powder applied directly to the wound before closure. All patients were monitored per the treating surgeon’s standard follow-up protocol and had follow-up of at least two months. Results This retrospective case control study comprised 434 patients. The historical control group (n = 388 patients) and treatment group (n = 46 patients) were similar for age, sex, BMI (body mass index), diabetes, smoking status, and Injury Severity Score (ISS). There were 36 infections (9.28%) in the control group compared to four infections (8.70%) in the vancomycin powder group (p = 0.901). No significant difference was seen after adjusting for age, sex, BMI, diabetes, smoking status, and ISS. The vancomycin powder group experienced significantly more wound complications (15.2%) compared to the control group (6.4%; p = 0.039), which remained significant when adjusting for multiple covariates. Conclusions Topical vancomycin powder did not reduce the infection rate when applied in the surgical site of open lower extremity fractures. Instead, the addition of topical vancomycin powder resulted in significantly more wound complications in patients with open lower extremity fractures.

Peripapillary Retinal Nerve Fiber Layer Changes in Patients with Diabetes Mellitus: A Case-control Study

2020 ◽  
Vol 35 (4) ◽  
pp. 257-260
Author(s):  
Irini Chatziralli ◽  
Aristotelis Karamaounas ◽  
Eleni Dimitriou ◽  
Dimitrios Kazantzis ◽  
George Theodossiadis ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Case Control Study ◽  
Case Control ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Patients With Diabetes ◽  
Control Study ◽  
Retinal Nerve Fiber

scholarly journals Risk of Community-Acquired Pneumococcal Bacteremia in Patients With Diabetes: A population-based case-control study

Diabetes Care ◽  
2004 ◽  
Vol 27 (5) ◽  
pp. 1143-1147 ◽  
Author(s):  
R. Wernich Thomsen ◽  
H. Holmager Hundborg ◽  
H.-H. Lervang ◽  
S. Paaske Johnsen ◽  
H. C. Schonheyder ◽  
...  
Keyword(s):  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Pneumococcal Bacteremia ◽  
Patients With Diabetes ◽  
Control Study

scholarly journals Use of Thiazolidinediones and the Risk of Colorectal Cancer in Patients With Diabetes: A nationwide, population-based, case-control study

Diabetes Care ◽  
2012 ◽  
Vol 36 (2) ◽  
pp. 369-375 ◽  
Author(s):  
S.-W. Chen ◽  
Y.-T. Tsan ◽  
J.-D. Chen ◽  
H.-I. Hsieh ◽  
C.-H. Lee ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Patients With Diabetes ◽  
Control Study
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