Influence of Concentration of Modified Maize Starch on Compaction Characteristics and Mechanical Properties of Paracetamol Tablet Formulations

2013 ◽  
Vol 21 (3) ◽  
pp. 125-131 ◽  
Author(s):  
Musibau A. Mustapha ◽  
Cecilia I. Igwilo ◽  
Boladale O. Silva
Keyword(s):  
Mechanical Properties ◽  
Maize Starch ◽  
Compaction Characteristics ◽  
Tablet Formulations ◽  
Paracetamol Tablet

scholarly journals Potential and Comparative Tablet Disintegrant Properties of Pectin Obtained from Five Okra Genotypes in Ghana

Scientifica ◽  
2021 ◽  
Vol 2021 ◽  
pp. 1-11
Author(s):  
Frederick William Akuffo Owusu ◽  
Mariam El Boakye-Gyasi ◽  
Jacob Kwaku Agbenorhevi ◽  
Marcel Tunkumgnen Bayor ◽  
Kwabena Ofori-Kwakye
Keyword(s):  
Immediate Release ◽  
Dissolution Profile ◽  
Maize Starch ◽  
Dissolution Tests ◽  
The World ◽  
Weight Test ◽  
Pharmaceutical Industries ◽  
Tablet Formulations ◽  
Low Levels ◽  
Paracetamol Tablet

Okra pectin has been studied as a potential excipient in tablet formulations for pharmaceutical industries. Okra is widely grown and available in Ghana and other parts of the world. The prospective use of pectin from okra genotypes grown in Ghana as tablet disintegrants has not been reported. This study aims to determine the potential and comparative disintegrating properties of pectin from five okra genotypes (Abelmoschus esculentus L.) in Ghana using uncoated immediate release paracetamol tablet formulations. The yield of the pectin from the various genotypes ranged between 6.12 and 18.84% w/w. The extracted pectins had pH ranging from slightly acidic to almost neutral (6.39–6.92). Pectin from the various genotypes exhibited good swelling indexes (˃200%), varying solubility in different solvents, and low moisture content (˂20%). Elemental analysis of the extracted pectin from the various genotypes revealed very low levels of toxic metals and micronutrients. Pectin from the various genotypes was evaluated as disintegrants within concentrations of 5–10% w/w (F1–F18). Their disintegrating properties were compared to that of maize starch BP. All the formulated batches of uncoated immediate release paracetamol tablets (F1–F18) passed the following: uniformity of weight test, uniformity of dimensions, hardness, friability (˂1%), and drug content (95–105%). Significant differences ( p ≤ 0.05 ) were observed between the hardness of the maize starch tablets and tablets formulated from pectin of the various genotypes. Pectin from all genotypes other than PC5 exhibited good disintegrating properties (DT ˂ 15 min) and subsequently passed the dissolution profile test (≥70% release in 45 minutes). Tablets formulated with PC5 as disintegrants at all concentrations (5% w/w (F5), 7.5% w/w (F11), and 10% w/w (F17)) failed the disintegration and dissolution tests. Ultimately, pectins extracted from PC1, PC2, PC3, and PC4 can be commercially exploited as disintegrants in immediate release tablets.

scholarly journals Evaluation of the Disintegrant Properties of Native Starches of Five New Cassava Varieties in Paracetamol Tablet Formulations

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Frank Kumah Adjei ◽  
Yaa Asantewaa Osei ◽  
Noble Kuntworbe ◽  
Kwabena Ofori-Kwakye
Keyword(s):  
Metal Ion ◽  
Toxic Metal ◽  
Immediate Release ◽  
Maize Starch ◽  
Flow Properties ◽  
Efficiency Ratio ◽  
Swelling Capacity ◽  
Tablet Formulations ◽  
Paracetamol Tablet ◽  
Cassava Varieties

The disintegrant potential of native starches of five new cassava (Manihot esculenta Crantz.) varieties developed by the Crops Research Institute of Ghana (CRIG) was studied in paracetamol tablet formulations. The yield of the starches ranged from 8.0 to 26.7%. The starches were basic (pH: 8.1–9.9), with satisfactory moisture content (≤15%), swelling capacity (≥20%), ash values (<1%), flow properties, and negligible toxic metal ion content, and compatible with the drug. The tensile strength (Ts), crushing strength (Cs), and friability (Ft) of tablets containing 5–10% w/w of the cassava starches were similar (p>0.05) to those containing maize starch BP. The disintegration times of the tablets decreased with increase in concentration of the cassava starches. The tablets passed the disintegration test (DT ≤ 15 min) and exhibited faster disintegration times (p>0.05) than those containing maize starch BP. The disintegration efficiency ratio (DER) and the disintegration parameter DERc of the tablets showed that cassava starches V20, V40, and V50 had better disintegrant activity than maize starch BP. The tablets passed the dissolution test for immediate release tablets (≥70% release in 45 min) with dissolution rates similar to those containing maize starch BP.

scholarly journals Compressional, mechanical and release properties of a novel gum in paracetamol tablet formulations

2014 ◽  
Vol 27 (3) ◽  
pp. 187-194 ◽  
Author(s):  
Musiliu O. Adedokun ◽  
John O. Ayorinde ◽  
Michael A. Odeniyi
Keyword(s):  
Mechanical Properties ◽  
Drug Release ◽  
Binding Properties ◽  
Crushing Strength ◽  
Density Measurements ◽  
Pharmaceutical Tablets ◽  
Compression Properties ◽  
Tablet Formulations ◽  
Binder Concentration ◽  
Paracetamol Tablet

ABSTRACT The binding properties of Eucalyptus gum obtained from the incised trunk of Eucalyptus tereticornis, were evaluated in paracetamol tablet formulations, in comparison with that of Gelatin B.P. In so doing, the compression properties were analyzed using density measurements and the compression equations of Heckel, Kawakita and Gurham. In our work, the mechanical properties of the tablets were assessed using the crushing strength and friability of the tablets, while the drug release properties of the tablets were assessed using disintegration and dissolution times. The results of the study reveal that tablet formulations incorporating Eucalyptus gum as binder, exhibited faster onset and higher amount of plastic deformation during compression than those containing gelatin. What is more, the Gurnham equation could be used as a substitute for the Kawakita equation in describing the compression properties of pharmaceutical tablets. Furthermore, the crushing strength, disintegration and dissolution times of the tablets increased with binder concentration, while friability values decreased. We noted that no significant differences in properties exist between formulations derived from the two binders (p > 0.05) exist. While tablets incorporating gelatin exhibited higher values for mechanical properties, Eucalyptus gum tablets had better balance between mechanical and release properties - as seen from the CSFR/Dt values. Tablets of good mechanical and release properties were prepared using Eucalyptus gum as a binder, and, therefore, it could serve as an alternative binder in producing tablets with good mechanical strength and fast drug release.

Mechanical Properties of Waxy Maize Starch Nanocrystal Reinforced Natural Rubber

2005 ◽  
Vol 38 (22) ◽  
pp. 9161-9170 ◽  
Author(s):  
Hélène Angellier ◽  
Sonia Molina-Boisseau ◽  
Alain Dufresne
Keyword(s):  
Mechanical Properties ◽  
Natural Rubber ◽  
Maize Starch ◽  
Waxy Maize

scholarly journals Influence of process variables on release properties of paracetamol tablets

2007 ◽  
Vol 57 (1) ◽  
pp. 73-86 ◽  
Author(s):  
Gbenga Alebiowu ◽  
Oludele Itiola
Keyword(s):  
Interaction Effects ◽  
Process Variables ◽  
Factorial Experimental Design ◽  
Disintegration Time ◽  
Individual Effects ◽  
Pregelatinized Starch ◽  
Tablet Formulations ◽  
Binder Concentration ◽  
The Individual ◽  
Paracetamol Tablet

Influence of process variables on release properties of paracetamol tablets A 23 factorial experimental design has been used to quantitatively study individual and interaction effects of the nature of binder (N), binder concentration (c) and relative density of tablet (d) on the disintegration time (DT) and dissolution times, t1, t50 and t90, of paracetamol tablet formulations. The factorial design was also used to study the quantitative effects of pregelatinization of starch binders on these parameters, i.e., N, c and d. In general, the most common ranking of the individual effects on DT, t1, t50 and t90 for native/native, pregelatinized/pregelatinized and native/pregelatinized starch binder formulations was c > d > N. For interaction effects, the most common ranking was N-c > c-d > N-d for all formulations. The results generally showed that c can considerably affect DT, t1, t50 and t90 of the tablets.

Preparation of Borax Cross-Linked Starch Nanoparticles for Improvement of Mechanical Properties of Maize Starch Films

2019 ◽  
Vol 67 (10) ◽  
pp. 2916-2925 ◽  
Author(s):  
Hao Lu ◽  
Na Ji ◽  
Man Li ◽  
Yanfei Wang ◽  
Liu Xiong ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Maize Starch ◽  
Starch Nanoparticles ◽  
Starch Films

Chrysophyllum albidum mucilage as a binding agent in paracetamol tablet formulations

2016 ◽  
Vol 46 (6) ◽  
pp. 565-573 ◽  
Author(s):  
Tolulope O. Ajala ◽  
Olufunke D. Akin-Ajani ◽  
Chinemerem Ihuoma-Chidi ◽  
Oluwatoyin A. Odeku
Keyword(s):  
Binding Agent ◽  
Tablet Formulations ◽  
Paracetamol Tablet

scholarly journals Mechanical properties of thermoplastic waxy maize starch

1996 ◽  
Vol 61 (11) ◽  
pp. 1927-1937 ◽  
Author(s):  
J. J. G. Van Soest ◽  
D. De Wit ◽  
J. F. G. Vliegenthart
Keyword(s):  
Mechanical Properties ◽  
Maize Starch ◽  
Waxy Maize
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