Double-blind, placebo-controlled, proof-of-concept trial of a kappa-selective opioid receptor antagonist augmentation in treatment-resistant depression

Maurizio Fava; Erica Mazzone; Marlene Freeman; Martina Flynn; Heidi Judge; Bettina Hoeppner; Rebecca S. Hock; Amy Shui; Matthew Macaluso; Mary F. Morrison; Linda L. Carpenter; Richard Shelton; John Zajecka; George I. Papakostas

doi:10.12788/acp.0003

Double-blind, placebo-controlled, proof-of-concept trial of a kappa-selective opioid receptor antagonist augmentation in treatment-resistant depression

Mapping Intimacies ◽

10.12788/acp.0003 ◽

2020 ◽

Vol 32 (4) ◽

Author(s):

Maurizio Fava ◽

Erica Mazzone ◽

Marlene Freeman ◽

Martina Flynn ◽

Heidi Judge ◽

...

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Proof Of Concept ◽

Treatment Resistant Depression ◽

Treatment Resistant ◽

Double Blind ◽

Double Blind Placebo ◽

Opioid Receptor Antagonist ◽

Resistant Depression

Download Full-text

PM308. A phase 3, multicenter randomized double blind placebo controlled study of the opioid receptor antagonist –Odelepran the treatment of alcohol addiction.

The International Journal of Neuropsychopharmacology ◽

10.1093/ijnp/pyw041.308 ◽

2016 ◽

Vol 19 (Suppl_1) ◽

pp. 10-10 ◽

Cited By ~ 1

Keyword(s):

Receptor Antagonist ◽

Opioid Receptor ◽

Alcohol Addiction ◽

Controlled Study ◽

Phase 3 ◽

Double Blind ◽

Double Blind Placebo ◽

Opioid Receptor Antagonist

Download Full-text

Repeat-dose ketamine augmentation for treatment-resistant depression with chronic suicidal ideation: A randomized, double blind, placebo controlled trial

Journal of Affective Disorders ◽

10.1016/j.jad.2018.09.037 ◽

2019 ◽

Vol 243 ◽

pp. 516-524 ◽

Cited By ~ 34

Author(s):

Dawn F. Ionescu ◽

Kate H. Bentley ◽

Matthias Eikermann ◽

Norman Taylor ◽

Oluwaseun Akeju ◽

...

Keyword(s):

Suicidal Ideation ◽

Controlled Trial ◽

Repeat Dose ◽

Treatment Resistant Depression ◽

Treatment Resistant ◽

Double Blind ◽

Double Blind Placebo ◽

Resistant Depression

Download Full-text

Minocycline as adjunctive treatment for treatment-resistant depression: study protocol for a double blind, placebo-controlled, randomized trial (MINDEP2)

BMC Psychiatry ◽

10.1186/s12888-020-02553-9 ◽

2020 ◽

Vol 20 (1) ◽

Cited By ~ 3

Author(s):

Muhammad Ishrat Husain ◽

Clare Cullen ◽

Madeha Umer ◽

Andre F. Carvalho ◽

Stefan Kloiber ◽

...

Keyword(s):

Randomized Trial ◽

Study Protocol ◽

Adjunctive Treatment ◽

Treatment Resistant Depression ◽

Treatment Resistant ◽

Double Blind ◽

Double Blind Placebo ◽

Resistant Depression

Download Full-text

Efficacy, safety, and tolerability of augmentation pharmacotherapy with aripiprazole for treatment-resistant depression in late life: a randomised, double-blind, placebo-controlled trial

The Lancet ◽

10.1016/s0140-6736(15)00308-6 ◽

2015 ◽

Vol 386 (10011) ◽

pp. 2404-2412 ◽

Cited By ~ 99

Author(s):

Eric J Lenze ◽

Benoit H Mulsant ◽

Daniel M Blumberger ◽

Jordan F Karp ◽

John W Newcomer ◽

...

Keyword(s):

Controlled Trial ◽

Late Life ◽

Treatment Resistant Depression ◽

Treatment Resistant ◽

Double Blind ◽

Double Blind Placebo ◽

Resistant Depression

Download Full-text

Reply to Dr Ng's Comments on "A Randomized, Double-Blind, Placebo-Controlled Trial of Augmentation With An Extended Release Formulation of Methylphenidate in Outpatients With Treatment-Resistant Depression"

Journal of Clinical Psychopharmacology ◽

10.1097/jcp.0b013e3181629990 ◽

2008 ◽

Vol 28 (1) ◽

pp. 117-118

Author(s):

Chi-Un Pae ◽

Prakash S. Masand ◽

Kathleen Peindl ◽

Christa Hooper-Wood ◽

Changsu Han ◽

...

Keyword(s):

Extended Release ◽

Controlled Trial ◽

Treatment Resistant Depression ◽

Treatment Resistant ◽

Double Blind ◽

Release Formulation ◽

Double Blind Placebo ◽

Extended Release Formulation ◽

Resistant Depression

Download Full-text

Transcranial direct current stimulation in treatment resistant depression: A randomized double-blind, placebo-controlled study

Brain Stimulation ◽

10.1016/j.brs.2011.08.005 ◽

2012 ◽

Vol 5 (3) ◽

pp. 242-251 ◽

Cited By ~ 119

Author(s):

U. Palm ◽

C. Schiller ◽

Z. Fintescu ◽

M. Obermeier ◽

D. Keeser ◽

...

Keyword(s):

Direct Current ◽

Transcranial Direct Current Stimulation ◽

Controlled Study ◽

Treatment Resistant Depression ◽

Treatment Resistant ◽

Double Blind ◽

Double Blind Placebo ◽

Direct Current Stimulation ◽

Resistant Depression

Download Full-text

Effect of Esketamine Nasal Spray on Olfactory Function and Nasal Tolerability in Patients with Treatment-Resistant Depression: Results from Four Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase III Studies

CNS Drugs ◽

10.1007/s40263-021-00826-9 ◽

2021 ◽

Author(s):

Richard L. Doty ◽

Vanina Popova ◽

Crystal Wylie ◽

Maggie Fedgchin ◽

Ella Daly ◽

...

Keyword(s):

Nasal Spray ◽

Olfactory Function ◽

Phase Iii ◽

Treatment Resistant Depression ◽

Treatment Resistant ◽

Double Blind ◽

Double Blind Placebo ◽

Resistant Depression ◽

Phase Iii Studies

Download Full-text

Double-blind, placebo-controlled, dose-ranging trial of intravenous ketamine as adjunctive therapy in treatment-resistant depression (TRD)

Molecular Psychiatry ◽

10.1038/s41380-018-0256-5 ◽

2018 ◽

Vol 25 (7) ◽

pp. 1592-1603 ◽

Cited By ~ 55

Author(s):

Maurizio Fava ◽

Marlene P. Freeman ◽

Martina Flynn ◽

Heidi Judge ◽

Bettina B. Hoeppner ◽

...

Keyword(s):

Adjunctive Therapy ◽

Treatment Resistant Depression ◽

Treatment Resistant ◽

Double Blind ◽

Double Blind Placebo ◽

Dose Ranging ◽

Resistant Depression ◽

Intravenous Ketamine

Download Full-text

Double-blind, proof-of-concept (POC) trial of Low-Field Magnetic Stimulation (LFMS) augmentation of antidepressant therapy in treatment-resistant depression (TRD)

Brain Stimulation ◽

10.1016/j.brs.2017.09.010 ◽

2018 ◽

Vol 11 (1) ◽

pp. 75-84 ◽

Cited By ~ 11

Author(s):

Maurizio Fava ◽

Marlene P. Freeman ◽

Martina Flynn ◽

Bettina B. Hoeppner ◽

Richard Shelton ◽

...

Keyword(s):

Magnetic Stimulation ◽

Antidepressant Therapy ◽

Proof Of Concept ◽

Treatment Resistant Depression ◽

Treatment Resistant ◽

Double Blind ◽

Low Field ◽

Resistant Depression

Download Full-text

Antidepressant and antisuicidal effects of ketamine on the functional connectivity of prefrontal cortex-related circuits in treatment-resistant depression: A double-blind, placebo-controlled, randomized, longitudinal resting fMRI study

Journal of Affective Disorders ◽

10.1016/j.jad.2019.08.022 ◽

2019 ◽

Vol 259 ◽

pp. 15-20 ◽

Cited By ~ 8

Author(s):

Mu-Hong Chen ◽

Wei-Chen Lin ◽

Pei-Chi Tu ◽

Cheng-Ta Li ◽

Ya-Mei Bai ◽

...

Keyword(s):

Prefrontal Cortex ◽

Functional Connectivity ◽

Treatment Resistant Depression ◽

Treatment Resistant ◽

Double Blind ◽

Double Blind Placebo ◽

Fmri Study ◽

Resistant Depression

Download Full-text