Transcranial Direct Current Stimulation as an Alternative Treatment in Patients with Alzheimer's Disease

2017 ◽  
Vol 10 (1) ◽  
Author(s):  
Yeo Jin Kim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Direct Current ◽  
Alternative Treatment ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation

High-Definition Transcranial Direct Current Stimulation Improves Delayed Memory in Alzheimer’s Disease Patients: A Pilot Study Using Computational Modeling to Optimize Electrode Position

2021 ◽  
pp. 1-17
Author(s):  
Ingrid Daae Rasmussen ◽  
Nya Mehnwolo Boayue ◽  
Matthias Mittner ◽  
Martin Bystad ◽  
Ole K. Grnli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Electric Field ◽  
Computational Modeling ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Cortical Atrophy ◽  
Brain Anatomy ◽  
High Definition ◽  
Direct Current Stimulation

Background: The optimal stimulation parameters when using transcranial direct current stimulation (tDCS) to improve memory performance in patients with Alzheimer’s disease (AD) are lacking. In healthy individuals, inter-individual differences in brain anatomy significantly influence current distribution during tDCS, an effect that might be aggravated by variations in cortical atrophy in AD patients. Objective: To measure the effect of individualized HD-tDCS in AD patients. Methods: Nineteen AD patients were randomly assigned to receive active or sham high-definition tDCS (HD-tDCS). Computational modeling of the HD-tDCS-induced electric field in each patient’s brain was analyzed based on magnetic resonance imaging (MRI) scans. The chosen montage provided the highest net anodal electric field in the left dorsolateral prefrontal cortex (DLPFC). An accelerated HD-tDCS design was conducted (2 mA for 3×20 min) on two separate days. Pre- and post-intervention cognitive tests and T1 and T2-weighted MRI and diffusion tensor imaging data at baseline were analyzed. Results: Different montages were optimal for individual patients. The active HD-tDCS group improved significantly in delayed memory and MMSE performance compared to the sham group. Five participants in the active group had higher scores on delayed memory post HD-tDCS, four remained stable and one declined. The active HD-tDCS group had a significant positive correlation between fractional anisotropy in the anterior thalamic radiation and delayed memory score. Conclusion: HD-tDCS significantly improved delayed memory in AD. Our study can be regarded as a proof-of-concept attempt to increase tDCS efficacy. The present findings should be confirmed in larger samples.

scholarly journals Transcranial Direct Current Stimulation Modulates Cortical Neuronal Activity in Alzheimer's Disease

2016 ◽  
Vol 10 ◽  
Author(s):  
Sara Marceglia ◽  
Simona Mrakic-Sposta ◽  
Manuela Rosa ◽  
Roberta Ferrucci ◽  
Francesca Mameli ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuronal Activity ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Direct Current Stimulation
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