scholarly journals Transcriptional cytokine responses associated with pathological outcomes in chickens experimentally infected with pigeon variant of avian avulavirus type 1

2021 ◽  
Vol 3 (1) ◽  
pp. 9
Author(s):  
Monika Olszewska-Tomczyk ◽  
Agnieszka Jasik
Keyword(s):  
Cytokine Responses

Epigenetic regulation of established human type 1 versus type 2 cytokine responses

2008 ◽  
Vol 121 (1) ◽  
pp. 57-63.e3 ◽  
Author(s):  
Ruey-Chyi Su ◽  
Allan B. Becker ◽  
Anita L. Kozyrskyj ◽  
Kent T. HayGlass
Keyword(s):  
Epigenetic Regulation ◽  
Human Type ◽  
Cytokine Responses

scholarly journals Susceptibility to Polyomavirus-Induced Tumors in Inbred Mice: Role of Innate Immune Responses

2002 ◽  
Vol 76 (19) ◽  
pp. 9657-9663 ◽  
Author(s):  
Palanivel Velupillai ◽  
John P. Carroll ◽  
Thomas L. Benjamin
Keyword(s):  
Antigen Presenting Cells ◽  
Interleukin 10 ◽  
Cytokine Response ◽  
Innate Immune ◽  
Interleukin 12 ◽  
Cytokine Responses ◽  
Induced Tumors ◽  
Antigen Presenting ◽  
Type 1 Cytokine

ABSTRACT Mice of the PERA/Ei strain (PE mice) are highly susceptible to tumor induction by polyomavirus and transmit their susceptibility in a dominant manner in crosses with resistant C57BR/cdJ mice (BR mice). BR mice respond to polyomavirus infection with a type 1 cytokine response and develop effective cell-mediated immunity to the virus-induced tumors. By enumerating virus-specific CD8+ T cells and measuring cytokine responses, we show that the susceptibility of PE mice is due to the absence of a type 1 cytokine response and a concomitant failure to sustain virus-specific cytotoxic T lymphocytes. (PE × BR)F1 mice showed an initial type 1 response that became skewed toward type 2. Culture supernatants of splenocytes from infected PE mice stimulated in vitro contained high levels of interleukin-10 and no detectable gamma interferon, while those from BR mice showed the opposite pattern. Differences in the innate immune response to polyomavirus by antigen-presenting cells in PE mice and BR mice led to polarization of T-cell cytokine responses. Adherent cells from spleens of infected BR mice produced high levels of interleukin-12, while those from infected PE and F1 mice produced predominantly interleukin-10. PE and F1 mice infected by polyomavirus responded with increases in antigen-presenting cells expressing B7.2 costimulatory molecules, whereas BR mice responded with increased expression of B7.1. Administration of recombinant interleukin-12 along with virus resulted in partial protection of PE mice and provided complete protection against tumor development in F1 animals.

scholarly journals IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses

Immunity ◽  
1996 ◽  
Vol 4 (5) ◽  
pp. 471-481 ◽  
Author(s):  
Jeanne Magram ◽  
Suzanne E Connaughton ◽  
Rajeev R Warrier ◽  
Daisy M Carvajal ◽  
Chang-you Wu ◽  
...  
Keyword(s):  
Cytokine Responses ◽  
Type 1 Cytokine ◽  
Deficient Mice

scholarly journals A Role for CD40-CD40 Ligand Interactions in the Generation of Type 1 Cytokine Responses in Human Leprosy

2000 ◽  
Vol 165 (3) ◽  
pp. 1506-1512 ◽  
Author(s):  
Paul S. Yamauchi ◽  
Joshua R. Bleharski ◽  
Koichi Uyemura ◽  
Jenny Kim ◽  
Peter A. Sieling ◽  
...  
Keyword(s):  
Cd40 Ligand ◽  
Cytokine Responses ◽  
Ligand Interactions ◽  
Type 1 Cytokine

Human type 1 CD4 T cell cytokine responses are selectively dependent on multidrug resistance protein1

2005 ◽  
Vol 115 (2) ◽  
pp. S255
Author(s):  
J. Zhang ◽  
M.A. Alston ◽  
H. Huang ◽  
R.A. Houghtling ◽  
R.W. Pastor ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
T Cell ◽  
Cd4 T Cell ◽  
Human Type ◽  
Cytokine Responses

Oral Lactoferrin Prevents Body Weight Loss and Increases Cytokine Responses during Herpes Simplex Virus Type 1 Infection of Mice

2004 ◽  
Vol 68 (3) ◽  
pp. 537-544 ◽  
Author(s):  
Hiroyuki WAKABAYASHI ◽  
Masahiko KUROKAWA ◽  
Kouichirou SHIN ◽  
Susumu TERAGUCHI ◽  
Yoshitaka TAMURA ◽  
...  
Keyword(s):  
Weight Loss ◽  
Body Weight ◽  
Herpes Simplex Virus ◽  
Herpes Simplex ◽  
Virus Type ◽  
Herpes Simplex Virus Type ◽  
Body Weight Loss ◽  
Cytokine Responses ◽  
Simplex Virus

Natural Antibodies Against Bone Morphogenic Proteins and Interferons in Healthy Donors and in Patients with Infections Linked to Type-1 Cytokine Responses

2011 ◽  
Vol 31 (9) ◽  
pp. 661-669 ◽  
Author(s):  
Melody Sauerborn ◽  
Esther van de Vosse ◽  
Diyar Delawi ◽  
Jaap T. van Dissel ◽  
Vera Brinks ◽  
...  
Keyword(s):  
Natural Antibodies ◽  
Bone Morphogenic Proteins ◽  
Cytokine Responses ◽  
Healthy Donors ◽  
Type 1 Cytokine
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