The Impact of Minimally Invasive Colostomy on the Microbial Infection of the Abdominal Cavity and the Development of Intoxication Syndrome in Patients with Rectal Cancer Complicated by Acute Obstruction

10.12737/7265 ◽  
2014 ◽  
Vol 21 (4) ◽  
pp. 38-40
Author(s):  
Тотиков ◽  
Z. Totikov ◽  
Тотиков ◽  
V. Totikov
Keyword(s):  
Rectal Cancer ◽  
Acute Phase ◽  
Microbial Contamination ◽  
Acute Phase Proteins ◽  
Abdominal Cavity ◽  
Minimal Access ◽  
Acute Obstruction ◽  
Microbial Infection ◽  
Proximal Colostomy ◽  
The Impact

The article studies the influence of proximal colostomy formed through minimal access for microbial contamination of the abdominal cavity during the radical phase of treatment and the dynamics of the inflammatory changes and intoxication syndrome in patients with rectal cancer complicated by acute obstruction. The research on microbial contamination of the abdominal cavity was made in 32 patients, including 15 patients in whom obstruction was resolved conservatively and 17 patients in whom was made a proximal colostomy through mini-invasive access to eliminate acute obstruction. In 30 patients were investigated acute phase proteins and determined the level of toxemia available by calculation leukocyte index of intoxication. Blood sampling was carried out in patients with acute intestinal obstruction directly before applying the proximal colostomy, and before the second - a radical step treatment in 7-10 days. Found that the imposition of the proximal colostomy through minimal access does not lead to an increase in microbial contamination of the abdomen; helps reduce the level of acute phase proteins, the level of general toxemia and reduces the risk of postoperative inflammatory complications before performing radical phase of treatment.

Abstract 1629: Genetic Polymorphism A1675G On Angiotensin Receptor Type 2, Is Implicated In The Expression Of Acute Phase Proteins And The Development Of Coronary Atherosclerosis In Hypertensive Patients

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Dimitris Tousoulis ◽  
Nikolas Koumallos ◽  
Charalambos Antoniades ◽  
Despina Kardara ◽  
Alexis S Antonopoulos ◽  
...  
Keyword(s):  
Genetic Polymorphism ◽  
Arterial Hypertension ◽  
Acute Phase ◽  
Coronary Atherosclerosis ◽  
Acute Phase Proteins ◽  
Renin Angiotensin System ◽  
Serum Levels ◽  
Hypertensive Patients ◽  
The Impact

Introduction: Renin-angiotensin system affects cardiovascular disease pathogenesis through a balance of angiotensin II effects on proatherogenic constitutive type 1 and antiatherogenic inducible type 2 (AT2R) receptors. The impact of A1675G polymorphism on the development of hypertension and advanced atherosclerosis is controversial. We examined the impact of A1675G polymorphism on AT2R, on the risk for arterial hypertension and coronary atherosclerosis, and its effect on the expression of proatherogenic inflammatory molecules. Methods. The study population consisted of 310 males: 145 with arterial hypertension and 165 controls, matched for age and risk factors for atherosclerosis. Among hypertensive subjects, 37 had angiographically documented coronary atherosclerosis and 108 had no evidence of atherosclerosis. The presence of A1675G polymorphism on AT2R gene (located in chromosome X) was determined by PCR. Serum levels of C-reactive protein and fibrinogen was measured in all the participants. Results. The frequency of the A allele was similar between patients with arterial hypertension (64/145, 44.1%) and non-hypertensive subjects (73/165, 44.2%, p=NS), while the risk for arterial hypertension was OR[95%CI]:1.004[0.641–1.574], p=0.985 for the G vs A carriers. However, the risk for coronary atherosclerosis within the group of hypertensive subjects was significantly elevated in the carriers of the A allele (OR[95%CI]:2.128[1.003–4.513], p=0.04 vs carriers of the G allele). Importantly, the presence of the A allele was also associated with significantly higher levels of CRP (4.8±0.8mg/dl) compared to the carriers of the G allele (3.0±0.3mg/dl, p<0.05). Similarly, fibrinogen levels were higher in A-allele carriers (median(25 th –75th percentile) 395(340 – 455) mg/ml) compared to G-allele carriers (369(320 – 406) mg/ml, p<0.05). Conclusions: Although genetic polymorphism A1675G on AT2R is not associated with the development of arterial hypertension, it affects the risk for coronary artery disease among hypertensive patients. The presence of the A allele also leads to higher levels of CRP and fibrinogen, implying that this polymorphism may induce atherogenesis by modulating acute phase response in hypertensive individuals.

scholarly journals Effect of Infection on Nutritional Status of Infants in a Cohort Study of Vitamin a in Western Kenya (P10-121-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Frederick Grant ◽  
Rose Wanjala ◽  
Jan Low ◽  
Carol Levin ◽  
Donald Coke ◽  
...  
Keyword(s):  
Cohort Study ◽  
Iron Deficiency ◽  
Vitamin A ◽  
Nutritional Status ◽  
Acute Phase ◽  
Acute Phase Proteins ◽  
Infection Prevalence ◽  
Subclinical Inflammation ◽  
Maternal Recall ◽  
The Impact

Abstract Objectives Infection is associated with impaired nutritional status especially of infants under 5 years old. We assessed the impact of infection indicated by both the acute phase proteins (APP), C-reactive protein (CRP) and α-1-acid glycoprotein (AGP), and as reported by maternal recall on the nutritional status of infants. Methods 505 pregnant women were enrolled into a nested longitudinal cohort study of vitamin A. Data analysis was restricted to infant data at 9-months (n = 385 mother-infant dyads) postpartum. Incidence and severity of respiratory infection and diarrhea over the previous 14 days were assessed by maternal recall; information on infant/child feeding practices were also collected. Infant weight, recumbent length and heel-prick capillary blood collection were taken at 9-months postpartum. Indicators of VA status [(retinol binding protein (RBP)], iron status (Hb, ferritin) and subclinical inflammation APP, CRP and AGP, were determined. Subclinical inflammation was defined as CRP >5 mg/L and/or AGP >1 g/L. Impacts of infection on infant nutritional status were estimated with multivariable logistic regression models adjusted for clustering and differences at enrollment. Results Infection prevalence, based on elevated CRP and AGP levels, was 36.7%. For diarrhea reported symptoms, 42.4% of infants at 9-months had no indication of infection as indicated by CRP and AGP; whilst for acute respiratory reported symptoms, 42.6% had no indication of infection. There was a weak but significant positive association with infection among VA deficient (RBP <0.83 µmol/L) infants based on maternal reported symptoms but not with iron deficiency (ferritin <12 µg/L). The odds of having infection, based on raised CRP and AGP, in underweight infants was 3.7 times higher (OR: 3.7; P = 0.019). Infants with iron deficiency were less likely (OR: 0.40; P = 0.001) to have infection based on CRP and AGP, whilst infants with VA deficiency were 5 times more likely (OR: 5.06; P = 0.0001) to have infection. Conclusions Acute phase proteins are more useful in defining infection in a population compared to reported symptoms of illness. Not controlling for inflammation in a population while assessing nutritional status might result in inaccurate prevalence estimation. Funding Sources Supported by the Bill &Melinda Gates Foundation (OPP53344).

scholarly journals Impact of radioiodine treatment on acute phase proteins in hyperthyroid cats

2021 ◽  
pp. 1098612X2110249
Author(s):  
Katharina Glück ◽  
Sabrina Mohrs ◽  
Katarina Hazuchova ◽  
Natali Bauer ◽  
Reto Neiger
Keyword(s):  
Acute Phase ◽  
Acute Phase Proteins ◽  
Fold Increase ◽  
Neoplastic Disease ◽  
Phase Reaction ◽  
Radioiodine Treatment ◽  
Serum Samples ◽  
Amyloid A ◽  
The Impact

Objectives The aim of this study was to investigate the impact of radioiodine treatment (RIT) on the acute phase proteins (APPs) serum amyloid A (SAA), alpha-1-acid glycoprotein (AGP) and haptoglobin (Hp) in hyperthyroid cats. Methods Between June 2013 and November 2014, 33 hyperthyroid cats without clinical or laboratory signs of inflammatory or neoplastic disease and a body weight >2.5 kg were enrolled. Immediately before, and 12, 36, 72 h and 6 days after RIT, serum samples were obtained for determination of APP concentrations. Results Both SAA and AGP concentrations changed significantly after RIT. The concentration of AGP increased gradually after treatment with a maximum concentration at the end of the study period (median baseline 398 μg/ml; median 6 days post-RIT 562 μg/ml [ P = 0.001]). A relevant >two-fold increase in AGP was seen in 8/33 (24%) cats. SAA concentration increased significantly within 12 h (baseline 9.2 μg/ml; 12 h post-RIT 22.5 μg/ml [ P = 0.012]). In 7/33 (21%) cats, a clinically relevant >10-fold increase in SAA was observed. Hp concentration showed no significant change ( P = 0.12). Conclusions and relevance RIT induced a mild, mainly not clinically relevant acute phase reaction (APR). AGP and SAA were useful APPs to determine RIT-induced APR.

Keratins 8/18 represent type II acute-phase proteins which are differentially regulated in human liver disease

2013 ◽  
Vol 51 (01) ◽  
Author(s):  
N Güldiken ◽  
V Usachov ◽  
K Levada ◽  
M Ziol ◽  
P Nahon ◽  
...  
Keyword(s):  
Liver Disease ◽  
Acute Phase ◽  
Human Liver ◽  
Acute Phase Proteins ◽  
Type Ii ◽  
Human Liver Disease

Changes of QT interval in the acute phase after pulmonary vein isolation for paroxysmal atrial fibrillation

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A Chikata ◽  
T Kato ◽  
K Ududa ◽  
S Fujita ◽  
K Otowa ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Pulmonary Vein ◽  
Female Patient ◽  
Pulmonary Vein Isolation ◽  
Acute Phase ◽  
Paroxysmal Atrial Fibrillation ◽  
Qt Interval ◽  
Qt Prolongation ◽  
Qtc Interval ◽  
The Impact

Abstract Introduction Pulmonary vein isolation (PVI) affects ganglionated plexi (GP) around the atrium, leading to a modification of the intrinsic cardiac autonomic system (ANS). In animal models, GP ablation has a potential risk of QT prolongation and ventricular arrhythmias. However, the impact of PVI on QT intervals in humans remains unclear. Purpose This study aims to evaluate the Impact of PVI on QT interval in patients with paroxysmal atrial fibrillation. Methods We analyzed consecutive 117 PAF patients for their first PVI procedures. 12-lead ECG was evaluated at baseline, 4 hr, day 1, 1 month, and 3 months after ablation. Only patients with sinus rhythm on 12-lead ECG at each evaluation point without antiarrhythmic drugs were included. Results Heart rate significantly increased at 4 hr, day 1, and 1 month. Raw QT interval prolonged at 4 hr (417.1±41.6 ms, P&lt;0.001) but shortened at day 1 (376.4±34.1 ms, P&lt;0.001), 1 month (382.2±31.5 ms, P&lt;0.001), and 3 months (385.1±32.8 ms, P&lt;0.001) compared to baseline (391.6±31.4 ms). Bazett- and Fridericia- corrected QTc intervals significantly prolonged at 4hr (Bazett: 430.8±27.9 ms, P&lt;0.001; Fridericia: 425.8±27.4 ms, P&lt;0.001), day1 (Bazett: 434.8±22.3 ms, P&lt;0.001; Fridericia: 414.1±23.7 ms, P&lt;0.001), 1M (Bazett: 434.8±22.3 ms, P&lt;0.001; Fridericia: 408.2±21.0 ms, P&lt;0.05), and 3M (Bazett: 420.1±21.8 ms, P&lt;0.001; Fridericia: 407.8±21.1 ms, P&lt;0.05) compared to baseline (Bazett: 404.9±25.2 ms; Fridericia: 400.0±22.6 ms). On the other hand, Framingham- and Hodges- corrected QTc interval significantly prolonged only at 4hr (Framingham: 424.1±26.6 ms, P&lt;0.001; Hodges: 426.8±28.4 ms, P&lt;0.001) and at day1 (Framingham: 412.3±29.3 ms, P&lt;0.01; Hodges: 410.6±40.2 ms, P&lt;0.05) compared to baseline (Framingham: 399.2±22.7 ms; Hodges: 400.7±22.8 ms). At 4 hr after ablation, raw QT and QTc of all formulas significantly prolonged than baseline. Raw QT and QTc prolongation at 4hr after ablation were more frequently observed in female patients. Multiple regression analysis revealed that female patient is a significant predictor of raw QT and QTc interval prolongation of all formulas 4hr after PVI. Conclusions Raw QT and QTc prolonged after PVI, especially in the acute phase. Female patient is a risk factor for QT prolongation in the acute phase after PVI. Funding Acknowledgement Type of funding source: None

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