scholarly journals INFLUENCE OF DISTURBED CONDITIONS OF REPARATIVE REGENERATION OF BONE TISSUE ON THE DYNAMICS OF THYROID HORMONES

2016 ◽  
Vol 1 (4) ◽  
pp. 109-114 ◽  
Author(s):  
Курганский ◽  
Ilya Kurganskiy ◽  
Родионова ◽  
Lyubov Rodionova ◽  
Зарицкая ◽  
...  
Keyword(s):  
Thyroid Hormones ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Normal Values ◽  
Gradual Increase ◽  
Reparative Regeneration ◽  
Bone Tissue Regeneration ◽  
Regeneration Of Bone Tissue ◽  
Peripheral Conversion ◽  
Regeneration Of Bone

Managing bone tissue regeneration is a key problem in traumatology and orthopedics. The researches proved that thyroid hormones affect hemostasis and reparative regeneration of bone tissue favorably and promote osteogenesis and bone consolidation.The aim of this research is to study the influence of disturbed reparative regeneration on the concentration of thyroid hormones in blood in the dynamics. Experimental research on rabbits (n=12) with modelling of disturbed reparative regeneration revealed disorder in thyroid hormones synthesis and different directions of T3 and unbound T3 production on the 35th day when the maxi-mum decrease of T3 (2times) and unbound T3 (1.5times) compared to normal values was registered. The analysis of production of T4 and unbound T4 revealed suppression of the values from the 1st to 50th day and gradual increase in unbound T4 from the 50th day. The most significant manifestation of thyroid gland reaction on the disturbed reparative regeneration of shin bones was the decrease in T3 and peripheral conversion of thyroid hormones up to 50th day with formation of false joint in these terms.

scholarly journals New strategies in bone tissue regeneration via application of magnetomechanical transduction

2021 ◽  
Vol 6 ◽  
pp. 5-11
Author(s):  
T.N. Zamay ◽  
◽  
T.V. Tolmacheva ◽  
Keyword(s):  
Magnetic Field ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Tissue Regeneration ◽  
Reparative Regeneration ◽  
Bone Tissue Regeneration ◽  
Targeted Agents ◽  
Clinical Conditions ◽  
New Strategies ◽  
Concise Description

Reparative regeneration is one of the key problems in traumatology and orthopaedics. Despite the fact that bone regeneration is a self-regulatory physiological process of bone formation, complex clinical conditions require additional enhancement of bone regeneration – either local or systemic. This review provides a concise description of main stages of reparative regeneration. The search was performed in PubMed and e-LIBRARY databases among papers published between 2000 and 2021. Main strategies presently used for acceleration of bone tissue regeneration and limitations of their application are presented. This review gives a detailed description of one of the most promising means for bone tissue regeneration enhancement. Namely, magnetomechanic transduction of magnetic nanoparticles using functionalised targeted agents in an alternating magnetic field that induces osteogenic differentiation of mesenchymal stem cells.

scholarly journals Bioactive Calcium Phosphate-Based Composites for Bone Regeneration

2021 ◽  
Vol 5 (9) ◽  
pp. 227 ◽  
Author(s):  
Marta Tavoni ◽  
Massimiliano Dapporto ◽  
Anna Tampieri ◽  
Simone Sprio
Keyword(s):  
Bone Tissue ◽  
Mechanical Performance ◽  
Calcium Phosphates ◽  
Ceramic Composites ◽  
Bone Tissue Regeneration ◽  
Multi Scale ◽  
Regeneration Of Bone Tissue ◽  
Manufacturing Techniques ◽  
Size And Morphology ◽  
Regeneration Of Bone

Calcium phosphates (CaPs) are widely accepted biomaterials able to promote the regeneration of bone tissue. However, the regeneration of critical-sized bone defects has been considered challenging, and the development of bioceramics exhibiting enhanced bioactivity, bioresorbability and mechanical performance is highly demanded. In this respect, the tuning of their chemical composition, crystal size and morphology have been the matter of intense research in the last decades, including the preparation of composites. The development of effective bioceramic composite scaffolds relies on effective manufacturing techniques able to control the final multi-scale porosity of the devices, relevant to ensure osteointegration and bio-competent mechanical performance. In this context, the present work provides an overview about the reported strategies to develop and optimize bioceramics, while also highlighting future perspectives in the development of bioactive ceramic composites for bone tissue regeneration.

scholarly journals Effect of melatonin on reparative regeneration of bone tissue in the jaw bones experiment

2020 ◽  
Vol 15 (4) ◽  
Author(s):  
Evgeny Shchetinin ◽  
Ekaterina Sergeevna Sirak ◽  
Galina Aleksandrovna Afanaseva ◽  
Gregory Petrosyan ◽  
Elizaveta Evgenievna Shchetinina ◽  
...  
Keyword(s):  
Bone Tissue ◽  
Reparative Regeneration ◽  
Jaw Bones ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Regeneration of bone tissue under implantation of sapphire with titanium coating

2014 ◽  
Vol 0 (3) ◽  
pp. 24 ◽  
Author(s):  
Volodymyr Filipenko ◽  
Inna Batura ◽  
Anatoliy Andreyev ◽  
Оleksey Marushchak
Keyword(s):  
Bone Tissue ◽  
Titanium Coating ◽  
Regeneration Of Bone Tissue ◽  
Regeneration Of Bone

Vitamin D Effects on Guided Bone Regeneration and Osseointegration of Dental Implants (Literature Review)

2020 ◽  
Vol 75 (5) ◽  
pp. 552-560
Author(s):  
Sergey Yu. Ivanov ◽  
Svetlana Yu. Kalinchenko ◽  
Nidjat A. Guseynov ◽  
Aleksander A. Muraev ◽  
Aigul Т. Safi ◽  
...  
Keyword(s):  
Vitamin D ◽  
Bone Tissue ◽  
Dental Implants ◽  
Scientific Data ◽  
Reparative Regeneration ◽  
Jaw Bone ◽  
Dental Implantation ◽  
Oral Reconstruction ◽  
Phosphate Exchange ◽  
Regeneration Of Bone

Background.Due to the prevalence of Vitamin D deficiency as well as the frequency of reconstructive surgical interventions followed by dental implantation, the issue arises concerning the effect of Vitamin D on reparative regeneration of bone and osseointegration of dental implants.The purpose using literature data we are conducting an impact assessment of vitamin D on reparative regeneration of bone tissue, in particular, after oral reconstruction surgeries and dental implantation.Methods.Retrieval, systematization and analysis of scientific data on application of vitamin D supplementation and its effect on reparative regeneration of jaw bone tissue.The conclusions.For the most part, the positive effect exerted on reparative regeneration of jaw bone tissue and osseointegration of dental implants is due to the role of vitamin D in physiological processes evolving in bone tissue, namely maintenance of calcium and phosphate exchange through intestinal absorption and TNF, RANKL (Receptor activator of nuclear factor kappa-B ligand) and consequently differentiation of precursors to osteoclasts into osteoclasts through VDR stimulation (VitaminD Receptor) receptors for further osteogenesis. Also, according to literature data, FGF23 (Fibroblast Growth Factor) protein is a marker of osteoblasts differentiation into osteocytes, it is also known that FGF23 and 1,25(ОН)2D3 are genetically related. FGF23 is the main regulator of both phosphate exchange in bones and metabolism of vitamin D and its metabolites. Besides, indirect anti-inflammatory effect has been observed thanks to inhibition of pro-inflammatory cytokine secretion. Taking into account the abovementioned data, of particular relevance is the definition of serum concentration 25(ОН)D and development of schemes of vitamin D level pre-surgery correction in patients, who have to undergo oral reconstruction surgeries and dental implantation. Mass spectrometry is a promising diagnostic method for determining the level of vitamin D in a body, as it allows to identify the actual amount of vitamin D free from admixture of other steroid hormones. The introduction of this method into clinical practice will allow to monitor the level of vitamin D in patients, receiving reconstructive and rehabilitative treatment.

Sign in / Sign up

Export Citation Format

Share Document