The study on tolerability and efficacy of the new complex drug «Helmintal tablets» based on moxidectin and praziquantel

2016 ◽  
Vol 3 (3) ◽  
pp. 403-408
Author(s):  
Степанов ◽  
V. Stepanov ◽  
Арисова ◽  
G. Arisova ◽  
Смирнова ◽  
...  
Keyword(s):  
Body Weight ◽  
Body Temperature ◽  
Body Mass ◽  
Therapeutic Dose ◽  
Biochemical Parameters ◽  
Drug Efficacy ◽  
The Body ◽  
Before And After ◽  
And Control ◽  
Complex Drug

Objective of research: the study on tolerability and therapeutic efficacy of the complex drug Helmintal produced on the basis of two ingredients moxidectin and praziquantel. Materials and methods: In our research, we used four drug modifications: for cats and kittens weighting less than 4 kg (moxidectin 0.4 mg and praziquantel 10 mg); for cats — more than 4 kg (moxidectin 1.6 mg and praziquantel 40 mg); for dogs and puppies — less than 10 kg (moxidectin 1 mg and praziquantel 25 mg); for dogs — more than 10 kg (moxidectin 5 mg and praziquantel 125 mg.) To study the effect of the drug on the organism, three groups of clinically healthy animals were formed (5 animals per group): dogs 1 — 2 years of age with the body mass 18 — 20 kg; puppies 3 — 5 weeks of age weighting 0.8 — 1 kg; cats 1 — 2 years of age weighting 3 — 5 kg; kittens 6 — 8 weeks of age with the body mass 0.6 — 0.8 kg. The drug was given to animals orally once a day in the morning within 7 days in the following doses: the first experimental group — 0.4 mg moxidectin and praziquantel 10 mg per 1 kg of body weight (double therapeutic dose); the second group — moxidectin 1.0 mg and praziquantel 25 mg per 1 kg of body weight (five-fold therapeutic dose); the third group served as controls — the drug was not used. During the experiment, animals were monitored daily, their general health status, behavior, appetite were observed, weight and body temperature controlled. Before and 15 and 30 days after the beginning of the drug taking, several morphological and biochemical parameters of blood and urine were investigated. The study of the anthelmintic efficacy of the drug was carried out on the basis of veterinary clinics in Moscow and Moscow region. Altogether 205 cats and 209 dogs spontaneously infected were chosen for the experiment. The diagnosis and the drug efficacy were confirmed based on the clinical picture and on Fulleborn’s method used for detection of helminth eggs in animal’s feces followed by differentiation. Results and discussion: During the study on the drug tolerance it was found that the general status, mass and the body temperature of animals from experimental groups did not significantly differ from controls. Morphological and biochemical parameters of blood and urine in all animals from experimental and control groups did not differ significantly and were within the physiological norm before and after treatment. Thus, the research allows to conclude that the drug applied within 7 days at double and fivefold therapeutic doses has no adverse effect on dogs, puppies, cats and kittens. Most sick animals used in the experiment on the effectiveness of the drug, were emaciated, listless, their fur was ruffled, mucous membranes were pale; they suffered from anal itching, diarrhea and fecal retention. The drug was given after diagnosis; many dogs and cats ate it themselves, and other had no problems with eating pills due to their small size and pleasant taste. When applying the drug and throughout the experiment, no side effects and complications were observed in all animals. 10 and 20 days after giving the drug, its efficacy in the treatment of nematodosis and cestodosis of adult dogs cats as well as kittens and puppies was 100%.

scholarly journals Resistance of Fry from Vaccinated Mother of Gift Tilapia (Oreochromis niloticus Linn.) to Artificial Infection of Streptococcus iniae

2007 ◽  
Vol 3 (1) ◽  
pp. 37 ◽  
Author(s):  
I. Nur ◽  
. Sukenda ◽  
D. Dana
Keyword(s):  
Body Weight ◽  
Oreochromis Niloticus ◽  
Body Fluid ◽  
Challenge Test ◽  
The Body ◽  
Streptococcus Iniae ◽  
Soluble Extract ◽  
Before And After ◽  
Antibody Titers ◽  
And Control

<p>An investigation was made to study the efficacy of dosage and time of administration in maternal vaccination. Mothers of nile tilapia were vaccinated by intraperitoneal injection with adjuvant-heat killed <em>Streptococcus iniae </em>at one and two weeks after spawning at the dosages of 0,2 ml/kg and 0,4 ml/kg body weight. Unvaccinated mothers were used as control. Agglutinating antibody titers in the blood plasma of mothers before and after spawning, eggs soluble extract, the body fluid of fry at 5, 10 and 15 days post hatching (DPH) were examined. The protective immunity of fry was tested by challenge test, the survival rate (SR) and the relative percent survival (RPS) offish within 7 days was observed. There was no difference in the antibody level of mothers, eggs soluble extract, and the body fluid of fry at 5, 10 and 15 DPH from vaccinated mothers at one or two weeks after spawning. However, antibody of mothers, eggs and fry from vaccinated mothers at the dosage of 0,4 ml/kg body weight were higher than the dosage of 0,2 ml/kg body weight and control. Antibody titre. of fry of vaccinated mothers at 5, 10 and 15 DPH were (-log2=2,88), (-log2=2,53) and (-log2=2,07) respectively, while SR were 89%, 94% and 92% respectively. SR of control fry were lower 7%, 10% and 12% respectively than fry from vaccinated mother; meanwhile RPS were 47%. 76% and 77% respectively.</p> <p>Key words: Maternal immunity. <em>Streptococcus iniae, Oreochromis niloticus, </em>vaccination, antibody</p> <p> </p> <p>ABSTRAK</p> <p>Suatu studi tentang efikasi dari dosis dan waktu pemberian vaksin pada vaksinasi lewat induk dilakukan. Induk ikan nila <em>(Oreochromis niloticus) </em>diberi vaksin melalui injeksi intraperitoneal dengan "adjuvant-heat killed <em>Streptococcus iniae" </em>satu minggu sesudah memijah dan dua minggu sesudah memijah dengan dosis 0,2 ml/kg dan 0,4 ml/kg bobot tubuh. Aglutinasi titer antibodi dari plasma darah induk sebelum dan sesudah memijah, ekstrak terlarut telur, dan cairan tubuh pada 5, 10 dan 15 hari setelah menetas (DPH) diperiksa. Imunitas dari larva diuji dengan uji tantang, kelangsungan hidup (SR) dalam 7 hari setelah uji tantang diamati. Hasil menunjukkan bahwa tidak ada perbedaan pada level antibodi dari induk, ekstrak terlarut telur dan cairan tubuh dari larva pada 5, 10 dan 15 DPH dari induk yang diberi vaksin pada satu atau dua minggu setelah memijah. Akan tetapi, level antibodi induk, ekstrak terlarut telur dan cairan tubuh larva dari induk-induk yang diberi vaksin dengan dosis 0.4 ml/kg bobot tubuh lebih tinggi dari 0.2 ml/kg bobot tubuh dan kontrol. Level antibodi dari larva yang berasal dari induk yang diberi vaksin dengan dosis 0.2 ml/kg, 0.4 ml/kg dan kontrol adalah (-log2=2.5), (-log2=2.9) dan (-log2=2). Sedangkan kelangsungan hidupnya masing-masing 95%, 94% dan 84%.</p> Kata kunci: Imunitas induk. <em>Streptococcus iniae, Oreochromis niloticus, </em>vaksinasi, antibodi

scholarly journals Effects of Triphala on Lipid and Glucose Profiles and Anthropometric Parameters: A Systematic Review

2021 ◽  
Vol 26 ◽  
pp. 2515690X2110110
Author(s):  
Wiraphol Phimarn ◽  
Bunleu Sungthong ◽  
Hiroyuki Itabe
Keyword(s):  
Body Mass Index ◽  
Body Weight ◽  
Blood Glucose ◽  
Waist Circumference ◽  
Lipid Profile ◽  
Body Mass ◽  
The Body ◽  
Current Evidence ◽  
Diabetic Patients ◽  
Anthropometric Parameters

Aim. The efficacy of triphala on lipid profile, blood glucose and anthropometric parameters and its safety were assessed. Methods. Databases such as PubMed, ScienceDirect, Web of Science, and Thai Library Integrated System (ThaiLIS) were systematically searched to review current evidence of randomized controlled trials (RCT) on triphala. RCTs investigating the safety and efficacy of triphala on lipid profile, blood glucose and anthropometric parameters were included. Study selection, data extraction, and quality assessment were performed independently by 2 authors. Results. Twelve studies on a total of 749 patients were included. The triphala-treated groups showed significantly reduced low-density lipoprotein-cholesterol, total cholesterol and triglyceride in 6 studies. Five RCTs demonstrated triphala-treated groups led to statistically significant decrease in body weight, body mass index and waist circumference of obese patients. Moreover, triphala significantly decreased fasting blood glucose level in diabetic patients but not in people without diabetes. No serious adverse event associated with triphala was reported during treatment. Conclusions. This review summarized a current evidence to show triphala might improve the lipid profile, blood glucose, the body weight, body mass index and waist circumference under certain conditions. However, large well-designed RCTs are required to confirm this conclusion.

scholarly journals Clinical and in Vivo Response Following Surgery or Surgery Plus Adjuvant Chemotherapy or Immunotherapy for Colorectal Carcinoma in a Rat Model

1983 ◽  
Vol 76 (10) ◽  
pp. 833-840 ◽  
Author(s):  
A K House ◽  
M A L Maley
Keyword(s):  
Body Weight ◽  
Adjuvant Chemotherapy ◽  
Surgical Excision ◽  
The Body ◽  
Recurrent Tumour ◽  
Mesenteric Node ◽  
And Control ◽  
Tumour Weight

Two cohorts of rats, 240 with colon cancer and 150 controls, were assessed clinically and immunologically for their response to tumour and its management which was either by surgical excision alone or by surgical excision combined with either adjuvant chemotherapy or immunotherapy. The histology and invasion characteristics were observed for similarity with those of human lesions. Metastases were found in liver, lymph nodes, the peritoneum or lungs in 27% of animals during follow up. Significantly fewer adjuvant-treated rats had metastases than those receiving surgery alone ( P < 0.05), and less total tumour weight was found in the adjuvant-treated rats at four ( P < 0.03) and six ( P < 0.001) weeks postoperatively. Animals in the adjuvant immunotherapy group survived longer than in either other group ( P < 0.001). The crude parameters of host response to tumour, body, spleen and mesenteric lymph node weight were recorded and the latter two indexed to body weight. The body weight of tumour and control rats increased significantly with time ( P < 0.04). The spleen and mesenteric node indices were significantly ( P < 0.04) greater in tumour than control rats and were varied by recurrent tumour growth and by the adjuvant treatment administered postoperatively.

scholarly journals Antiobesity and Hypolipidemic Activity of Moringa oleifera Leaves against High Fat Diet-Induced Obesity in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Souravh Bais ◽  
Guru Sewak Singh ◽  
Ramica Sharma
Keyword(s):  
Body Weight ◽  
Body Temperature ◽  
Total Cholesterol ◽  
High Fat Diet ◽  
Moringa Oleifera ◽  
Chronic Administration ◽  
The Body ◽  
Atherogenic Index ◽  
High Fat ◽  
Diet Induced Obesity

In the present study, the methanolic extract of Moringa oleifera leaves (MEMOL) was evaluated for antiobesity activity in rats. The antiobesity potential of MEMOL was studied against high fat diet-induced obesity (HFD) in rats. In this study, chronic administration of HFD in rats produced hypercholesterolemia (116.2 ± 0.27 mg/dL), which led to an increase in the body weight (225 gr), total cholesterol, triglycerides (263.0 ± 4.69 mg/dL), and attenuation in the levels of HDL (34.51 ± 2.20 mg/dL) as well as changes in body temperature of animals. Treatment of obese rats with MEMOL for 49 days resulted in a significant (P<0.001) change in body weight, total cholesterol, triglycerides, and LDL level along with a significant (P<0.001) increase in body temperature as compared to the HFD-induced obesity. MEMOL treated rats also showed a significant decrease in the level of liver biomarkers, organ weight, and blood glucose level. Further, rats treated with MEMOL (200 mg and 400 mg/kg) show reduced atherogenic index (1.7 ± 0.6 and 0.87 ± 0.76). The results indicate that the rats treated with Moringa oleifera (MO) have significantly attenuated the body weight without any change in the feed intake and also elicited significant thermogenic effect and to act as hypolipidemic and thermogenic property in obesity related disorders.

Significance of graded doses of aqueous seed extract of Moringa oleifera (L) on live body weight, gonadal, extragonadal dimensions and sperm reserves of Yankasa rams

2021 ◽  
pp. 33-40
Keyword(s):  
Body Weight ◽  
Moringa Oleifera ◽  
Seed Extract ◽  
The Body ◽  
Control Group ◽  
Live Body Weight ◽  
And Control ◽  
Standard Techniques ◽  
Different Doses ◽  
Apparently Healthy

The aim of the study was to investigate the effects of Moringa oleifera aqueous seed extract on live body weight, gonadal and extragonadal dimensions and sperm reserves of Yankasa rams. Twenty five apparently healthy Yankasa rams aged 1-2 years and weighing 19.0 ± 2.1 Kg were used for the study. The rams were randomly selected into five groups: A, B, C, D and E with five rams in each group as treatment and control groups respectively. Groups A - D were given oral dose of Moringa oleifera aqueous seed extract at a dose rate of 1000, 2000, 3000, 4000 (mg/kg), respectively while group E was given 10 ml/kg water orally, daily for five months. Live body weight, gonadal and extragonadal reserves were determined according to standard techniques. The results showed a significant increase in live body weight in the months of April to June among rams treated with different doses of Moringa oleifera aqueous seed extract compared with the control group. The control group showed no significant differences in the body weight, gonadal and extragonadal dimensions and sperm reserves. In conclusion, the treatment of Yankasa rams with Moringa oleifera aqueous seed extract increased live body weight, but had no significant effects on gonadal and extragonadal dimensions and sperm reserves in Yankasa rams. Therefore, it is recommended that M. oleifera aqueous seed extract can be used at doses of 2000mg/kg to 3000mg/kg in Yankasa rams for optimum gain in live body weight.

scholarly journals Morphometric characteristics of the patellar tendon

2016 ◽  
Vol 69 (suppl. 1) ◽  
pp. 53-58
Author(s):  
Milodrag Vranjes ◽  
Ivan Vukasinovic ◽  
Mirko Obradovic ◽  
Mile Bjelobrk ◽  
Zlatko Budinski ◽  
...  
Keyword(s):  
Anterior Cruciate Ligament ◽  
Body Weight ◽  
Body Mass ◽  
Patellar Tendon ◽  
Cruciate Ligament ◽  
The Body ◽  
Professional Athletes ◽  
Morphometric Characteristics ◽  
Significant Difference ◽  
Anterior Cruciate

Introduction. The most common injuries of the knee joint are injuries of the anterior cruciate ligament. The golden standard in reconstruction of this ligament is graft bone - patellar tendon - bone. Knowing the morphometric characteristics of these ligaments is crucial for anterior cruciate ligament reconstruction. This study was aimed at determining morphometric characteristics of the patellar tendon in vivo, measured intraoperatively, and at defining the correlation between the obtained values and body weight, height, gender and sport activity among different groups of athletes. Material and Methods. This study included 184 patients suffering from anterior cruciate ligament injuries who were admitted to the Clinical Center of Vojvodina, Department of Orthopedics and Traumatology. Results. The patellar tendon width ranged from 28 mm to 43 mm, averaging at 32.02 mm. The length of the patellar tendon ranged from 35 mm to 62 mm, averaging at 46.34 mm. The thickness of the patellar tendon ranged from 3 mm to 6 mm, averaging at 3.78 mm. The measured results were positively and statistically relevant with the body mass, height and body mass index. Discussion and Conclusion. The patellar tendon was thicker, longer and wider in persons with higher values of body weight and height. Men have statistically longer, thicker and wider patellar tendon than women. There was no statistically significant difference between morphometric characteristics of the patellar tendon among professional athletes and recreational athletes, neither was there one in the obtained geometric data of the patellar tendon among tested groups of professional athletes.

Hydration Status in Adolescent Judo Athletes Before and After Training in the Heat

2012 ◽  
Vol 7 (1) ◽  
pp. 39-46 ◽  
Author(s):  
Anita M. Rivera-Brown ◽  
Roberto A. De Félix-Dávila
Keyword(s):  
Body Mass ◽  
Training Session ◽  
Well Being ◽  
Sodium Concentration ◽  
High Heat ◽  
The Body ◽  
Hydration Status ◽  
Before And After ◽  
Judo Athletes ◽  
Sweat Sodium

Adolescent judo athletes who train in tropical climates may be in a persistent state of dehydration because they frequently restrict fluids during daily training sessions to maintain or reduce their body weight and are not given enough opportunities to drink.Purpose:Determine the body hydration status of adolescent judo athletes before, immediately after, and 24 h after (24H) a training session and document sweat Na+ loss and symptoms of dehydration.Methods:Body mass and urine color and specific gravity (USG) were measured before, after, and 24 h after a training session in a high-heat-stress environment (29.5 ± 1.0°C; 77.7 ± 6.1% RH) in 24 adolescent athletes. Sweat sodium loss was also determined. A comparison was made between mid-pubertal (MP) and late pubertal (LP) subjects.Results:The majority of the subjects started training with a significant level of dehydration. During the training session, MP subjects lost 1.3 ± 0.8% of their pretraining body mass whereas LP subjects lost 1.9 ± 0.5% (P < .05). Sweat sodium concentration was 44.5 ± 23.3 mmol/L. Fluid intake from a water fountain was minimal. Subjects reported symptoms of dehydration during the session, which in some cases persisted throughout the night and the next day. The 24H USG was 1.028 ± 0.004 and 1.027 ± 0.005 g/mL for MP and LP, respectively.Conclusions:Adolescent judo athletes arrive to practice with a fluid deficit, do not drink enough during training, and experience symptoms of dehydration, which may compromise the quality of training and general well-being.

scholarly journals PRE AND POSTPRANDIAL THERMOGRAPHIC PROFILE OF GREEN IGUANAS (IGUANA IGUANA)

2016 ◽  
Vol 73 (2) ◽  
pp. 425
Author(s):  
Simona Rusu ◽  
Zdenek Knotek ◽  
Radu Lacatus ◽  
Ionel Papuc
Keyword(s):  
Heat Transfer ◽  
Body Temperature ◽  
Temperature Difference ◽  
The Body ◽  
Significant Difference ◽  
Before And After ◽  
Significant Temperature ◽  
Green Iguanas ◽  
The Right ◽  
Head Temperature

Abstract The body temperature of 10 clinically healthy green iguanas (Iguana iguana) was measured using a thermographic camera (FLIR E6, Flir Systems Sweden) before and after the food was offered. For each animal there were performed a total of 6 measurements (3 before feeding and 3 after the food was offered). The purpose of this experiment was to observe the thermographic pattern of the body before and after the feeding, since herbivore reptiles tend to bask after the feeding to increase the body temperature that will help them afterwards digest the food. The animals were housed in individual vivariums with every animal having a basking spot available. The pictures were taken outside the vivarium in an adjacent room. The animals were handled with gloves and transported in a cardboard box in order to avoid heat transfer between the handler and the iguana that would have produced thermal artefacts. Each individual was placed on a table on a styrofoam slate, again, to avoid the heat transfer between the table and the animal`s body. For each animal a total of 4 pictures were taken (up, front, left and right). The pictures were analysed with the FLIR Tools program that is provided by the manufacturer and 3 temperatures were taken into consideration (the head temperature, body temperature on the right side and body temperature on the left side). The temperatures were compared between them and with the temperature of the vivariums that consisted of the average between the temperature in 3 different spots (basking spot, the feeding bowl site and the coldest spot) measured with an infrared thermometer GM300 (Benetech, China). The temperature of the body was dependent on the vivarium temperature and it was a significant temperature difference between the measurements before the feeding and after the feeding. Also we discovered a significant difference between the head temperature and the body temperature on the left side before the feeding that disappeared after the animals ate. There was also a significant difference between the temperature on right side and on left side of the animals both before and after the feeding. No significant temperature difference was observed between the head and the right side of the body neither before nor after the feeding.

scholarly journals The Clinical and Hematological changes in Rabbits exposed to Melia azedarach fruits under experimental conditions

2015 ◽  
Vol 1 (1) ◽  
pp. 12 ◽  
Author(s):  
AL- Zubaedi Raad Mahmood
Keyword(s):  
Body Weight ◽  
Body Temperature ◽  
Bleeding Time ◽  
Hematological Parameters ◽  
The Body ◽  
Melia Azedarach ◽  
Control Group ◽  
Clotting Time ◽  
Experimental Conditions ◽  
Hb Concentration

The study was conducted on 10 local breed rabbits, of 1-2 years age, of 1- 1.5 kg body weight. They were feed concentrated and green food, and left ad libitum for water, and kept in room of 20- 25 oC. The animals divided into two groups of 5 each. First as treated group received the plant in powder form mixed with the food at a dose rate of 5 g/ animal / day for three weeks , while the second left without exposure as a control group .The main dependent parameters in the study were , clinical parameters ( body temperature , heartbeat , respiratory rate, body weight , in addition to monitor any abnormal signs appear on the animals . While the main hematological parameters were included , RBC count , WBC count , Hb concentration,PCV percentage , Red cell indices , Bleeding time and Clotting time. The body temperature, respiratory rates, heart rate were increased .The body weight decreased .The bleeding time and clotting time were prolonged. The erythrocyte count, Hb concentration, and MCV values were decreased; PCV and MCHC did not showed any significant changes. The MCH increased. The total leucocytes count and the basophiles percentage did not showed any significant changes. The Heterophils and monocytes percentage increased .The lymphocytic and Eosinophil percentage were decreased during the study.

Sign in / Sign up

Export Citation Format

Share Document