scholarly journals URINARY TRACT INFECTIONS: EPIDEMIOLOGY, ETIOLOGY, PATHOGENESIS, RISK FACTORS, DIAGNOSIS (REVIEW)

2016 ◽  
Vol 1 (1) ◽  
pp. 70-74
Author(s):  
Плеханов ◽  
Aleksandr Plekhanov ◽  
Дамбаев ◽  
Arsalan Dambaev
Keyword(s):  
Risk Factors ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Proteus Mirabilis ◽  
Gold Standard ◽  
E Coli ◽  
The Moment ◽  
Tract Infections

Urinary tract infections are one of the most common inflammatory disorders of urinary tract that occurs in 40 % of all cases of nosocomial infections. This pathology more often occurs in women, 50 % of them have urinary tract infection at least once in a lifetime. Urinary tract infections are chronic, pluricausal and frequently recurrent diseases. During many decades E. coli was considered to be main pathogenetic flora plated from urine at the urinary tract. Statistically Proteus mirabilis is ranked number two in the degree of incidence. At the moment the researches pay closer attention to Candida pathogens. Urinary tract infections appear in consequence of ingress of microorganisms in urinoexcretory system by ascending, hematogenic and lymphogenic ways. Culture-based, microbiologic study of urine with pathogen isolation and estimation of the bacteriuria degree is the gold standard of diagnostics of urinary tract infections.

URINARY INFECTION AT DEPARTMENT OF UROLOGY OF HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL

2018 ◽  
pp. 100-108
Author(s):  
Dinh Khanh Le ◽  
Dinh Dam Le ◽  
Khoa Hung Nguyen ◽  
Xuan My Nguyen ◽  
Minh Nhat Vo ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Urine Culture ◽  
Clinical Manifestations ◽  
University Hospital ◽  
E Coli ◽  
Positive Urine ◽  
Tract Infections

Objectives: To investigate clinical characteristics, bacterial characteristics, drug resistance status in patients with urinary tract infections treated at Department of Urology, Hue University Hospital. Materials and Method: The study was conducted in 474 patients with urological disease treated at Department of Urology, Hue Universiry Hospital from July 2017 to April 2018. Urine culture was done in the patients with urine > 25 Leu/ul who have symptoms of urinary tract disease or infection symptoms. Patients with positive urine cultures were analyzed for clinical and bacterial characteristics. Results: 187/474 (39.5%) patients had symptoms associated with urinary tract infections. 85/474 (17.9%) patients were diagnosed with urinary tract infection. The positive urine culture rate was 45.5%. Symptoms of UTI were varied, and no prominent symptoms. E. coli accounts for the highest proportion (46.67%), followed by, Staphycoccus aureus (10.67%), Pseudomonas aeruginsa (8,0%), Streptococcus faecali and Proteus (2.67%). ESBL - producing E. coli was 69.23%, ESBL producing Enterobacter spp was 33.33%. Gram-negative bacteria are susceptible to meropenem, imipenem, amikacin while gram positive are vancomycin-sensitive. Conclusions: Clinical manifestations of urinary tract infections varied and its typical symptoms are unclear. E.coli is a common bacterium (46.67%). Isolated bacteria have a high rate of resistance to some common antibiotics especially the third generation cephalosporins and quinolones. Most bacteria are resistant to multiple antibiotics at the same time. Gram (+) bacteria are susceptible to vancomycin, and gram (-) bacteria are susceptible to cefoxitin, amikacin, and carbapenem. Key words: urinary tract infection

scholarly journals Infeções do Trato Urinário numa Coorte de Transplantados Renais

2014 ◽  
Vol 27 (3) ◽  
pp. 364 ◽  
Author(s):  
Ana Bispo ◽  
Milene Fernandes ◽  
Cristina Toscano ◽  
Teresa Marques ◽  
Domingos Machado ◽  
...  
Keyword(s):  
Risk Factors ◽  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Hospital Admissions ◽  
Female Gender ◽  
Tract Infections

<strong>Introduction:</strong> Urinary tract infection is the most common infectious complication following renal transplantation and its frequency is insufficiently studied in Portugal. The aim of this study was to characterize the incidence of urinary tract infections and recurrent urinary tract infections in renal transplant recipients.<br /><strong>Material and Methods:</strong> This was a retrospective cohort observational study, obtained from clinical files of all patients who received a renal transplant at the Hospital of Santa Cruz, from January 2004 to December 2005, with a mean follow-up period of five years or until date of graft loss, death or loss of follow-up. After a descriptive analysis of the population, we used bivariate tests to identify risk factors for urinary tract infections.<br /><strong>Results:</strong> A total of 127 patients were included, with a 593 patients.year follow-up. We detected 53 patients (41.7%) presenting with at least one episode of urinary tract infection; 21 patients (16.5%) had recurrent urinary tract infection. Female gender was the only risk factor associated with the occurrence of urinary tract infections (p &lt; 0.001, OR = 7.08, RR = 2.95) and recurrent urinary tract infections (p &lt; 0.001, OR = 4.66, RR = 2.83). Escherichia coli (51.6%), Klebsiella pneumoniae (15.5%) and Enterobacter spp (9.9%) were the<br />most frequently identified pathogens. Patients did not reveal an increased mortality or allograft loss. However, urinary tract infections were the most important cause of hospital admissions.<br /><strong>Discussion:</strong> Female gender was the only risk factor for urinary tract infections in this population. Escherichia coli was the most frequent agent isolated.<br /><strong>Conclusion:</strong> Despite preventive measures, urinary tract infections remain an important cause of morbidity and hospital admissions.<br /><strong>Keywords:</strong> Urinary Tract Infections; Postoperative Complications; Risk Factors; Kidney Transplantation; Portugal.

scholarly journals Risk factors of multidrug-resistant bacteria in community-acquired urinary tract infections

2021 ◽  
Vol 21 (1) ◽  
pp. 214-9
Author(s):  
Ertugrul Guclu ◽  
Fikret Halis ◽  
Elif Kose ◽  
Aziz Ogutlu ◽  
Oğuz Karabay
Keyword(s):  
Risk Factors ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Multidrug Resistant ◽  
Antibiotic Usage ◽  
Advanced Age ◽  
History Of ◽  
Tract Infections

Background: Urinary tract infections (UTIs) are one of the most seen infection among community. Objectives: In this cross-sectional study we aimed to investigate the risk factors of multidrug-resistant (MDR) bacteria that caused community-acquired UTI (CA-UTI). Methods: Consecutive patients admitted to the Urology and Infectious Diseases policlinics with the diagnosis of CA-UTI were included in the study. A standard form including possible predisposing factors for MDR bacteria was applied. Results: In total, 240 patients (51.3% females) were enrolled in the study. The mean age of participants were 59.8 ± 18.3 years old. Escherichia coli (n =166; 69.2%)was the most frequently isolated bacteria and its incidence was higher in females than in males (p=0.01). In total, 129 (53.8%) of the identified pathogens were MDR bacteria. According to multivariate analysis, the use of antibiotics three or more times increased the risk of infection with MDR bacteria by 4.6 times, the history of urinary tract infection in the last 6 months by 2 times, being male and over 65 years old by 3 times. Conclusion: Doctors should consider prescribing broad-spectrum antibiotics in patients with severe UTIs with a history of UTI, advanced age, male gender, and multiple antibiotic usage, even if they have a CA-UTI. Keywords: Urinary tract infection; community acquired; multidrug-resistant; male; multiple antibiotic usage; advanced age.

scholarly journals Urinary tract infection in Children Hospitalized at Constanta Clinical Infectious Diseases Hospital

2017 ◽  
Vol 23 (4) ◽  
pp. 175-179
Author(s):  
Anca Daniela Pînzaru ◽  
Raluca Mihai ◽  
Octavia Burcea ◽  
Simona Claudia Cambrea
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Infectious Diseases ◽  
Urinary Tract Infections ◽  
E Coli ◽  
Unexplained Fever ◽  
High Incidence ◽  
Important Health ◽  
Tract Infections

AbstractIntroduction: In pediatrics, the urinary tract infection is one of the most frequent bacterial infection, representing an important health problem due to its high incidence, wide etiology, asymptomatic evolution, and multiple and sever complications, relapses and sequelae.” Material and Method: We evaluated 45 children, aged between 6 months and 16 years, diagnosed and treated for urinary tract infection at the Clinical Infectious Diseases Hospital, of Constanta County, in a period of 3 years and 6 months. Results: During studied period, between January 2014 and June 2017 from a total of 9343 patients admitted to the Constanta Clinical Infectious Diseases Hospital, we selected 45 children (4.81‰) diagnosed with urinary tract infection. The average age of children with urinary tract infections was 5 years and 5 months. The gender distribution revealed a 2:1 balance in girl’s favor. The most affected group of age was 1-3 years. Fever was the dominating symptom. Urine cultures were positive for 37 cases, meanwhile for eight cases had been negative. The predominant germs are E. coli for female and for male Proteus. We noticed that for E. coli the highest sensitivity is preserved to Ertapenem -15 cases, followed by Ceftriaxone and Ciprofloxacin -10 cases each, and Gentamycin -9 cases. Conclusions: Pediatric urinary tract infection should be considered in every patient under 3 years with unexplained fever.

scholarly journals Risk factors of the fungal urinary tract infections

2021 ◽  
pp. 178-184
Author(s):  
N. V. Sturov ◽  
S. V. Popov ◽  
I. Yu. Shmelkov
Keyword(s):  
Risk Factors ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Fungal Infections ◽  
Antifungal Drugs ◽  
Main Role ◽  
Tract Infections

The role of fungi as causative agents of infections is growing. In in-patients, especially at intensive care units, fungal infections might cause serious problems. Studies conducted over recent years shows an increase of fungi detection in urine in in-patients from 5,01 up to 10,63%. Most often, the appearance of fungi in the urine connected with contamination or colonization of the urinary tract. However, in immunocompromised patients, this could be the part of urinary tract infection and even of disseminated fungal process. Candida is the most common cause of fungal urinary tract infections. At the same time, the presence of Candida in urine (candiduria) not always comes with clinical signs of urethritis, cystitis and pyelonephritis. Detection of noCandida albicans agents in urine is increasing, new Candida species revealed are resistant to antifungal drugs so risk of complications is increasing. Recent researches reveal new mechanisms of how Candida interacts with the bacteria that cause urinary infections. The main mechanisms of Candida virulence factors are dimorphism, adhesion proteins — Als1-7,9 and Gls, invasion enzymes — phospholipase, Als3 and Ssa1, as well as enzymes that neutralize reactive oxygen species. The most significant risk factors of fungal urinary tract infection are the presence of a urinary catheter, diabetes mellitus, immunosuppression and previous antibiotic intake. The study of the formation process of the cellular and immune response to Candida makes it possible to identify the main links in the pathogenesis of urinary tract candidiasis, as well as the main role of immunosuppression in the development of the disease.

scholarly journals Community-Acquired Urinary Tract Infection byEscherichia coliin the Era of Antibiotic Resistance

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Dong Sup Lee ◽  
Seung-Ju Lee ◽  
Hyun-Sop Choe
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Antibiotic Resistance ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Oral Antibiotics ◽  
Antibiotic Resistant ◽  
E Coli ◽  
Tract Infections

Urinary tract infections (UTIs) caused byEscherichia coli (E. coli)are the most common types of infections in women. The antibiotic resistance ofE. coliis increasing rapidly, causing physicians to hesitate when selecting oral antibiotics. In this review, our objective is to ensure that clinicians understand the current seriousness of antibiotic-resistantE. coli, the mechanisms by which resistance is selected for, and methods that can be used to prevent antibiotic resistance.

scholarly journals Enterococcus faecalispromotes innate immune suppression and polymicrobial catheter-associated urinary tract infection

2017 ◽  
Author(s):  
Brenda Yin Qi Tien ◽  
Hwee Mian Sharon Goh ◽  
Kelvin Kian Long Chong ◽  
Soumili Bhaduri-Tagore ◽  
Sarah Holec ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Enterococcus Faecalis ◽  
Urinary Tract Infections ◽  
Host Immunity ◽  
E Coli ◽  
Tract Infections ◽  
Polymicrobial Infections

AbstractEnterococcus faecalis, a member of the human gastrointestinal microbiota, is an opportunistic pathogen associated with hospital-acquired wound, bloodstream, and urinary tract infections.E. faecaliscan subvert or evade immune-mediated clearance, although the mechanisms are poorly understood. In this study, we examinedE. faecalis-mediated subversion of macrophage activation. We observed thatE. faecalisactively prevents NF-κB signaling in mouse RAW264.7 macrophages in the presence of Toll-like receptor agonists and during polymicrobial infection withEscherichia coli.E. faecalisandE. colico-infection in a mouse model of catheter-associated urinary tract infection (CAUTI) resulted in a suppressed macrophage transcriptional response in the bladder compared toE. coliinfection alone. Finally, we demonstrated that co-inoculation ofE. faecaliswithE. coliinto catheterized bladders significantly augmentedE. coliCAUTI. Taken together, these results support thatE. faecalissuppression of NF-κB-driven responses in macrophages promotes polymicrobial CAUTI pathogenesis.Author SummarySynergistic polymicrobial infections can contribute to both disease severity and persistence.Enterococcus faecalisandEscherichia coliare frequently co-isolated from polymicrobial urinary tract infections. Immunomodulation by co-infecting microbes can result in a more permissive environment for pathogens to establish infection. Presently, we do not yet understand how these microbes overcome host immunity to establish polymicrobial infections. To address this, we investigated how the immunosuppressive function ofE. faecaliscan contribute to acute infection. We defined thatE. faecalisis able to suppress macrophagesin vitro, despite the presence ofE. coli. We also demonstratedE. faecalis’ability to augmentE. colititersin vivoto establish kidney infection. Our findings raise the prospect thatE. faecaliscan alter host immunity to increase susceptibility to other uropathogens.

Evolution of the Antimicrobial resistance of Bacteria causing Urinary Tract Infections

2021 ◽  
Vol 24 ◽  
Author(s):  
Khonaw Kader Salh
Keyword(s):  
Escherichia Coli ◽  
Drug Resistance ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Multiple Drug Resistance ◽  
Childbearing Age ◽  
E Coli ◽  
Tract Infections

Background: The bacteria, Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae), are the main reasons for urinary tract infections (UTIs). This research aimed to investigate the isolation of etiologic agents from patients with UTI; it also investigates the antibiotic resistance activities and incidence of ESBL genes between different clinical separates of uropathogenic E. coli, determining their association with ESBL genes. Methods: The study enrolled 1000 positive growth isolates. The predominant pathogen associated with urinary tract infection, Gram-negative, were the main isolates from UTI patients, including E. coli, K. pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Staphylococcus aureus and Enterococcus faecalis. Results: Among suspicious cases of urinary tract infection, we showed that 15.2% of the patients had UTI, and female patients in the childbearing age group were more affected. 644 E. coli (64.4%) and 322 (32.2%) K. pneumoniae were more isolated. Among 936 (93.6%) ESBL producing bacteria, 614 (61.4 %) E. coli showedhigh resistance to the antibiotics, Cefotaxime (85.7 %), Cefepime (85.7 %), Ciprofloxacin (83.1 %) and Kanamycin (77.9 %). Most ESBL-producing K. pneumoniae were multidrug-resistant (MDR). Nitrofurantoin, gentamycin, and imipenem were the most effective antibiotics for ESBL-producing E. coli isolates. Conclusion: This study shows that the high rates of MDR Escherichia coli infection in our hospital were frequentative reasons for UTI. Nitrofurantoin and aminoglycosides were the most beneficial first-line drugs to be applied in the cases of UTI. It is recommended to conduct regular investigations on the drug resistance of all isolates and formulate helpful antibiotic treatment policies in China. It is important to determine the prevalence of ESBL in urine E. coli and K. pneumoniae isolates because it has a great influence on the selection of suitable antibacterial agents. In short, more than half of ESBL producers have multiple drug resistance (MDR).

Diagnostic Accuracy of Urine Analysis (DR) in Suspicious Cases of Urinary Tract Infections by Taking Urine Culture as Gold Standard

2021 ◽  
Vol 15 (12) ◽  
pp. 3494-3497
Author(s):  
Akhtar Ali ◽  
Shahzad Ali ◽  
Naresh Kumar Valecha ◽  
Saeed Ahmed Khan
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Diagnostic Accuracy ◽  
Urinary Tract Infections ◽  
Gold Standard ◽  
Urine Analysis ◽  
Urine Culture ◽  
Suspected Case ◽  
Tract Infections

Background: Urinary tract infections (UTI) are one of common clinical condition encountered in various clinical settings. This the most common infection, typically diagnosed on the basis history and clinical examination endorsed by urine analysis and culture sensitivity. Timely diagnosis and treatment are crucial in management. For diagnosis of UTI, Urine culture is standard, as it provide detail information for urinary pathogens, but it has certain disadvantages e.g. urine culture is costly, takes longer time, and up to 60-80% of the results are negative. Objective: To determine the diagnostic accuracy of urinalysis (Urine DR) in detection of urinary tract infection (UTI) among suspected cases of UTI by taking urine culture as gold standard. Materials And Methods: This cross sectional study was conducted at study was conducted at Department of Urology, Jinnah Postgraduate Medical Centre (JPMC) Karachi, from march 2021 to September 2021. All patients who visited to JPMC Karachi and fulfilled the inclusion criteria and were included in the study after getting Informed consent. All patients were evaluated by urinalysis and urine culture. The results of urinalyses were recorded and compared with the results obtained on subsequent urine cultures. All of the specimens were obtained by the “clean-catch” method. All data and results were recorded on proforma and used electronically for research purpose. Results: Mean ± SD of age was 52.6±8.5 years. In distribution of gender, 60 (53.1%) patients were male while 53 (46.9%) were female patients. Diagnostic accuracy of urinalysis was 73.45% in diagnosis of urinary tract infection with sensitivity 76.47%, specificity 72.15% PPV 54.17% and NPV was found to be 87.69% by using urine culture findings as gold standard. Conclusion: It is to be concluded that evaluating of urinary tract infection (UTI) with urinalysis (Urine DR) did not prove helpful and comparable to urine culture. Urine culture should be done in each and every suspected case of UTI. Keywords: Bacteriuria, Diagnostic Accuracy, Sensitivity, Specificity, Urinalysis

Factors associated with nosocomial urinary tract infections in maternity wards of public hospitals in Lubumbashi in DR Congo

2021 ◽  
Vol 5 (2) ◽  
Keyword(s):  
Risk Factors ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Urinary Tract Infections ◽  
Public Hospitals ◽  
Hospital Environment ◽  
Factors Associated ◽  
Nosocomial Urinary Tract Infection ◽  
Tract Infections

Introduction: Nosocomial urinary tract infection represents between 30 and 50% of all these nosocomial infections. It occupies the first place and constitutes the third entry point for bacteremia. The objective of our study was to identify the risk factors associated with nosocomial urinary tract infections in maternity wards of public hospitals in Lubumbashi. Method: We carried out an analytical cross-sectional study in which the population consisted of parturients who did not have a urinary tract infection on admission. The urine samples were taken and analyzed in the laboratory of the university clinics of Lubumbashi. A case of nosocomial urinary tract infection was defined according to the WHO definition. To collect this urine, the parturients did it themselves after a health education session. Two samples were taken, one at the entry and the other at the exit of the parturient from the maternity hospital. The univariate analysis used the prevalence ratio as an indicator of risk with a 95% confidence interval and the bivariate analysis included all risk factors that had a significance level p ˂ 0.05 by a regression model binary logistics. Results: Out of the total of 1240 parturients selected and who were distributed in seven maternities of public hospitals in the city of Lubumbashi. It was noted that women who gave birth at HGR Kampemba were up to ten times more likely to develop nosocomial urinary tract infection than those who did at HGR Kisanga. An association was observed between delivery with complications (p = 0.032), long length of stay (p <0.001), delivery with surgical intervention (p <0.001) and antibiotic therapy (p = 0.020). Conclusion: Nosocomial urinary tract infections were varied depending on the characteristics of health structures, characteristics of parturients and health care. It is necessary to improve the hospital hygiene of the personnel, the hospital environment and the materials as well as a good policy of use of the antibacterials.

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