Homeostasis and Evolution From the Standpoint of the Third Paradigm

2015 ◽  
Vol 22 (3) ◽  
pp. 33-39
Author(s):  
Филатова ◽  
O. Filatova ◽  
Еськов ◽  
Valeriy Eskov ◽  
Хадарцев ◽  
...  

According to new theory of chaos - self organization if was presented new paradigm of homeostasis and evolution. Numerical investigation of tremor, miogram, encephalograms, heart-rate, etc. proved the simultaneously changing of experimental results as dx/dt=0 for the special human state vector x(t) for different interval of time At. The statistical function of x(t) -fix) present the simultaneously changing of/(x). So the homeostasis seems as a stationary regime when the parameters of quasi-attractor are not change. The authors present the new interpretation of homeostasis and evolution for special systems with special dynamic of living system (hymen lodi special). Then the first place take the x(t) parameters of such special third type of system.

10.12737/3328 ◽  
2014 ◽  
Vol 21 (1) ◽  
pp. 138-141
Author(s):  
Еськов ◽  
Valeriy Eskov ◽  
Филатова ◽  
O. Filatova

The understanding of very special systems of third type was created according to W.Weaver efforts. The new theory of chaos – self- organization was created last 40 years and was based on other understanding of stationary mode of third type of systems and its very specific chaotic behavior. The analog of the systems with physical system was discussed too. The third type of systems (opposite of deterministic and stochastic systems) was presented. It was discussed the principle distinguishes between dynamics of such system and traditional systems according to Heisenberg uncertainty principle. Traditional systems have certain and reproducible initial state of its system’s state vector and we can predict its future states. But in the third type of systems the authors have uncertain initial system state and uncertain vector states. It is a unique system which I.R. Prigogine in his famous article to the future generation determines as systems behind the science. The time for researching of such systems has come. For the modeling of biosystems, the authors propose method of quasi-attractor and define five special properties of complex systems. The main of it is connected with uninterrupted chaotic movements (glimmering property) of system’s vector in phase space of state and evolution of such system’s state vector in phase space of state. It was demonstrated that Heizenberg principle of uncertainty has special analog at theory of chaos – self organization. The botton boarder of the left side of inequality for the systems of third type the authors propose the value of quasiattractors, inside of it we chaos uninferrupled and chaotic movements of systems state vector. The value of quasiattractor determine like multiplication of coordinat x its speed dx/dt.


1988 ◽  
Vol 102 ◽  
pp. 79-81
Author(s):  
A. Goldberg ◽  
S.D. Bloom

AbstractClosed expressions for the first, second, and (in some cases) the third moment of atomic transition arrays now exist. Recently a method has been developed for getting to very high moments (up to the 12th and beyond) in cases where a “collective” state-vector (i.e. a state-vector containing the entire electric dipole strength) can be created from each eigenstate in the parent configuration. Both of these approaches give exact results. Herein we describe astatistical(or Monte Carlo) approach which requires onlyonerepresentative state-vector |RV> for the entire parent manifold to get estimates of transition moments of high order. The representation is achieved through the random amplitudes associated with each basis vector making up |RV>. This also gives rise to the dispersion characterizing the method, which has been applied to a system (in the M shell) with≈250,000 lines where we have calculated up to the 5th moment. It turns out that the dispersion in the moments decreases with the size of the manifold, making its application to very big systems statistically advantageous. A discussion of the method and these dispersion characteristics will be presented.


1996 ◽  
Author(s):  
James A. McCubbin ◽  
Erma J. Lawson ◽  
Jeffrey J. Sherman ◽  
Jane A. Norton

2007 ◽  
Vol 49 (5A) ◽  
pp. A177-A193 ◽  
Author(s):  
P Martin ◽  
L Marrelli ◽  
A Alfier ◽  
F Bonomo ◽  
D F Escande ◽  
...  

2021 ◽  
Author(s):  
Fatemeh Sarhaddi ◽  
Iman Azimi ◽  
Anna Axelin ◽  
Hannakaisa Niela-Vilen ◽  
Pasi Liljeberg ◽  
...  

BACKGROUND Heart rate variability (HRV) is a non-invasive method reflecting autonomic nervous system (ANS) regulations. Altered HRV is associated with adverse mental or physical health complications. ANS also has a central role in physiological adaption during pregnancy causing normal changes in HRV. OBJECTIVE Assessing trends in heart rate (HR) and HRV parameters as a non-invasive method for remote maternal health monitoring during pregnancy and three months postpartum. METHODS Fifty-eight pregnant women were monitored using an Internet-of-Things (IoT)-based remote monitoring system during pregnancy and 3-months postpartum. Pregnant women were asked to continuously wear Gear sport smartwatch to monitor their HR and HRV. In addition, a cross-platform mobile application was utilized for collecting pregnancy-related information. The trends of HR and HRV parameters were extracted using reliable data. We also analyzed the trends of normalized HRV parameters based on HR to remove the effect of HR changes on HRV trends. Finally, we exploited hierarchical linear mixed models to analyze the trends of HR, HRV, and normalized HRV parameters. RESULTS HR increased significantly during the second trimester (P<.001) and decreased significantly during the third trimester (P<.01). Time-domain HRV parameters, average normal interbeat intervals (AVNN), standard deviation of normal interbeat intervals (SDNN), root mean square of the successive difference of normal interbeat intervals (RMSSD), normalized SDNN (nSDNN), and normalized RMSSD (nRMSSD) decreased significantly during the second trimester (P<.001) then increased significantly during the third trimester (P<.01). Some of the frequency domain parameters, low-frequency power (LF), high-frequency power (HF), and normalized HF (nHF) decreased significantly during the second trimester (P<.01), and HF increased significantly during the third trimester (P<.01). In the postpartum period, nRMSSD decreased (P<.05), and the LF to HF ratio (LF/HF) increased significantly (P<.01). CONCLUSIONS Our study showed that HR increased and HRV parameters decreased as the pregnancy proceeded, and the values returned to normal after the delivery. Moreover, our results show that HR started to decrease while time-domain HRV parameters and HF started to increase during the third trimester. Our results also demonstrate the possibility of continuous HRV monitoring in everyday life settings.


2020 ◽  
Vol 21 (Supplement_1) ◽  
Author(s):  
L Esposito ◽  
R Sorrentino ◽  
V Capone ◽  
C Santoro ◽  
M Lembo ◽  
...  

Abstract Background Overweight and obesity are related to the risk of new-onset atrial fibrillation (AF). Peak atrial longitudinal strain (PALS) is an advanced echocardiographic parameter of left atrial (LA) function with a recognized diagnostic and prognostic role in both the general population and AF. Purpose To investigate the impact of body mass index (BMI) on LA function by utilizing standard and advanced echocardiography in patients with non-valvular AF. Methods In the NeAfib-Echo registry, 395 consecutive adult patients with non-valvular AF (F/M: 175/220; mean age 70.6 ± 11 years, BMI: 27.8 ± 5.6 kg/m²) were enrolled. 215 patients (54.1%) had permanent/persistent AF (prAF) and 178 (45.9%) had paroxysmal AF (pxAF). Anthropometric parameters and blood pressure (BP) were recorded and CHA2DS2VASc score was calculated. Patients underwent a complete echo-Doppler exam, including determination of PALS and left ventricular (LV) global longitudinal strain (GLS) (both reported in absolute values). The overall population was divided according to BMI tertiles: first tertile &lt;25.3 Kg/m² (n = 127); second tertile 25.3-29 Kg/m² (n = 137); third tertile &gt; 29.3 Kg/m² (n = 130). Results No significant difference of sex prevalence, age, systolic BP and heart rate was found among the three BMI tertiles, whereas diastolic BP was higher in the third tertile (p &lt; 0.001). CHA2DS2VASc score did not significantly differ among tertiles. In the pooled population LV mass index (LVMi) (p = 0.001) progressively increased from the first to the third tertile (p &lt; 0.001), whereas LA volume index, LV ejection fraction (EF), GLS and E/e" ratio were not significantly different among the three groups. PALS was lower in third tertile (14.3 ± 8.2%) versus both the first (19.0 ± 11.5%) and the second tertile (17.7 ± 10.6%) (p &lt; 0.002). In separate sub-analyses according to AF type, PALS was significantly lower in the first than the third tertile in the PxAF group (p &lt; 0.01) but not in patients with PrAF (p = 0.158). In the pooled population PALS was significantly related with BMI (r= -0.17, p &lt; 0.001) (Figure) but also with age, heart rate, LVMi, LV EF, GLS, E/e’ ratio and pulmonary artery systolic pressure (PAPS). By a multilinear regression analysis, after adjusting for CHA2DS2VASc score, LV mass index, LV EF, E/e’ ratio and PAPs, BMI remained independently associated with PALS (standardized β coefficient = -0.127, p &lt; 0.02) (cumulative R² =0.41, SEE = 8.5%, p &lt; 0.0001). Conclusions In patients with non valvular AF, overweight and obesity exert a detrimental effect on LA function as testified by the gradual PALS reduction with the increase of BMI tertiles. BMI is associated with PALS independently of several confounders including CHA2DS2VASc. Besides CHA2DS2VASc score, BMI could be considered as an additional factor for evaluating cardiovascular risk in non valvular AF. Abstract P814 Figure. Relation between BMI and PALS


2012 ◽  
Vol 27 (7) ◽  
pp. 794 ◽  
Author(s):  
Young-Sun Park ◽  
Jeong-Kyu Hoh ◽  
Moon-Il Park

2019 ◽  
Author(s):  
David Alexander Urrego-Higuita

Every living system consumes energy for its growth and development processes, in the human being it becomes a research paradigm, where the aim is to determine the interaction of man with his environment and the transformation of the energy coming from food.For your study there are different techniques which differ in their level of specialization, cost and accuracy, these are divided into predictive, estimating and measurement. For this project a system that seeks to determine the energy consumption during different states is developed, due to the variability of conditions in which the study of energy consumption is developed, different techniques are established such as indirect calorimetry and the conditions for the evaluation by means of accelerometers and the study of heart rate, where a record of the related variables is made through a computational applicationFinally, the behavior of the prototype in different resting states is evaluated, as well as the evaluation of the sensors used in indirect calorimetry, where evaluation tests of the gas sensors and calibration protocol for the flow sensor are defined.


2021 ◽  
Author(s):  
Merav Mofaz ◽  
Matan Yechezkel ◽  
Grace Guan ◽  
Margaret L. Brandeau ◽  
Tal Patalon ◽  
...  

AbstractBackgroundThe rapid rise in hospitalizations associated with the Delta-driven COVID-19 resurgence, and the imminent risk of hospital overcrowding, led the Israeli government to initialize a national third (booster) COVID-19 vaccination campaign in early August 2021, offering the BNT162b2 mRNA vaccine to individuals who received their second dose over five months ago. However, the safety of the third (booster) dose has not been fully established yet.ObjectiveEvaluate the short-term, self-reported and physiological reactions to the third BNT162b2 mRNA COVID-19 (booster) vaccine dose.DesignA prospective observational study, in which participants are equipped with a smartwatch and fill in a daily questionnaire via a dedicated mobile application for a period of 21 days, starting seven days before the vaccination.SettingAn Israel-wide third (booster) vaccination campaign.ParticipantsA group of 1,609 (18+ years of age) recipients of at least one dose of the BNT162b2 vaccine between December 20, 2020, and September 15, 2021, out of a larger cohort of 2,912 prospective study participants. 1,344 of the participants were recipients of the third vaccine dose.MeasurementsDaily self-reported questionnaires regarding local and systemic reactions, mood level, stress level, sport duration, and sleep quality. Heart rate, heart rate variability and blood oxygen saturation level were continuously measured by Garmin Vivosmart 4 smartwatches.ResultsThe extent of systemic reactions reported following the third (booster) dose administration is similar to that reported following the second dose (p-value=0.305) and considerably greater than that reported following the first dose (p-value<0.001). Our analyses of self-reported well-being indicators as well as the objective heart rate and heart rate variability measures recorded by the smartwatches further support this finding. Focusing on the third dose, reactions were more apparent in younger participants (p-value<0.01), in women (p-value<0.001), and in participants with no underlying medical conditions (p-value<0.001). Nevertheless, reported reactions and changes in physiological measures returned to their baseline levels within three days from inoculation with the third dose.LimitationsParticipants may not adequately represent the vaccinated population in Israel and elsewhere.ConclusionOur work further supports the safety of a third COVID-19 BNT162b2 mRNA (booster) vaccine dose from both a subjective and an objective perspective, particularly in individuals 65+ years of age and those with underlying medical conditions.Primary funding sourceEuropean Research Council (ERC) project #949850


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