The Study of Activity of the Sum of Triterpene Acids From Fruits of Sea Buckthorn and Cranberry on the Model of Chronic Inflammation

2015 ◽  
Vol 22 (2) ◽  
pp. 85-88
Author(s):  
Черников ◽  
M. Chernikov ◽  
Горбатюк ◽  
N. Gorbatyuk ◽  
Терехов ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Aqueous Suspension ◽  
Mechanisms Of Action ◽  
Primary Reaction ◽  
Experimental Conditions ◽  
Adjuvant Induced Arthritis ◽  
Triterpene Acids ◽  
The Right ◽  
New Compounds ◽  
Subplantar Injection

Mandatory stage of the study of new compounds with strong pharmacological activity is the study of possible mechanisms of action. The purpose of this study was to investigate anti-inflammatory activity the amount of triterpene acids when they are used in the medical scheme in terms of adjuvant-induced arthritis. The studies were performed on rats male Wistar weighing 210-230 gr. Model of arthritis was reproduced by subplantar injection of 0.1 ml Freind´scomplete adjuvant (Sigma, USA) into the right hind paw of rats. The researched objects (the triterpenoids buckthorn and cranberry) were administered orally once a day in the form of an aqueous suspension at a dose of 100 mg/kg of the medical scheme (for 12 days, starting 14 days after adjuvant injection). The diclofenac at a dose of 8 mg/kg was used as the comparison drug. The intensity of the inflammatory response was recorded by ecometrics data. The authors found that the introduction of diclofenac was accompanied by a decrease in the intensity of primary and secondary inflammatory response. Triterpenoids cranberry reduced the primary reaction and had a slight influence on the formation of secondary inflammation. The use of triterpenoids buckthorn in these experimental conditions had no reliably significant effect on the intensity of the inflammatory process.

scholarly journals COMPARISON OF THE SEVERITY OF INFLAMMATION IN RATS WITH A PRIMARY REACTION AND SECONDARY IMMUNOLOGICAL REACTION TO AN INJECTION OF FREUND’S COMPLETE ADJUVANT

Biomeditsina ◽  
2019 ◽  
pp. 75-87
Author(s):  
A. I. Matyushkin ◽  
E. A. Ivanova ◽  
S. V. Alekseeva ◽  
K. S. Kachalov ◽  
T. A. Voronina
Keyword(s):  
Inflammatory Response ◽  
Skin Temperature ◽  
Hematological Parameters ◽  
Control Group ◽  
Immunological Reaction ◽  
Primary Reaction ◽  
Freund’S Complete Adjuvant ◽  
Freund's Complete Adjuvant ◽  
Ankle Joints ◽  
The Right

The model of chronic immune inflammation caused by the administration of Freund’s complete adjuvant (CFA) into a hind paw of rats is used as a model of rheumatoid arthritis. Under this condition, the joints of other limbs, along with those subject to the action of CFA, are damaged. The aim of this study was to compare the severity of the inflammatory process in rats with a primary reaction (edema of the left hind paw) and a secondary immunological inflammatory response (edema of the right hind paw) towards a sub-plantar injection of CFA in the left hind paw of the experimental animals.Inflammation was induced by the sub-plantar administration of 0.1 ml of CFA into the left hind paw of outbred rats. Such indicators as the edema of the metatarsus and the ankle joints of the hind paws, the weight of the animals and the skin temperature of the paws were recorded on the 7th, 14th, 21st and 28th day of the experiment. The pain threshold was recorded using a plantar test on the 15th day. Hematological parameters were assessed on the 14th and 28th day.Both a primary reaction and a secondary immunological reaction was developed on the 7th day of the experiment in 11 out of 20 animals having received CFA, while the rest of the rats demonstrated inflammation exclusively in the left hind paw. On the 7th day of the experiment, the animals with inflammation showed a higher skin temperature in the hind paws compared to the control group. The maximum edema in the rats with a primary reaction and secondary immunological inflammatory response was recorded on the 14th day of the experiment. On the 14th day, the rats with induced inflammation showed an increase in a number of hematological parameters, with the elevation being more pronounced in the animals with generalized inflammation. As a result of inflammation, pain sensitivity increased in both groups of animals with induced inflammation. In these groups, both a decrease in the edema of the paws and the normalization of hematological parameters were observed on the 28th day of the experiment. It is concluded that the most pronounced inflammatory reaction has developed by the 14th day following CFA administration, with its intensity having reduced by the 28th day. These results might be useful when assessing the pharmacological activity of various compounds using this model. 

Dual Intentional Agency

2018 ◽  
Author(s):  
Elizabeth Schechter
Keyword(s):  
Left Hemisphere ◽  
Practical Reasoning ◽  
Right Hemisphere ◽  
Brain Surgery ◽  
Experimental Conditions ◽  
Split Brain ◽  
Intentional Agency ◽  
Intentional Agents ◽  
Experimental Findings ◽  
The Right

This chapter defends the 2-agents claim, according to which the two hemispheres of a split-brain subject are associated with distinct intentional agents. The empirical basis of this claim is that, while both hemispheres are the source or site of intentions, the capacity to integrate them in practical reasoning no longer operates interhemispherically after split-brain surgery. As a result, the right hemisphere-associated agent, R, and the left hemisphere-associated agent, L, enjoy intentional autonomy from each other. Although the positive case for the 2-agents claim is grounded mainly in experimental findings, the claim is not contradicted by what we know of split-brain subjects’ ordinary behavior, that is, the way they act outside of experimental conditions.

scholarly journals Reaktive E=C(p–p)π Systeme, XXXIV Addition von Alkoholen oder primären Aminen an Phosphaalkene F3CP=C(F)OR. Neue Trifluormethylphosphane und -phosphaalkene/Reactive E = C( p – p ) π-Systems, XXXIV Addition of Alcohols or Primary Amines to Phosphaalkenes F3CP= C(F)OR . Novel Trifluoromethylphosphanes and Phosphaalkenes

1993 ◽  
Vol 48 (1) ◽  
pp. 58-67 ◽  
Author(s):  
Joseph Grobe ◽  
Duc Le Van ◽  
Gudrun Lange
Keyword(s):  
High Resolution Mass Spectrometry ◽  
Molar Ratio ◽  
Primary Amines ◽  
The Novel ◽  
Experimental Conditions ◽  
Pull System ◽  
Fragment Ions ◽  
New Compounds ◽  
C Nmr

The course of the reactions o f fluorophosphaalkenes F3CP = C (F)OR [R = Me (1), Et (2)] with methanol or ethanol strongly depends on the experimental conditions. Thus at 70 °C a mixture of the 2-phosphapropionic acid ester F3CP (H )CO2R [R = Me (3), Et (4)] and trifluoromethylphosphane H2PCF3 is formed [molar ratio: 3 or 4 /H2 CF3 ≈1/1]. If the precursors F3CP (H )CO2R [R = Me (3), Et) are used as starting materials, the reaction with ROH under the same conditions affords 3 and 4, respectively, (90 to 95% yield) with only traces of H2PCF 3. In the presence o f iPr2NH these precursors react with R′OH to give the novel trifluoromethylphosphaalkenes F3CP = C (OR )OR [R /R′: Me/Me (6); E t/E t (7); Me/Et (8)]. With Et2NH , 3 undergoes an addition/elimination process yielding the interesting push/pull system Et2N(F)C = P-CO2Me (5). 1 and 2 react with primary amines R′NH2 (R′= tBu, Me) with stereoselective formation of the fairly labile phosphaalkenes F3CP = C(OR)NHR′ [R /R′: Me/tBu (9), Et/tBu(10), Me/Me (11)] with trans-positions for CF3 and NHR′.The new compounds 3 -11 were characterized by spectroscopic investigations (1H , 19F, 31P, 13C NMR ; IR, MS) and determination of M+ or typical fragment ions [M+ -OR ] by high resolution mass spectrometry.

scholarly journals Behavioral Triggers of Skin Conductance Responses and Their Neural Correlates in the Primate Amygdala

2009 ◽  
Vol 101 (4) ◽  
pp. 1749-1754 ◽  
Author(s):  
Christopher M. Laine ◽  
Kevin M. Spitler ◽  
Clayton P. Mosher ◽  
Katalin M. Gothard
Keyword(s):  
Skin Conductance ◽  
Single Unit ◽  
Population Level ◽  
Emotional Reaction ◽  
Neural Population ◽  
Experimental Conditions ◽  
Indirect Measure ◽  
Skin Conductance Responses ◽  
The Right ◽  
Sympathetic Arousal

The amygdala plays a crucial role in evaluating the emotional significance of stimuli and in transforming the results of this evaluation into appropriate autonomic responses. Lesion and stimulation studies suggest involvement of the amygdala in the generation of the skin conductance response (SCR), which is an indirect measure of autonomic activity that has been associated with both emotion and attention. It is unclear if this involvement marks an emotional reaction to an external stimulus or sympathetic arousal regardless of its origin. We recorded skin conductance in parallel with single-unit activity from the right amygdala of two rhesus monkeys during a rewarded image viewing task and while the monkeys sat alone in a dimly lit room, drifting in and out of sleep. In both experimental conditions, we found similar SCR-related modulation of activity at the single-unit and neural population level. This suggests that the amygdala contributes to the production or modulation of SCRs regardless of the source of sympathetic arousal.

scholarly journals A Soft Coral-Derived Compound, 11-epi-Sinulariolide Acetate Suppresses Inflammatory Response and Bone Destruction in Adjuvant-Induced Arthritis

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e62926 ◽  
Author(s):  
Yen-You Lin ◽  
Yen-Hsuan Jean ◽  
Hsin-Pai Lee ◽  
Wu-Fu Chen ◽  
Yu-Min Sun ◽  
...  
Keyword(s):  
Inflammatory Response ◽  
Soft Coral ◽  
Bone Destruction ◽  
Adjuvant Induced Arthritis

An experimental study of strongly nonlinear waves in a rotating system

1987 ◽  
Vol 177 ◽  
pp. 381-394 ◽  
Author(s):  
Dominique P. Renouard ◽  
Gabriel Chabert D'Hières ◽  
Xuizhang Zhang
Keyword(s):  
Equilibrium Shape ◽  
Scaling Law ◽  
Maximum Amplitude ◽  
Rotating Platform ◽  
Coriolis Parameter ◽  
Rotating System ◽  
Height Variation ◽  
Experimental Conditions ◽  
Strongly Nonlinear ◽  
The Right

The influence of rotation upon internal solitary waves is studied in a (10 m × 2 m × 0.6 m) channel located on the large rotating platform at Grenoble University. We observe an intumescence which moves along the right-hand side of the channel with respect to its direction of propagation. Along the side, once the intumescence reaches its equilibrium shape, the height variation of the interface with time is correctly described by the sech2 function, and the characteristic KdV scaling law linking the maximum amplitude and the wavelength along the side is fulfilled. The intumescence is a stable phenomenon which moves as a whole without deformation apart from the viscous damping. For identical experimental conditions, the amplitude of the intumescence along the side increases with increasing Coriolis parameter, and at a given period of rotation of the platform, the celerity along the side increases with increasing amplitude. But for identical conditions, we found that the celerity along the side is equal to the celerity that the wave would have for such conditions without rotation. The amplitude of the intumescence in a plane perpendicular to the wall decreases exponentially with increasing distance from the side, but the crest of the wave is curved backward.

Preparation of cationic waste paper and its application in poisonous dye removal

2013 ◽  
Vol 67 (11) ◽  
pp. 2560-2567 ◽  
Author(s):  
Fan Yang ◽  
Xiaojie Song ◽  
Lifeng Yan
Keyword(s):  
Low Cost ◽  
Aqueous Suspension ◽  
Order Kinetic ◽  
Acid Orange 7 ◽  
Anionic Dyes ◽  
Experimental Conditions ◽  
Adsorption Models ◽  
Acid Orange ◽  
Initial Ph ◽  
Pseudo Second Order

Cationic paper was prepared by reaction of paper with 2,3-epoxypropyltrimethylammonium chloride in aqueous suspension, and tested as low-cost adsorbent for wastewater treatment. The experimental results revealed that anionic dyes (Acid Orange 7, Acid Red 18, and Acid Blue 92) were adsorbed on the cationic paper nicely. The maximum amount of dye Acid Orange 7 adsorbed on cationic paper was 337.2 mg/g in experimental conditions. The effects of initial dye concentration, temperature, and initial pH of dye solution on adsorption capacity of cationic paper were studied. The pseudo-first-order and pseudo-second-order kinetic models were applied to describe the kinetic data. The Freundlich and Langmuir adsorption models were used to describe adsorption equilibrium. The thermodynamic data indicated that the adsorption process of dye on cationic paper occurred spontaneously.

scholarly journals Comparative study of inflammatory response and adhesions formation after fixation of different meshes for inguinal hernia repair in rabbits

2005 ◽  
Vol 20 (5) ◽  
pp. 347-352 ◽  
Author(s):  
Alberto Goldenberg ◽  
Jacques Matone ◽  
Wagner Marcondes ◽  
Fernando Augusto Mardiros Herbella ◽  
José Francisco de Mattos Farah
Keyword(s):  
Inflammatory Response ◽  
Abdominal Wall ◽  
Peritoneal Cavity ◽  
Abdominal Cavity ◽  
Mesh Fixation ◽  
Rabbit Model ◽  
Laparoscopic Approach ◽  
Preperitoneal Space ◽  
Similar Amount ◽  
The Right

PURPOSE: Compare, in a rabbit model, the inflammatory response and adhesions formation following surgical fixation of polypropilene and Vypro mesh in the inguinal preperitoneal space. METHODS: Fourteen male New Zealand rabbits, weighing between 2.000 to 2.500 g were used. A midline incision was made and the peritoneal cavity was exposed. The 2,0X1,0 cm polypropylene mesh was fixed in the left flank and secured to the margins with 3-0 prolene in a separate pattern. In the right flank, a 2,0X1,0 cm Vypro II mesh was sewn in the same way. After the post surgical period, the animals were again anesthetized and underwent laparoscopic approach, in order to identify and evaluate adhesions degree. Both fixed prosthesis were excised bilaterally with the abdominal wall segment, including peritoneum, aponeurosis and muscle and sent to a pathologist RESULTS: Operative time ranged from 15 to 25 minutes and no difficulties in applying the mesh were found. From the 14 polypropylene meshes fixed to the intact peritoneum, 11 had adhesions to the abdominal cavity (78,6%). Concerning Vypro mesh, 12 animals developed adhesions from the 14 with mesh fixation (85,7%). Histological examination of tissues harvested revealed fibroblasts, collagen, macrophages and lymphocytes between the threads of the mesh. CONCLUSION: Polypropylene and Vypro mesh, when implanted in the peritoneal cavity of rabbits provoke similar amount of adhesions. Vypro mesh tissues had higher fibrosis resulting in better mesh incorporation to the abdominal wall.

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