Simulation of the Evolution of Pathological Processes in Parkinson´s Disease

2015 ◽  
Vol 22 (2) ◽  
pp. 26-32
Author(s):  
Козлов ◽  
A. Kozlov ◽  
Даянова ◽  
D. Dayanova ◽  
Добрынина ◽  
...  

In medicine, there are very large numbers of models of different pathological processes. Thus, models of the evolution of pathologies, in particular, in the clinic of nervous diseases absent altogether. This work presents an example of mathematical modeling the development of pathology in the human body in the form of transition from postural tremor to periodic tremor Parkinson´s and further to a rigid form. The appearance of periodicity in the characteristics of the neuromuscular system corresponds to the pathological phenomenon, for example, Parkinson´s disease. The authors note the similarity of tapping in relatively healthy person with a tremor of a patient with Parkinson´s disease from the position of the phase portraits. At high excitations from the striatum in patients with Parkinson´s disease (in models is Ш=410 u.e.) in the cluster of the neuromuscular system comes rigid phase and in the effector system there is a severe form of parkinsonism, the muscles can no longer perform any movements. In this case the timebase activity of effector organs moves in a steady mode and takes some constant value. The simulation results suggest the high consistency of the obtained results with real signals recorded by the subjects in different conditions. For various indicators of the functional systems of the human body, it is necessary to find the coefficients b and ud directionally.

2021 ◽  
Vol 04 (11) ◽  
pp. 114-119
Author(s):  
Akanksha Gangwar

With increasing globalization and industrialization, the life of human beings hasbecome much more sedentary, technology dependent and full of rush and hustle because of which humans are gradually becoming unhealthier and more diseased than ever before. Today, everyone is in hurry so they want everything to be quick and speedy. They don’t have time to spend upon thinking about eating healthy and lead a healthy lifestyle; which eventually made them fell ill and get various kinds of diseases. Vyadhikshamatwais a simple term which means body’s own capacity to resist various kind of diseases. It is related to balaas well as ojasas mentioned in ayurveda. Balais characteristic feature of healthy physical and mental state of body. As the aim of ayurveda is to make an unhealthy person disease free and to maintain the health of a healthy person. So, by choosing a healthy diet and lifestyle one can not only become disease free but can also lead a long and healthy life as well. Various bala, ojasand vyadhikshamatwapromoting factors are mentioned in Ayurvedic texts which acts directly or indirectly upon human body. This article is the compilation of bala, ojasand vyadhikshamatwapromoting factors


10.12737/6718 ◽  
2014 ◽  
Vol 3 (3) ◽  
pp. 4-17
Author(s):  
Болотов ◽  
S. Bolotov ◽  
Пахомов ◽  
A. Pakhomov ◽  
Козлова ◽  
...  

The paper presents results of neuromuscular system indices in male and female subjects aged between 20 and 28 who have been living in the North over 15 years and have different experience of applying cold procedures. Mean age of subjects is 22.8 years. Hand tremor parameters were recorded before and after local chilling procedure, on this basis body reaction in all experimental groups was compared. The control group is composed of participants who do not receive the experimental treatment. Group 1 composes of subjects who take chilling procedures less than 1 year. Group 2 composes of subjects who take chilling procedures more than 2 years. The effect of local chilling of changing neuromuscular system indices (tremorograms) is compared in 3 experimental groups in different seasons. During the experiment the statistical processing of obtained data is carried out, quasi-attractors squares are calculated for all experimental groups, phase portraits of tremor dynamics are created. Thus, order parameters in description of neuromuscular system under local chilling are identified.


1972 ◽  
Vol 3 (1) ◽  
pp. 71-76 ◽  
Author(s):  
Albert Damon ◽  
Carl C. Seltzer

The notion that human body form and function are related is strong in folklore and literature, and in medicine dates back at least to Hippocrates. The Normative Aging Study is in a position to test this belief among large numbers of healthy subjects followed over their adult lifetimes. The goals, procedures, and early findings of the morphologic aspect of the Normative Aging Study are presented in this article.


2013 ◽  
Vol 333-335 ◽  
pp. 675-679
Author(s):  
Yan Tao Zhao ◽  
Bo Zhang ◽  
Xu Guang Zhang ◽  
Xiao Li Li ◽  
Mei Ling Fu ◽  
...  

This paper presents an efficient and novel framework for human action recognition based on representing the motion of human body-joints and the theory of nonlinear dynamical systems. Our work is motivated by the pictorial structures model and advances in human pose estimation. Intuitively, a collective understanding of human joints movements can lead to a better representation and understanding of any human action through quantization in the polar space. We use time-delay embedding on the time series resulting of the evolution of human body-joints variables along time to reconstruct phase portraits. Moreover, we train SVM models for action recognition by comparing the distances between trajectories of human body-joints variables within the reconstructed phase portraits. The proposed framework is evaluated on MSR-Action3D dataset and results compared against several state-of-the-art methods.


2019 ◽  
Vol 6 (1) ◽  
pp. 28-32
Author(s):  
Ramin Shahbad ◽  
Mohsen Mortazavi ◽  
Fereshteh Alizadeh-Fard ◽  
Zeinab Mohammadi ◽  
Fatemeh Alavi ◽  
...  

Objective: Femur is the strongest, longest and heaviest bone in the human body. Due to the great importance of femur in human body, its injury may cause large numbers of disabilities and mortality. Considering various effective parameters such as mechanical properties, geometry, loading configuration, etc. can propel the study to the trustable results. Methods: A 3D finite element model of the femur was subjected to different impact loading and orientations and also material properties. In addition to a reference healthy model of analysis, a total of 14 cases including four different loading conditions, six different bone density conditions and four different load orientations were considered. Results: Findings showed that the models with higher bone density cannot considerably reduce the stress under the impact loadings but porous models receive high mechanical stress which the bone prone to injury. The stress and displacement of the bone model received more values distributed through the femoral neck. Conclusion: Porous bone models had greater stress values under an impact load. Higher and faster impacts may create multi-fracture breaks of the femur. The inferior femoral neck regions are the most vulnerable part in response to the impacts.


1963 ◽  
Vol 18 (6) ◽  
pp. 1285-1288 ◽  
Author(s):  
E. C. Halliday ◽  
T. J. Hugo

A description is given of an instrument which measures the radiation area of the human body. An isotropic flux of light is produced in a large integrating vessel and when a human subject whose skin has been suitably blackened enters the vessel, the light intensity at a window in the wall of the vessel is decreased. A photometric measurement of this decrease enables the effective area of the surface of the skin of the subject to be measured with an accuracy of better than 1%. The instrument enables measurements to be made on large numbers of subjects rapidly and reliably. human body surface; radiation area; photometric measurement Submitted on April 5, 1963


Author(s):  
Namrata P. Gharge ◽  
Ranjitha Naik

Ayurveda is a system of medicine with historical roots in the Indian subcontinent. The main aim of Ayurveda is maintenance of health of a healthy person and to treat the disease. Various fervent concepts with sturdy bed rocks are led down for understanding the human body. Discrete postulates and system in disclosing the gear of the disease in various Ayurveda classics. One of the ultimate and tempting picture is Leena Dosha in fine tune of the disease. During the pathogenesis of the disease the Dosha will undergo various Avastha one such important Avastha is Leena Dosha Avastha which is mostly considered as latent phase of the disease, if the physician understand the concept of Leena Dosha Avastha physician can easily subsides the disease by the proper plan of treatment. As in India many top killer diseases had been short listed among them quite common is Malaria. So in this article an attempt had been made to understand the Leena Dosha Avastha w.s.r to Latent phase.


2020 ◽  
Vol 8 (8) ◽  
pp. 4144-4150
Author(s):  
Ripsa Raj K. P ◽  
P Sudhakar Reddy

Beauty is the desire of every individual to give pleasure to the sense.The Federal Food, Drug, and Cosmetic Act (FD&C Act) defines cosmetics by their intended use, as "articles intended to be rubbed, poured, sprin-kled, or sprayed on, introduced into, or otherwise applied to the human body for cleansing, beautifying, promoting attractiveness, or altering the appearance". Under this law cosmetics must not adulterate or mis-branded. The cosmetic preparations are used for worship and for sensual enjoyment in India since Vedic period. The cleansing, beautifying and attractiveness effects are described in Ayurveda extensively. Swasthavritta, the preventive principles of Ayurveda laid down rules and regulations like Dinacharya (Dai-ly routine), Ritu chary (Seasonal regimen), Sadvritta (Good conducts of life) etc, to be followed by a healthy person. Among these the practices of daily routines are very much relevant in promoting cosmetic effect which is reviewed in this article.


2013 ◽  
Vol 7 (1) ◽  
pp. 20-24 ◽  
Author(s):  
Chandra Mani Adhikari ◽  
R Rajbhandari ◽  
YR Limbu ◽  
R Malla ◽  
R Sharma ◽  
...  

Coronary artery disease (CAD), predominately manifest in older individuals, is a devastating dis­ease precisely because an otherwise healthy person in the prime of life may die or become disabled without warning. When the afflicted individual is under the age of 40, the tragic consequences for family, friends, and occupation are particularly catastrophic and unexpected. Fortunately, the incidence of myocardial infarction (MI) and symptomatic CAD in young adults is low; most stud­ies show that only about 3% of all CAD cases occur in this age range. Premature CAD is defined as cardiac events occurring before the age of 45 in men and 55 in women. In its severe form it is defined as CAD occurring below the age of 40 years. Prematurity and severity suggests that the dis­ease starts at an early age and has a malignant course. In this study, we aim to investigate the major risk factor (smoking, Hypertension, Diabetes and dyslipidemia ) as defined by ACC-AHA pattern in ACS patient 40years or below admitted in Shahid Gangalal National Heart Centre (SGNHC) from April 2008 to April 2009. There were all together 54 ACS patients, male 44(81%) and female 10(19%). HTN is the risk factor which was more commonly diagnosed and treated, while Dys­lipidemia, DM and IFG were not usually diagnosed in young patient before they were diagnosed CAD. Dyslipidemia was the most common comprising 83.3% followed by HTN 70%, smoking 70%, abnormal blood glucose level 50%, DM in 22.2% while IFG in 27.7 %. High total cholesterol (48%) is the common form of dyslipidemia followed by high LDL (44.4%), low HDL in 31.4%. When non modifiable risk factor family history is excluded, 85% of the patients have two or more risk factors of CAD. When smoking along with family history is excluded 94.5% of the patients have 1 or more risks factors for CAD. Nepalese Heart Journal | Volume 7 | No.1 | November 2010 (special issue) | Page 20-24 DOI: http://dx.doi.org/10.3126/njh.v7i1.8497


Author(s):  
Shulin Wen ◽  
Jingwei Feng ◽  
A. Krajewski ◽  
A. Ravaglioli

Hydroxyapatite bioceramics has attracted many material scientists as it is the main constituent of the bone and the teeth in human body. The synthesis of the bioceramics has been performed for years. Nowadays, the synthetic work is not only focused on the hydroapatite but also on the fluorapatite and chlorapatite bioceramics since later materials have also biological compatibility with human tissues; and they may also be very promising for clinic purpose. However, in comparison of the synthetic bioceramics with natural one on microstructure, a great differences were observed according to our previous results. We have investigated these differences further in this work since they are very important to appraise the synthetic bioceramics for their clinic application.The synthetic hydroxyapatite and chlorapatite were prepared according to A. Krajewski and A. Ravaglioli and their recent work. The briquettes from different hydroxyapatite or chlorapatite powders were fired in a laboratory furnace at the temperature of 900-1300°C. The samples of human enamel selected for the comparison with synthetic bioceramics were from Chinese adult teeth.


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