The molecular and genetic basis of carcinogenesis
The textbook deals with the classification of tumor growth, signs of malignancy, genetic basis of cancer, chronology of cellular events of oncogenesis. The differences between oncogenes and suppressor genes by the principle of action, the role of apoptosis in the processes of programmed cell death and their utilization are discussed. Attention is paid to the role of apoptosis defects in the development of oncogenic States. The modern ideas about the diagnosis of oncological diseases, which include screening examinations and individual verification of the tumor type, are generalized. The modern successes of diagnostic techniques, which were the result of the combined capabilities of molecular genetics and cytogenetics, are noted. The features of the course of virus-induced and non-viral forms of cancer are analyzed. Fundamental and clinical aspects of Oncology are combined. Meets the requirements of the Federal state educational standards of higher education of the last generation. For students on programs of specialization "Medical business", "Pediatrics", "Medical biochemistry". It will also be useful for residents and doctors.