scholarly journals Presence of Phytol, a Precursor of Vitamin E in Chaetomorpha Antinnina

2013 ◽  
Vol 12 (2) ◽  
pp. 57-65 ◽  
Author(s):  
K Byju ◽  
G Vasundhara ◽  
V Anuradha ◽  
S M Nair ◽  
N C Kumar
Keyword(s):  
Mass Spectrum ◽  
Vitamin E ◽  
Molecular Mass ◽  
Green Algae ◽  
Isomeric Form ◽  
Molecular Formula ◽  
Vitamin K1 ◽  
Base Peak ◽  
Anticancer Activities ◽  
Diterpene Alcohol

Phytol, a precursor of vitamin E was identified from green algae Chaetomorpha antinnina collected from Chullickal, Kochi Kerala coast, using GC-MS. Phytol is an acyclic diterpene alcohol that can be used as a precursor for the manufacture of synthetic forms of vitamin E and vitamin K1. The compound 3,7,11,15-tetramethylhexadec-2-en-1-ol also known as phytol  which exist  naturally only in single isomeric form having molecular formula C20H40O and molecular mass 296. From the total ion chromatogram more than twenty peaks were observed, the mass spectrum of the peak at Rt 21.53 was resolved and the major fragmentations were noted. Major fragmentation were m/z 71 the base peak, m/z 296 the molecular ion peak, m/z 43, m/z 57, m/z 81, m/z 95, and m/z 123. It was found that there are some other compounds apart from this identified phytol which are more complicated in structure and cannot be characterised using GC-MS. Phytol is reported to have both antimicrobial and anticancer activities. The green algae Chaetomorpha antinnina can be proposed to be a good natural source for production of phytol.

scholarly journals Synthesis, DFT Calculations, Antiproliferative, Bactericidal Activity and Molecular Docking of Novel Mixed-Ligand Salen/8-Hydroxyquinoline Metal Complexes

Molecules ◽  
2021 ◽  
Vol 26 (16) ◽  
pp. 4725
Author(s):  
Badriah Saad Al-Farhan ◽  
Maram T. Basha ◽  
Laila H. Abdel Rahman ◽  
Ahmed M. M. El-Saghier ◽  
Doaa Abou El-Ezz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Molecular Docking ◽  
Metal Complexes ◽  
Wide Spectrum ◽  
Mixed Ligand ◽  
Molecular Formula ◽  
Hep G2 ◽  
Anticancer Activities ◽  
Azomethine Group ◽  
Ic50 Values

Despite the common use of salens and hydroxyquinolines as therapeutic and bioactive agents, their metal complexes are still under development. Here, we report the synthesis of novel mixed-ligand metal complexes (MSQ) comprising salen (S), derived from (2,2′-{1,2-ethanediylbis[nitrilo(E) methylylidene]}diphenol, and 8-hydroxyquinoline (Q) with Co(II), Ni(II), Cd(II), Al(III), and La(III). The structures and properties of these MSQ metal complexes were investigated using molar conductivity, melting point, FTIR, 1H NMR, 13C NMR, UV–VIS, mass spectra, and thermal analysis. Quantum calculation, analytical, and experimental measurements seem to suggest the proposed structure of the compounds and its uncommon monobasic tridentate binding mode of salen via phenolic oxygen, azomethine group, and the NH group. The general molecular formula of MSQ metal complexes is [M(S)(Q)(H2O)] for M (II) = Co, Ni, and Cd or [M(S)(Q)(Cl)] and [M(S)(Q)(H2O)]Cl for M(III) = La and Al, respectively. Importantly, all prepared metal complexes were evaluated for their antimicrobial and anticancer activities. The metal complexes exhibited high cytotoxic potency against human breast cancer (MDA-MB231) and liver cancer (Hep-G2) cell lines. Among all MSQ metal complexes, CoSQ and LaSQ produced IC50 values (1.49 and 1.95 µM, respectively) that were comparable to that of cisplatin (1.55 µM) against Hep-G2 cells, whereas CdSQ and LaSQ had best potency against MDA-MB231 with IC50 values of 1.95 and 1.43 µM, respectively. Furthermore, the metal complexes exhibited significant antimicrobial activities against a wide spectrum of both Gram-positive and -negative bacterial and fungal strains. The antibacterial and antifungal efficacies for the MSQ metal complexes, the free S and Q ligands, and the standard drugs gentamycin and ketoconazole decreased in the order AlSQ > LaSQ > CdSQ > gentamycin > NiSQ > CoSQ > Q > S for antibacterial activity, and for antifungal activity followed the trend of LaSQ > AlSQ > CdSQ > ketoconazole > NiSQ > CoSQ > Q > S. Molecular docking studies were performed to investigate the binding of the synthesized compounds with breast cancer oxidoreductase (PDB ID: 3HB5). According to the data obtained, the most probable coordination geometry is octahedral for all the metal complexes. The molecular and electronic structures of the metal complexes were optimized theoretically, and their quantum chemical parameters were calculated. PXRD results for the Cd(II) and La(III) metal complexes indicated that they were crystalline in nature.

Simultaneous liquid-chromatographic determination of vitamin K1 and vitamin E in serum.

1989 ◽  
Vol 35 (12) ◽  
pp. 2285-2289 ◽  
Author(s):  
B E Cham ◽  
H P Roeser ◽  
T W Kamst
Keyword(s):  
Vitamin E ◽  
Human Serum ◽  
High Performance ◽  
Chromatographic Determination ◽  
High Performance Liquid Chromatographic ◽  
Tocopheryl Acetate ◽  
Vitamin K1 ◽  
Chromatographic Procedure ◽  
Liquid Chromatographic Determination ◽  
Liquid Chromatographic

Abstract We describe a high-performance liquid chromatographic procedure for the simultaneous measurement of vitamins K1 and E in human serum. Delipidated human serum (free of vitamins K1 and E) was used to make standard solutions of these vitamins, and cetyl naphthoate and alpha-tocopheryl acetate were the internal standards for vitamin K1 and vitamin E, respectively. A simple, novel separation method utilizing liquid-liquid partition chromatography was used as a preparative "clean-up" procedure. Cetyl naphthoate and vitamin K1 (after post-column reduction) were detected by fluorescence, alpha-tocopheryl acetate and vitamin E by ultraviolet absorption. Sensitivity (detection limit) of the assay was 30 pg for vitamin K1 and 5 ng for vitamin E per injection. The method is specific, precise, and more rapid than previously described procedures. Within- and between-assay CVs were 8.1% and 12.9%, respectively, for vitamin K1; 3.5% and 6.0%, respectively, for vitamin E. Analytical recoveries of vitamins K1 and E were 80% and 93%, respectively, from serum and from delipidated serum (standards). The average neonatal serum concentration of vitamin K1 was 83 ng/L, 2.5 mg/L for vitamin E; for normolipidemic adults, the values were 343 ng/L and 7.9 mg/L, respectively, and for hyperlipidemic adults, 541 ng/L and 11.1 mg/L, respectively.

scholarly journals Integrated global analysis reveals a vitamin E-vitamin K1 sub-network, downstream of COLD1, underlying rice chilling tolerance divergence

Cell Reports ◽  
2021 ◽  
Vol 36 (3) ◽  
pp. 109397
Author(s):  
Wei Luo ◽  
Qing Huan ◽  
Yunyuan Xu ◽  
Wenfeng Qian ◽  
Kang Chong ◽  
...  
Keyword(s):  
Vitamin E ◽  
Global Analysis ◽  
Chilling Tolerance ◽  
Vitamin K1

V

2020 ◽  
pp. 813-843
Author(s):  
Sean Ainsworth
Keyword(s):  
Vitamin D ◽  
Vitamin E ◽  
Adverse Effects ◽  
Vitamin A ◽  
Vitamin B12 ◽  
Alpha Tocopherol ◽  
Vitamin K1 ◽  
Varicella Zoster ◽  
Maternal Treatment

This chapter presents information on neonatal drugs that begin with V, including use, pharmacology, adverse effects, fetal and infant implications of maternal treatment, treatment, and supply of Vancomycin, Varicella-zoster immunoglobulin and vaccine, Vasopressin, desmopressin, and terlipressin, Vigabatrin, Vitamin A (retinol), Vitamin B12 (hydroxocobalamin), Vitamin D (special formulations), Vitamin D (standard formulations), Vitamin E (alpha tocopherol), Vitamin K1 = phytomenadione (rINN), phytonadione (USAP), and Vitamins (multi-vitamins)

scholarly journals Determination of Key Metabolites during Biodegradation of Hexahydro-1,3,5-Trinitro-1,3,5-Triazine with Rhodococcus sp. Strain DN22

2002 ◽  
Vol 68 (1) ◽  
pp. 166-172 ◽  
Author(s):  
Diane Fournier ◽  
Annamaria Halasz ◽  
Jim Spain ◽  
Petr Fiurasek ◽  
Jalal Hawari
Keyword(s):  
Molecular Mass ◽  
Degradation Products ◽  
Degradation Pathway ◽  
Aerobic Biodegradation ◽  
Ring Cleavage ◽  
Molecular Formula ◽  
Dead End ◽  
Liquid Chromatographic ◽  
Chromatographic Mass

ABSTRACT Rhodococcus sp. strain DN22 can convert hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) to nitrite, but information on degradation products or the fate of carbon is not known. The present study describes aerobic biodegradation of RDX (175 μM) when used as an N source for strain DN22. RDX was converted to nitrite (NO2 −) (30%), nitrous oxide (N2O) (3.2%), ammonia (10%), and formaldehyde (HCHO) (27%), which later converted to carbon dioxide. In experiments with ring-labeled [15N]-RDX, gas chromatographic/mass spectrophotometric (GC/MS) analysis revealed N2O with two molecular mass ions: one at 44 Da, corresponding to 14N14NO, and the second at 45 Da, corresponding to 15N14NO. The nonlabeled N2O could be formed only from -NO2, whereas the 15N-labeled one was presumed to originate from a nitramine group (15N-14NO2) in RDX. Liquid chromatographic (LC)-MS electrospray analyses indicated the formation of a dead end product with a deprotonated molecular mass ion [M-H] at 118 Da. High-resolution MS indicated a molecular formula of C2H5N3O3. When the experiment was repeated with ring-labeled [15N]-RDX, the [M-H] appeared at 120 Da, indicating that two of the three N atoms in the metabolite originated from the ring in RDX. When [U-14C]-RDX was used in the experiment, 64% of the original radioactivity in RDX incorporated into the metabolite with a molecular weight (MW) of 119 (high-pressure LC/radioactivity) and 30% in 14CO2 (mineralization) after 4 days of incubation, suggesting that one of the carbon atoms in RDX was converted to CO2 and the other two were incorporated in the ring cleavage product with an MW of 119. Based on the above stoichiometry, we propose a degradation pathway for RDX based on initial denitration followed by ring cleavage to formaldehyde and the dead end product with an MW of 119.

Spectres de masse d'hydrazino-2 benzo- et naphtothiazoles et d'hydrazones des méthyl-3 benzo- et naphtothiazolinones-2

1975 ◽  
Vol 53 (23) ◽  
pp. 3677-3680 ◽  
Author(s):  
Jean-Claude Richer ◽  
Philippe Lapointe ◽  
Martine Beljean ◽  
Michel Pays
Keyword(s):  
Mass Spectrum ◽  
Mass Spectra ◽  
Base Peak ◽  
Molecular Ion ◽  
Ion Fragmentation ◽  
Fragment Ions ◽  
Sampling Probe ◽  
Electron Impact Mass ◽  
Impact Mass ◽  
Hydrazone Form

Electron impact mass spectra are reported for the hydrazones of 3-methyl-2-benzothiazolinone (1), of 4-, 5-, 6-, and 7-chloro-3-methylbenzo-2-thiazolinones (2, 3, 4, and 5) and of 3-methyl-naphtho[2,1-d]-2-thiazolinone (6), as well as for 2-hydrazinobenzothiazole (7), for 4-, 5-, 6-, and 7-chloro-2-hydrazinobenzothiazoles (8, 9, 10, and 11) and for 2-hydrazinonaphtho[2,1-d]thiazole (12). The results obtained in the two series are compared. The 2-hydrazone and 3-methyl-benzo-2-thiazolinone and its derivatives all form a base peak corresponding to the molecular ion; fragmentation proceeds mainly by successive losses of·NH2, HCN, HCN, and then CS. Initial losses of N2H2, NH·, and NH3 are minor fragmentation routes.In the case of 2-hydrazinobenzothiazole and its derivatives, the base peak is still that of the molecular ion; however, the relative proportions of the various fragment ions vary with the position of sampling probe inside the apparatus. Thus it is concluded that the observed mass spectrum is that of a mixture of the possible hydrazone-hydrazine tautomers. The principal fragmentations involve the initial loss of NH3 (leading to a stabilized ion), of NH2· (probably from the hydrazone form), and of N2H2.(Journal Translation)

scholarly journals Novel Phytochemical Constituents Identified from the Seeds of Mesua Ferrea L and their Anticancer Activity

2017 ◽  
pp. 1-4
Author(s):  
Faizan ◽  
Mehta ◽  
Yasir ◽  
Masood
Keyword(s):  
Mass Spectrum ◽  
Chemical Analysis ◽  
Nmr Spectra ◽  
Phenyl Acetate ◽  
13C Nmr Spectra ◽  
Anticancer Activities ◽  
Variable Activity ◽  
Phytochemical Constituents ◽  
New Compounds ◽  
First Time

Novel phytochemical constituents were isolated from the hexane extract of Mesua Ferrea L. seeds by using n-hexane. The two new compounds were identified by spectral (IR, 1H NMR, 13C NMR spectra, mass spectrum, elemental analysis) and chemical analysis. The compounds identified are 5-formyl-2-(propan-2-yl) phenyl acetate and 2, 4-diformyl-6-(propan-2-yl) phenyl acetate. Anticancer activities were assessed for the isolated compounds and have shown variable activity. These novel compounds are being reported for the first time.

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