scholarly journals Treatment Strategy for Standard-Dose Proton Pump Inhibitor-Resistant Reflux Esophagitis

2017 ◽  
Vol 84 (5) ◽  
pp. 209-214 ◽  
Author(s):  
Katsuhiko Iwakiri
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Esophagitis ◽  
Treatment Strategy ◽  
Standard Dose

scholarly journals High proton pump inhibitor exposure increases risk of calcinosis in systemic sclerosis

Rheumatology ◽  
2020 ◽  
Author(s):  
Lauren V Host ◽  
Corrado Campochiaro ◽  
Ana Afonso ◽  
Svetlana I Nihtyanova ◽  
Christopher P Denton ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Odds Ratio ◽  
Disease Duration ◽  
Standard Dose ◽  
Clinical Impact ◽  
Retrospective Data ◽  
Single Centre ◽  
High Proton ◽  
High Doses

Abstract Objective To investigate the association between proton pump inhibitor (PPI) use and the presence and severity of calcinosis in SSc. Methods We analysed data from two SSc cohorts from a single centre. Cohort 1 included 199 patients reviewed over 10 years, for whom retrospective data on PPI use and calcinosis were available. Cohort 2 was recruited prospectively and included 215 consecutive patients, who underwent clinical assessment. Outcomes of interest were presence of current calcinosis (CC) or calcinosis at any time (CAT). Results The cohort 1 data analysis showed that among patients on standard dose PPI 20% had calcinosis, while in those on high doses of PPI calcinosis was present in 39% (P = 0.003). Analysis of the data from cohort 2 confirmed these findings, demonstrating that the odds of CAT increased significantly with longer PPI exposure [odds ratio (OR) 1.04, 95% CI: 1.02, 1.06; P < 0.001], longer disease duration (OR 1.08, 95% CI: 1.05, 1.12; P < 0.001) and greater age (OR 1.03, CI: 1.01, 1.05; P = 0.010). Multivariable logistic regression showed that higher exposure to PPI remained a significant predictor of calcinosis, with PPI exposure >10 years increasing the risk of CAT >6-fold, compared with no PPI (OR 6.37, 95% CI: 1.92, 21.17; P = 0.003) after adjusting for disease duration and antibodies. Conclusion We confirm a significant association between high PPI exposure with severity of calcinosis in SSc. Given the clinical impact of calcinosis and reflux in SSc, PPI exposure as a potentially modifiable risk factor for calcinosis requires further evaluation.

scholarly journals The Predictive Factors of Responsiveness to Proton Pump Inhibitor Therapy for Eosinophilic Esophagitis

2019 ◽  
Vol 1 (1) ◽  
pp. 220-230
Author(s):  
Atsushi Hashimoto ◽  
Takashi Sugawa ◽  
Narika Iwakura ◽  
Risa Uemura ◽  
Akinari Sawada ◽  
...  
Keyword(s):  
Multivariate Analysis ◽  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Predictive Factors ◽  
Eosinophilic Esophagitis ◽  
Reflux Esophagitis ◽  
Odds Ratio ◽  
Proton Pump Inhibitor Therapy ◽  
High Power Field ◽  
Factors Associated

Approximately half of patients with eosinophilic esophagitis (EoE) respond clinically and histologically to proton pump inhibitor (PPI) therapy. Although recent guidelines suggest that PPI-responders and non-responders were included in EoE, it is important to investigate the predictive factors of PPI- responsiveness. This study aimed to determine the rate of PPI- responders and compare the characteristics of PPI-responders and non-responders. Fifty-nine patients with esophageal eosinophilia received PPI therapy for eight weeks, and its efficacy was assessed. PPI- responsiveness was diagnosed based on the relief in symptoms and reduction of intraepithelial eosinophilic infiltration to <15 per high-power field (hpf) after PPI therapy. Multivariate analysis was performed to identify factors associated with PPI-responders. Of the 59 patients, 41 (69.5%) were diagnosed with PPI-responders. The rate of gastrointestinal (GI) screening in the indications for endoscopy was significantly higher in patients with PPI- responders than in those with non-responders. On multivariate analysis, GI screening and presence of reflux esophagitis was associated with an increased odds ratio (OR) of PPI-responders, but presence of rings with a decreased OR of PPI-responders. Presence of reflux esophagitis and absence of rings on endoscopy especially during GI screening might be significant predictive factors for PPI response in patients with EoE.

scholarly journals Evaluation of symptomatic reflux esophagitis in proton pump inhibitor users

2019 ◽  
Author(s):  
Daisuke Asaoka ◽  
Tsutomu Takeda ◽  
Hitoshi Sasaki ◽  
Yuji Shimada ◽  
Kenshi Matsumoto ◽  
...  
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Esophagitis ◽  
Symptomatic Reflux

M1927 Investigation On Daily Onset of Proton Pump Inhibitor On Reflux Esophagitis and Non-Erosive Reflux Disease

2009 ◽  
Vol 136 (5) ◽  
pp. A-447
Author(s):  
Hiroshi Shida ◽  
Yuzo Sakai ◽  
Hiroyuki Hamada ◽  
Tetsuo Takayama
Keyword(s):  
Proton Pump Inhibitor ◽  
Proton Pump ◽  
Reflux Esophagitis ◽  
Reflux Disease
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