scholarly journals Factors Associated with High-sensitivity Cardiac Troponin T in Patients with Type 2 Diabetes Mellitus

2015 ◽  
Vol 82 (6) ◽  
pp. 274-280 ◽  
Author(s):  
Takashi Hitsumoto
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiac Troponin ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Troponin T ◽  
Factors Associated

scholarly journals Determinants and prognostic implications of Cardiac Troponin T measured by a sensitive assay in Type 2 Diabetes Mellitus

2010 ◽  
Vol 9 (1) ◽  
pp. 52 ◽  
Author(s):  
Jonas Hallén ◽  
Odd Johansen ◽  
Kåre I Birkeland ◽  
Lars Gullestad ◽  
Svend Aakhus ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiac Troponin ◽  
Troponin T ◽  
Cardiac Troponin T ◽  
Sensitive Assay ◽  
Prognostic Implications

scholarly journals Cardiovascular Biomarkers and Heart Failure Risk in Stable Patients With Atherothrombotic Disease: A Nested Biomarker Study From TRA 2°P‐TIMI 50

2021 ◽  
Author(s):  
David D. Berg ◽  
Benjamin L. Freedman ◽  
Marc P. Bonaca ◽  
Petr Jarolim ◽  
Benjamin M. Scirica ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Cardiac Troponin ◽  
Troponin I ◽  
High Sensitivity ◽  
Cardiac Troponin I ◽  
Atherothrombotic Disease ◽  
Risk Predictors

Background Patients with stable atherothrombotic disease vary in their risk of developing heart failure (HF). Circulating cardiovascular biomarkers may improve HF risk assessment and identify patients who may benefit from emerging HF preventive therapies. Methods and Results We measured high‐sensitivity cardiac troponin I and BNP (B‐type natriuretic peptide) in 15 833 patients with prior myocardial infarction, ischemic stroke, or peripheral artery disease from the TRA 2°P‐TIMI 50 (Thrombin Receptor Antagonist in Secondary Prevention of Atherothrombotic Ischemic Events‐Thrombolysis in Myocardial Infarction 50) trial, excluding patients with recent myocardial infarction (<30 days). Biomarkers were categorized using a priori cut points. Hospitalization for HF (HHF) end points were adjudicated with blinded structured review of serious adverse events. Associations between biomarkers and HHF outcomes were adjusted for sex and independent clinical risk predictors of HHF in our cohort (age ≥75, prior HF, type 2 diabetes mellitus, polyvascular disease, body mass index, anemia, chronic kidney disease, hypertension). Baseline high‐sensitivity cardiac troponin I and BNP each identified a significant graded risk of HHF independent of clinical risk predictors, including in the subgroups of patients with and without type 2 diabetes mellitus and with and without prior HF. Patients with both high‐sensitivity cardiac troponin I ≥5 ng/L and BNP ≥100 pg/mL had the highest HHF event rates. When added to a multivariable Cox regression model with clinical risk predictors (C‐index 0.88; 95% CI, 0.85–0.90), BNP (C ‐index 0.92; 95% CI, 0.90–0.93), and high‐sensitivity cardiac troponin I (C‐index 0.90; 95% CI, 0.88–0.92) each significantly improved the prognostic performance of the model (both P LRT <0.001). Conclusions Biomarkers of myocardial injury and hemodynamic stress are independent predictors of HHF risk in patients with stable atherothrombotic disease, with and without prior HF and/or type 2 diabetes mellitus. Registration URL: https://www.clinicaltrials.gov ; Unique identifier: NCT00526474.

258-OR: Use of High Sensitivity Cardiac Troponin T and I for Risk Classification in Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 258-OR
Author(s):  
OLIVE TANG ◽  
KUNIHIRO MATSUSHITA ◽  
JOSEF CORESH ◽  
BILL MCEVOY ◽  
A. RICHEY SHARRETT ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiac Troponin ◽  
Troponin T ◽  
High Sensitivity ◽  
Risk Classification ◽  
Cardiac Troponin T

Use of a new high-sensitivity assay for cardiac troponin T to stratify the risk of cardiovascular disease in outpatients with type-2 diabetes

2011 ◽  
Vol 3 (1) ◽  
pp. 29-36 ◽  
Author(s):  
Shogo Asano ◽  
Atsushi Suzuki ◽  
Junnichi Ishii ◽  
Sahoko Sekiguchi-Ueda ◽  
Megumi Shibata ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Cardiac Troponin ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Troponin T
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