scholarly journals Detection of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice Using USPIO-Enhanced Magnetic Resonance Imaging

2011 ◽  
Vol 78 (3) ◽  
pp. 136-137 ◽  
Author(s):  
Mika Murabayashi ◽  
Taku Sugita ◽  
Keiko Hirakawa ◽  
Hideto Kuribayashi ◽  
Ikuo Mori ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Apolipoprotein E ◽  
Knockout Mice ◽  
Resonance Imaging ◽  
Atherosclerotic Lesions ◽  
Apolipoprotein E Knockout Mice

Rabbit models of intracranial atherosclerotic disease for pathological validation of vessel wall MRI

2020 ◽  
pp. 197140092098015
Author(s):  
J Scott McNally ◽  
Adam de Havenon ◽  
Seong-Eun Kim ◽  
Chuanzhuo Wang ◽  
Shuping Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
New Zealand ◽  
Magnetic Resonance ◽  
Apolipoprotein E ◽  
Sensitivity And Specificity ◽  
Vessel Wall ◽  
Atherosclerotic Disease ◽  
Resonance Imaging ◽  
Intracranial Atherosclerotic Disease ◽  
Human Pathology

Introduction Vessel wall magnetic resonance imaging can improve the evaluation of intracranial atherosclerotic disease. However, pathological validation is needed to improve vessel wall magnetic resonance imaging techniques. Human pathology samples are not practical for such analysis, so an animal model is therefore needed. Materials and methods Watanabe heritable hyperlipidemic rabbits and apolipoprotein E knockout rabbits were evaluated against New Zealand white wild-type rabbits. Evaluation of intracranial arteries was performed with vessel wall magnetic resonance imaging and pathological analysis, rating the presence and severity of disease in each segment. Two-tailed t-tests were performed to compare disease occurrence and severity prevalence among rabbit subtypes. Sensitivity and specificity were calculated to assess the diagnostic accuracy of vessel wall magnetic resonance imaging. Results Seventeen rabbits (five Watanabe heritable hyperlipidemic, four apolipoprotein E knockout and eight New Zealand white) were analysed for a total of 51 artery segments. Eleven segments (five Watanabe heritable hyperlipidemic and six apolipoprotein E knockout) demonstrated intracranial atherosclerotic disease on pathology. Disease model animals had lesions more frequently than New Zealand white animals ( P<0.001). The sensitivity and specificity of vessel wall magnetic resonance imaging for the detection of intracranial atherosclerotic disease were 68.8% and 95.2%, respectively. When excluding mild cases to assess vessel wall magnetic resonance imaging accuracy for detecting moderate to severe intracranial atherosclerotic disease lesions, sensitivity improved to 100% with unchanged specificity. Conclusion Intracranial atherosclerotic disease can be reliably produced and detected using 3T vessel wall magnetic resonance imaging-compatible Watanabe heritable hyperlipidemic and ApoE rabbit models. Further analysis is needed to characterize better the development and progression of the disease to correlate tissue-validated animal findings with those in human vessel wall magnetic resonance imaging studies.

scholarly journals Native incretins prevent the development of atherosclerotic lesions in apolipoprotein E knockout mice

Diabetologia ◽  
2011 ◽  
Vol 54 (10) ◽  
pp. 2649-2659 ◽  
Author(s):  
M. Nagashima ◽  
T. Watanabe ◽  
M. Terasaki ◽  
M. Tomoyasu ◽  
K. Nohtomi ◽  
...  
Keyword(s):  
Apolipoprotein E ◽  
Knockout Mice ◽  
Atherosclerotic Lesions ◽  
Apolipoprotein E Knockout Mice

scholarly journals Magnetic resonance imaging of urea transporter knockout mice shows renal pelvic abnormalities

2008 ◽  
Vol 74 (9) ◽  
pp. 1202-1208 ◽  
Author(s):  
Vinitha A. Jacob ◽  
Calista M. Harbaugh ◽  
John R. Dietz ◽  
Robert A. Fenton ◽  
Soo M. Kim ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Knockout Mice ◽  
Urea Transporter ◽  
Resonance Imaging
Sign in / Sign up

Export Citation Format

Share Document