scholarly journals Significant age-related alterations in the blood plasma metabolome of noncognitively impaired healthy elderly subjects

2018 ◽  
Vol 07 (01) ◽  
Author(s):  
Xiaobei Pan ◽  
Peter Passmore ◽  
Stewart F Graham ◽  
Stephen Todd ◽  
Bernadette McGuinness ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Elderly Subjects ◽  
Healthy Elderly ◽  
Age Related ◽  
Plasma Metabolome ◽  
Healthy Elderly Subjects

scholarly journals Significant age-related alterations in the blood plasma metabolome of noncognitively impaired healthy elderly subjects

2018 ◽  
Vol 07 (01) ◽  
Author(s):  
Xiaobei Pan ◽  
Peter Passmore ◽  
Stewart F Graham ◽  
Stephen Todd ◽  
Bernadette McGuinness ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Elderly Subjects ◽  
Healthy Elderly ◽  
Age Related ◽  
Plasma Metabolome ◽  
Healthy Elderly Subjects

scholarly journals Significant age-related alterations in the blood plasma metabolome of noncognitively impaired healthy elderly subjects

2018 ◽  
Vol 7 (1) ◽  
pp. e16
Author(s):  
Xiaobei Pan ◽  
Peter Passmore ◽  
Stewart F. Graham ◽  
Stephen Todd ◽  
Bernadette McGuinness ◽  
...  
Keyword(s):  
Blood Plasma ◽  
Elderly Subjects ◽  
Healthy Elderly ◽  
Age Related ◽  
Plasma Metabolome ◽  
Healthy Elderly Subjects

scholarly journals Arginine behaviour after arginine or citrulline administration in older subjects

2015 ◽  
Vol 115 (3) ◽  
pp. 399-404 ◽  
Author(s):  
C. Moinard ◽  
J. Maccario ◽  
S. Walrand ◽  
V. Lasserre ◽  
J. Marc ◽  
...  
Keyword(s):  
Plasma Concentrations ◽  
The Elderly ◽  
Volume Of Distribution ◽  
Elderly Subjects ◽  
Healthy Elderly ◽  
Age Related ◽  
Loading Tests ◽  
Kinetics Of ◽  
Healthy Elderly Subjects

AbstractArginine (ARG) and its precursor citrulline (CIT) are popular dietary supplements, especially for the elderly. However, age-related reductions in lean body mass and alterations in organ functions could change their bioavailability. Pharmacokinetics and tolerance to amino acid (AA) loads are poorly documented in elderly subjects. The objective here was to characterise the plasma kinetics of CIT and ARG in a single-dosing study design. Eight fasting elderly men underwent two separate isomolar oral loading tests (10 g of CIT or 9·94 g of ARG). Blood was withdrawn over an 8-h period to measure plasma AA concentrations. Only CIT, ornithine and ARG plasma concentrations were changed. Volume of distribution was not dependent on AA administered. Conversely, parameters related to ARG kinetics were strongly dependent on AA administered: after ARG load, elimination was higher (ARG>CIT; P=0·041) and admission period+time at peak concentration was lower (ARG<CIT; P=0·033), and the combination of both phenomena results in a marked increase in ARG availability when CIT was administered (ARG<CIT; P=0·033) compared with ARG administration itself. In conclusion, a single CIT administration in the elderly is safe and well tolerated, and CIT proves to be a better in vivo ARG precursor than ARG itself in healthy elderly subjects.

scholarly journals Influence of a combination ofLactobacillus acidophilusNCFM and lactitol on healthy elderly: intestinal and immune parameters

2008 ◽  
Vol 101 (3) ◽  
pp. 367-375 ◽  
Author(s):  
Arthur C. Ouwehand ◽  
Kirsti Tiihonen ◽  
Markku Saarinen ◽  
Heli Putaala ◽  
Nina Rautonen
Keyword(s):  
Intestinal Microbiota ◽  
Bowel Function ◽  
Elderly Subjects ◽  
Immune Markers ◽  
Double Blind ◽  
Healthy Elderly ◽  
Immune Parameters ◽  
Age Related ◽  
Over Time ◽  
Healthy Elderly Subjects

With increasing age, a number of physiological changes take place which are reflected in immune and bowel function. These changes may relate to the commonly assumed age-related changes in intestinal microbiota; most noticeably a reduction in bifidobacteria. The current study aimed at modifying the intestinal microbiota with a potential synbiotic on selected immune and microbiota markers. Healthy elderly subjects were randomised to consume during 2 weeks either a placebo (sucrose) or a combination of lactitol andLactobacillus acidophilusNCFM twice daily in a double-blind parallel trial. After the intervention, stool frequency was higher in the synbiotic group than in the placebo group and a significant increase in faecalL. acidophilusNCFM levels was observed in the synbiotic group, after baseline correction. In contrast to the generally held opinion, the study subjects had faecalBifidobacteriumlevels that were similar to those reported in healthy young adults. These levels were, nevertheless, significantly increased by the intervention. Levels of SCFA were not changed significantly. Of the measured immune markers, PGE2levels were different between treatments and IgA levels changed over time. These changes were modest which may relate to the fact that the volunteers were healthy. Spermidine levels changed over time which may suggest an improved mucosal integrity and intestinal motility. The results suggest that consumption of lactitol combined withL. acidophilusNCFM twice daily may improve some markers of the intestinal microbiota composition and mucosal functions.

scholarly journals Longitudinal Age-Related Changes in 24-Hour Total Heart Beats and Premature Beats and Their Relationship in Healthy Elderly Subjects

2006 ◽  
Vol 47 (4) ◽  
pp. 549-563 ◽  
Author(s):  
Hirofumi Tasaki ◽  
Takumi Serita ◽  
Chiaki Ueyama ◽  
Kouei Kitano ◽  
Shinji Seto ◽  
...  
Keyword(s):  
Elderly Subjects ◽  
Healthy Elderly ◽  
Age Related ◽  
Premature Beats ◽  
Age Related Changes ◽  
Healthy Elderly Subjects

scholarly journals Age Related Change in Thyroid Function

2013 ◽  
Vol 7 (2) ◽  
pp. 72-77
Author(s):  
Shakila Rahman ◽  
Nasim Jahan ◽  
Nayma Sultana
Keyword(s):  
Thyroid Function ◽  
Thyroid Stimulating Hormone ◽  
Free Thyroxine ◽  
Elderly Subjects ◽  
Free Triiodothyronine ◽  
Serum Free ◽  
Healthy Elderly ◽  
Age Related ◽  
Healthy Elderly Subjects ◽  
Apparently Healthy

Background: Thyroid hormones play a vital role in metabolism, sensitivity of tissues to other hormones and also in oxygen consumption of almost all cells of the body. However, mild to moderate decrease in function of thyroid gland may occur with advancing age even in apparently healthy elderly subjects. Objectives: To observe age related change in thyroid function status in apparently healthy elderly subjects in Bangladesh. Methods: This cross sectional study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka between 1st January 2011 and 31st December 2011. Sixty apparently healthy elderly subjects of both sexes aged 50 to 75 years were taken as study group. They were collected from Probin Nibash Hitoishi Shangha, Agargaon, Dhaka. In addition, 30 apparently healthy young adult subjects aged 20-40 years were included as control. For assessment of thyroid function, serum free thyroxine (FT4), free triiodothyronine (FT3) and thyroid stimulating hormone (TSH) levels were estimated by ELISA method. Statistical analysis was done by one way ANOVA, Bonferroni test and Pearson’s Correlation Coefficient test as applicable. Results: In this study, mean serum free thyroxine (FT4) and free triiodothyronine (FT3) levels were significantly (p<0.001) lower and serum thyroid stimulating hormone (TSH) level was significantly (p<0.001) higher in apparently healthy elderly subjects in comparison to those of the healthy young subjects. Again, serum FT4 and FT3 levels were negatively correlated whereas serum TSH level was positively correlated with age of the subjects. Conclusion: The present study revealed a progressive decrease in thyroid function with advancement of age. DOI: http://dx.doi.org/10.3329/jbsp.v7i2.14453 J Bangladesh Soc Physiol. 2012, December; 7(2): 72-77

Quantitative aspects of glucose production and metabolism in healthy elderly subjects

Diabetes ◽  
1982 ◽  
Vol 31 (3) ◽  
pp. 203-211 ◽  
Author(s):  
J. J. Robert ◽  
J. C. Cummins ◽  
R. R. Wolfe ◽  
M. Durkot ◽  
D. E. Matthews ◽  
...  
Keyword(s):  
Glucose Production ◽  
Elderly Subjects ◽  
Healthy Elderly ◽  
Healthy Elderly Subjects

scholarly journals A Comparison of Divergent Thinking Abilities Between Healthy Elderly Subjects and MCI Patients: Preliminary Findings and Implications

2020 ◽  
Vol 11 ◽  
Author(s):  
Giulia Fusi ◽  
Elena Ferrari ◽  
Marina Zanetti ◽  
Maura Crepaldi ◽  
Carol Bersanini ◽  
...  
Keyword(s):  
Divergent Thinking ◽  
Elderly Subjects ◽  
Healthy Elderly ◽  
Healthy Elderly Subjects
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