scholarly journals Reduction of muscle protein turnover in rats by a high protein diet.

1987 ◽  
Vol 51 (1) ◽  
pp. 261-262
Author(s):  
Ryuhei FUNABUCI ◽  
Kouichi SAITO ◽  
Kazumi YAGASAKI
Keyword(s):  
Protein Turnover ◽  
Muscle Protein ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Muscle Protein Turnover

scholarly journals Muscle protein turnover and low-protein diets in patients with chronic kidney disease

2020 ◽  
Vol 35 (5) ◽  
pp. 741-751 ◽  
Author(s):  
Giacomo Garibotto ◽  
Daniela Picciotto ◽  
Michela Saio ◽  
Pasquale Esposito ◽  
Daniela Verzola
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Protein Degradation ◽  
Protein Turnover ◽  
Muscle Protein ◽  
Protein Diet ◽  
Short Term ◽  
Muscle Protein Turnover ◽  
Low Protein

Abstract Adaptation to a low-protein diet (LPD) involves a reduction in the rate of amino acid (AA) flux and oxidation, leading to more efficient use of dietary AA and reduced ureagenesis. Of note, the concept of ‘adaptation’ to low-protein intakes has been separated from the concept of ‘accommodation’, the latter term implying a decrease in protein synthesis, with development of wasting, when dietary protein intake becomes inadequate, i.e. beyond the limits of the adaptive mechanisms. Acidosis, insulin resistance and inflammation are recognized mechanisms that can increase protein degradation and can impair the ability to activate an adaptive response when an LPD is prescribed in a chronic kidney disease (CKD) patient. Current evidence shows that, in the short term, clinically stable patients with CKD Stages 3–5 can efficiently adapt their muscle protein turnover to an LPD containing 0.55–0.6 g protein/kg or a supplemented very-low-protein diet (VLPD) by decreasing muscle protein degradation and increasing the efficiency of muscle protein turnover. Recent long-term randomized clinical trials on supplemented VLPDs in patients with CKD have shown a very good safety profile, suggesting that observations shown by short-term studies on muscle protein turnover can be extrapolated to the long-term period.

scholarly journals Protein turnover in acid maltase deficiency before and after treatment with a high protein diet.

1987 ◽  
Vol 50 (5) ◽  
pp. 587-592 ◽  
Author(s):  
A M Umpleby ◽  
C M Wiles ◽  
P S Trend ◽  
I N Scobie ◽  
A F Macleod ◽  
...  
Keyword(s):  
Protein Turnover ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Acid Maltase Deficiency ◽  
Acid Maltase ◽  
Before And After

scholarly journals A high protein diet upregulates whole‐body protein turnover during energy deficit

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Lee M. Margolis ◽  
Jay J. Cao ◽  
Edward R. Sauter ◽  
Leah D. Whigham ◽  
James P. McClung ◽  
...  
Keyword(s):  
Protein Turnover ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet ◽  
Energy Deficit ◽  
Whole Body ◽  
Body Protein

scholarly journals Prolonged Adaptation to a Low or High Protein Diet Does Not Modulate Basal Muscle Protein Synthesis Rates – A Substudy

PLoS ONE ◽  
2015 ◽  
Vol 10 (9) ◽  
pp. e0137183 ◽  
Author(s):  
Rick Hursel ◽  
Eveline A. P. Martens ◽  
Hanne K. J. Gonnissen ◽  
Henrike M. Hamer ◽  
Joan M. G. Senden ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
High Protein Diet ◽  
High Protein ◽  
Protein Diet

Skeletal and cardiac muscle protein turnover during cold acclimation in young rats

2000 ◽  
Vol 278 (3) ◽  
pp. R705-R711 ◽  
Author(s):  
T. A. McAllister ◽  
J. R. Thompson ◽  
S. E. Samuels
Keyword(s):  
Skeletal Muscle ◽  
Protein Synthesis ◽  
Cardiac Muscle ◽  
Cold Acclimation ◽  
Protein Turnover ◽  
Muscle Protein ◽  
Muscle Protein Turnover ◽  
Protein Mass ◽  
The Absolute

The effect of long-term cold exposure on skeletal and cardiac muscle protein turnover was investigated in young growing animals. Two groups of 36 male 28-day-old rats were maintained at either 5°C (cold) or 25°C (control). Rates of protein synthesis and degradation were measured in vivo on days 5, 10, 15, and 20. Protein mass by day 20 was ∼28% lower in skeletal muscle (gastrocnemius and soleus) and ∼24% higher in heart in cold compared with control rats ( P < 0.05). In skeletal muscle, the fractional rates of protein synthesis ( k syn) and degradation ( k deg) were not significantly different between cold and control rats, although k syn was lower (approximately −26%) in cold rats on day 5; consequent to the lower protein mass, the absolute rates of protein synthesis (approximately −21%; P < 0.05) and degradation (approximately −13%; P < 0.1) were lower in cold compared with control rats. In heart, overall, k syn(approximately +12%; P < 0.1) and k deg(approximately +22%; P < 0.05) were higher in cold compared with control rats; consequently, the absolute rates of synthesis (approximately +44%) and degradation (approximately +54%) were higher in cold compared with control rats ( P < 0.05). Plasma triiodothyronine concentration was higher ( P < 0.05) in cold compared with control rats. These data indicate that long-term cold acclimation in skeletal muscle is associated with the establishment of a new homeostasis in protein turnover with decreased protein mass and normal fractional rates of protein turnover. In heart, unlike skeletal muscle, rates of protein turnover did not appear to immediately return to normal as increased rates of protein turnover were observed beyond day 5. These data also indicate that increased rates of protein turnover in skeletal muscle are unlikely to contribute to increased metabolic heat production during cold acclimation.

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