scholarly journals The Influence of Low Protein Diet on the Composition of Rat Liver Cell Fractions

1966 ◽  
Vol 30 (3) ◽  
pp. 274-277
Author(s):  
Naoko HARADA ◽  
Shigeaki MOGI
Keyword(s):  
Rat Liver ◽  
Liver Cell ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein ◽  
Cell Fractions

Effect of a low protein diet on restoration of the rat liver parenchyma after carbon tetrachloride poisoning

1988 ◽  
Vol 105 (3) ◽  
pp. 397-400
Author(s):  
G. N. Shorina ◽  
N. P. Bgatova ◽  
I. Simek ◽  
Z. Červinkova ◽  
M. Holeček ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Rat Liver ◽  
Liver Parenchyma ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Carbon Tetrachloride Poisoning ◽  
Low Protein

A translation repressor, 4E-BP1, regulates the triglyceride level in rat liver during protein deprivation

2020 ◽  
Vol 318 (5) ◽  
pp. E636-E645
Author(s):  
Yuka Toyoshima ◽  
Fumiaki Yoshizawa ◽  
Reiko Tokita ◽  
Yusuke Taguchi ◽  
Shin-Ichiro Takahashi ◽  
...  
Keyword(s):  
Rat Liver ◽  
Molecular Mechanisms ◽  
Mrna Level ◽  
Translation Initiation Factor ◽  
Protein Diet ◽  
Initiation Factor ◽  
Low Protein Diet ◽  
Acid Oxidation ◽  
Protein Deprivation ◽  
Low Protein

Protein deprivation has been shown to induce fatty liver in humans and animals, but the molecular mechanisms underlying such induction are largely unknown. Our previous studies have shown that a low-protein diet increases eukaryotic translation initiation factor 4E-binding protein 1 (4E-BP1) protein and triglyceride (TG) levels in rat liver. 4E-BP1 is known to repress translation by binding to eIF4E. There is also evidence indicating that 4E-BP1 regulates lipid metabolism. Here, we examined the role of 4E-BP1 on TG accumulation in the livers of rats under protein deprivation. The low-protein diet rapidly increased the hepatic 4E-BP1 mRNA level within 1 day, followed by the induction of hepatic TG accumulation. The knockdown of hepatic 4E-BP1 attenuated the TG accumulation in rat liver induced by the low-protein diet. 4E-BP1 knockdown also increased the protein level of carnitine palmitoyltransferase 1A (CPT1A), a regulator of fatty acid oxidation, in the liver of rats fed a low-protein diet. These results indicate that a low-protein diet increases the amount of 4E-BP1, leading to TG accumulation in rat liver. We thus conclude that 4E-BP1 plays an important role in inducing hepatic steatosis under protein deprivation.

The Ca2+-Transporting Activity of Rat Liver Microsomes in Response to Protein Undernutrition: Implications for Liver Tumor Promotion

2000 ◽  
Vol 20 (2) ◽  
pp. 93-98 ◽  
Author(s):  
Gbenga A. Adenuga
Keyword(s):  
Rat Liver ◽  
Protein A ◽  
Liver Microsomes ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Rat Liver Microsomes ◽  
Low Protein ◽  
Cytochrome P450 Activity ◽  
Significant Depression ◽  
P450 Activity

The effect of protein undernutrition on the activity of the smoothendoplasmic reticulum (microsomal) Ca2+-ATPase (SERCA) wasinvestigated. After 12 weeks of ad libitum ingestion of low proteindiet (5% protein), a significant depression (p<0.05) of liver ERCa2+-ATPase activity (68.6% depression) was observed. However,no significant effects on cytochrome P450 activity and relative liverweight were found. It is proposed that low protein diet by inhibitingthe rat liver SERCA activity, might increase the cytosolic free calciumion concentration ([Ca2+]) and promote the development of livertumor. The possible mechanisms of low protein diet induced inhibition ofSERCA activity are highlighted.

Hepatic Ultrastructure Changes Induced by Lithocholic Acid

1967 ◽  
Vol 25 ◽  
pp. 162-163 ◽  
Author(s):  
F. G. Zaki
Keyword(s):  
Endoplasmic Reticulum ◽  
Lithocholic Acid ◽  
Smooth Endoplasmic Reticulum ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Electron Microscopic ◽  
Hydropic Degeneration ◽  
Hepatic Cells ◽  
Low Protein ◽  
Microscopic Studies

Addition of lithocholic acid (LCA), a naturally occurring bile acid in mammals, to a low protein diet fed to rats induced marked inflammatory reaction in the hepatic cells followed by hydropic degeneration and ductular cell proliferation. These changes were accompanied by dilatation and hyperplasia of the common bile duct and formation of “gallstones”. All these changes were reversible when LCA was withdrawn from the low protein diet except for the hardened gallstones which persisted.Electron microscopic studies revealed marked alterations in the hepatic cells. Early changes included disorganization, fragmentation of the rough endoplasmic reticulum and detachment of its ribosomes. Free ribosomes, either singly or arranged in small clusters were frequently seen in most of the hepatic cells. Vesiculation of the smooth endoplasmic reticulum was often encountered as early as one week after the administration of LCA (Fig. 1).

Economic Effects of Treatment of Chronic Kidney Disease with Low-Protein Diet

2013 ◽  
Author(s):  
Francesco Saverio Mennini ◽  
Simone Russo ◽  
Andrea Marcellusi ◽  
Giuseppe Quintaliani ◽  
Denis Fouque
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Economic Effects ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Low Protein

scholarly journals Retinol and retinyl esters in parenchymal and nonparenchymal rat liver cell fractions after long-term administration of ethanol.

1985 ◽  
Vol 26 (9) ◽  
pp. 1112-1119
Author(s):  
M Rasmussen ◽  
R Blomhoff ◽  
P Helgerud ◽  
L A Solberg ◽  
T Berg ◽  
...  
Keyword(s):  
Rat Liver ◽  
Liver Cell ◽  
Term Administration ◽  
Retinyl Esters ◽  
Cell Fractions
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