Inhibition by Genistein of the Lipopolysaccharide-Induced Down-Regulation of Programmed Cell Death 4 in RAW 264.7 Mouse Macrophages

2010 ◽  
Vol 74 (5) ◽  
pp. 1095-1097 ◽  
Author(s):  
Michiko YASUDA ◽  
Kazuhiro IRIE ◽  
Akira MURAKAMI
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Raw 264.7 ◽  
Down Regulation ◽  
Mouse Macrophages ◽  
Programmed Cell Death 4

scholarly journals Globular adiponectin modulates expression of programmed cell death 4 and miR-21 in RAW 264.7 macrophages through the MAPK/NF-κB pathway

FEBS Letters ◽  
2013 ◽  
Vol 587 (10) ◽  
pp. 1556-1561 ◽  
Author(s):  
Amit Subedi ◽  
Mi Jin Kim ◽  
Saroj Nepal ◽  
Eung-Seok Lee ◽  
Jung-Ae Kim ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Raw 264.7 ◽  
Raw 264.7 Macrophages ◽  
Programmed Cell Death 4 ◽  
Globular Adiponectin

scholarly journals MiR-21 over-expression and Programmed Cell Death 4 down-regulation features malignant pleural mesothelioma

Oncotarget ◽  
2018 ◽  
Vol 9 (25) ◽  
pp. 17300-17308 ◽  
Author(s):  
Lorenzo Nicolè ◽  
Rocco Cappellesso ◽  
Tiziana Sanavia ◽  
Vincenza Guzzardo ◽  
Ambrogio Fassina
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Malignant Pleural Mesothelioma ◽  
Pleural Mesothelioma ◽  
Down Regulation ◽  
Over Expression ◽  
Programmed Cell Death 4

scholarly journals Programmed cell death 4 and BCR-ABL fusion gene expression are negatively correlated in chronic myeloid leukemia

2016 ◽  
Vol 12 (4) ◽  
pp. 2976-2981 ◽  
Author(s):  
Xia Zhang ◽  
Riming Liu ◽  
Baohua Huang ◽  
Xiaolu Zhang ◽  
Weijuan Yu ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cell Death ◽  
Chronic Myeloid Leukemia ◽  
Programmed Cell Death ◽  
Myeloid Leukemia ◽  
Fusion Gene ◽  
Programmed Cell Death 4

scholarly journals Retraction: Linc00472 suppresses breast cancer progression and enhances doxorubicin sensitivity through regulation of miR-141 and programmed cell death 4

RSC Advances ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 5895-5895
Author(s):  
Laura Fisher
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Cancer Progression ◽  
Breast Cancer Progression ◽  
Programmed Cell Death 4

Retraction of ‘Linc00472 suppresses breast cancer progression and enhances doxorubicin sensitivity through regulation of miR-141 and programmed cell death 4’ by Pengwei Lu et al., RSC Adv., 2018, 8, 8455–8468, DOI: 10.1039/C8RA00296G

The Effects of Wood Dusts on the Redox Status and Cell Death in Mouse Macrophages (Raw 264.7) and Human Leukocytes in Vitro

2003 ◽  
Vol 66 (13) ◽  
pp. 1221-1235 ◽  
Author(s):  
J. Naarala ◽  
J.-P. Kasanen ◽  
P. Pasanen ◽  
A.-L. Pasanen ◽  
A. Liimatainen ◽  
...  
Keyword(s):  
Cell Death ◽  
Redox Status ◽  
Raw 264.7 ◽  
Human Leukocytes ◽  
Mouse Macrophages

scholarly journals Programmed cell death 4 (PDCD4) expression during multistep Barrett's carcinogenesis

2010 ◽  
Vol 63 (8) ◽  
pp. 692-696 ◽  
Author(s):  
Matteo Fassan ◽  
Marco Pizzi ◽  
Giorgio Battaglia ◽  
Luciano Giacomelli ◽  
Paola Parente ◽  
...  
Keyword(s):  
Cell Death ◽  
Programmed Cell Death ◽  
Intestinal Metaplasia ◽  
Negative Regulator ◽  
Pcr Analysis ◽  
Low Grade ◽  
Cytoplasmic Staining ◽  
Programmed Cell Death 4 ◽  
Columnar Metaplasia

AimTo test the contribution of programmed cell death 4 (PDCD4) tumour suppressor gene in Barrett's carcinogenesis.MethodsPDCD4 immunohistochemical expression was assessed in 88 biopsy samples obtained from histologically proven long-segment Barrett's mucosa (BM; 25 non-intestinal columnar metaplasia, 25 intestinal metaplasia (IM), 16 low-grade intraepithelial neoplasia (LG-IEN), 12 high-grade IEN (HG-IEN) and 10 Barrett's adenocarcinoma (BAc)). As controls, 25 additional samples of native oesophageal mucosa (N) were obtained from patients with dyspepsia. To further support the data, the expression levels of miR-21, an important PDCD4 expression regulator, in 14 N, 5 HG-IEN and 11 BAc samples were determined by quantitative real-time PCR analysis.ResultsPDCD4 immunostaining decreased progressively and significantly with the progression of the phenotypic changes occurring during Barrett's carcinogenesis (p<0.001). Normal basal squamous epithelial layers featured strong PDCD4 nuclear immunoreaction (mostly coexisting with weak–moderate cytoplasmic staining). Non-intestinal columnar metaplasia and intestinal metaplasia preserved a strong nuclear immunostaining; conversely, a significant decrease in PDCD4 nuclear expression was seen in dysplastic (LG-IEN and HG-IEN) and neoplastic lesions. Weak–moderate cytoplasmic immunostaining was evident in cases of LG-IEN, while HG-IEN and BAc samples showed weak cytoplasmic or no protein expression. As expected, miR-21 expression was significantly upregulated in HG-IEN and BAc samples, consistently with PDCD4 dysregulation.ConclusionsThese data support a significant role for PDCD4 downregulation in the progression of BM to BAc, and confirm miR-21 as a negative regulator of PDCD4 in vivo. Further efforts are needed to validate PDCD4 as a potential prognostic marker in patients with Barrett's oesophagus.

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