A Freshwater Clam (Corbicula fluminea) Extract Improves Cholesterol Metabolism in Rats Fed on a High-Cholesterol Diet

2008 ◽  
Vol 72 (10) ◽  
pp. 2566-2571 ◽  
Author(s):  
Takeshi CHIJIMATSU ◽  
Iwao TATSUGUCHI ◽  
Kazuaki ABE ◽  
Hiroaki ODA ◽  
Satoshi MOCHIZUKI
Keyword(s):  
Cholesterol Metabolism ◽  
Corbicula Fluminea ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Freshwater Clam ◽  
Clam Corbicula

Lipid components prepared from a freshwater Clam (Corbicula fluminea) extract ameliorate hypercholesterolaemia in rats fed high-cholesterol diet

2013 ◽  
Vol 136 (2) ◽  
pp. 328-334 ◽  
Author(s):  
Takeshi Chijimatsu ◽  
Miki Umeki ◽  
Yutaro Kataoka ◽  
Satoru Kobayashi ◽  
Koji Yamada ◽  
...  
Keyword(s):  
Corbicula Fluminea ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Freshwater Clam ◽  
Clam Corbicula ◽  
Lipid Components

scholarly journals Rutin Supplementation on Cholesterol Metabolism in Female Albino Wistar Rats Using High‐Cholesterol‐Diet Model: Possible Renal Protection

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
SALIM S. AL-REJAIE ◽  
Hatem M. Abuohashish ◽  
Abdulaziz S. Alroujayee ◽  
Abdulaziz M. Aleisa ◽  
Osama Alkhamees
Keyword(s):  
Wistar Rats ◽  
Cholesterol Metabolism ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Renal Protection ◽  
Diet Model

scholarly journals The Effects of High Hydrostatic Pressure Extract of Mulberry Fruit on Hepatic Cholesterol Metabolism in Rats (P06-013-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Jaerin Lee ◽  
Soojin Lee ◽  
Mak-Soon Lee ◽  
Yoonjin Lee ◽  
Jiyeon Kim ◽  
...  
Keyword(s):  
Cholesterol Efflux ◽  
Cholesterol Metabolism ◽  
High Cholesterol Diet ◽  
Atp Binding ◽  
Mrna Levels ◽  
Cholesterol Diet ◽  
Hepatic Cholesterol ◽  
High Cholesterol ◽  
Mulberry Fruit ◽  
Atp Binding Cassette

Abstract Objectives The objective of this study is to investigate the effects of high hydrostatic pressure (HHP) extract of mulberry fruit on the regulation of hepatic cholesterol metabolism in high-cholesterol diet fed rats. Methods Male Sprague-Dawley rats(6-week-old) were randomly divided into 5 groups, and fed with a normal diet (NOR), High cholesterol diet (HC), HC supplemented with 0.4% mulberry (ML) or 0.8% mulberry (MH) and HC treated with statin (ST) for 4 weeks. Results The HHP extract of mulberry fruit did not affect body weight gain and food intake and reduced the serum and liver lipids in the mulberry supplemented groups (ML, MH). In this study, we found that the HHP extract of mulberry fruit changed the level of genes involved in hepatic cholesterol metabolism. In the MH group, the mRNA levels of apolipoprotein A-1 (apoA-1), ATP-binding cassette transporter A1 (ABCA1) and lecithin-cholesterol acyltransferase (LCAT), which are involved in hepatic HDL biogenesis, were significantly increased by 1.80-, 1.77- and 2.65-fold, respectively, compared with the HC group. The MH group also significantly upregulated mRNA levels of cholesterol efflux related gene such as the liver X receptor α (LXRα), ATP-binding cassette protein G5 (ABCG5) and ATP-binding cassette protein G8 (ABCG8) compared to the HC group in the liver tissue. ABCG5 and ABCG8 expression levels of the MH group were also higher than those of the ST group. The mRNA level of cholesterol 7a-hydroxylase (CYP7A1), which is bile acid synthetic rate-limiting enzyme was higher in the MH group than that of the HC group. Furthermore, the immunohistochemical staining intensity became evident for CYP7A1 in liver of the MH group. Conclusions These results suggest at least partial involvement of HDL cholesterol synthesis, cholesterol efflux and bile acid synthesis in HHP extract of mulberry fruit mediated beneficial effects on hepatic cholesterol metabolism. Funding Sources None.

Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism

2008 ◽  
Vol 295 (6) ◽  
pp. E1341-E1348 ◽  
Author(s):  
E. M. E. van Straten ◽  
N. C. A. Huijkman ◽  
J. F. W. Baller ◽  
F. Kuipers ◽  
T. Plösch
Keyword(s):  
Fetal Development ◽  
Cholesterol Metabolism ◽  
In Utero ◽  
Cholesterol Homeostasis ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fat ◽  
Hepatic Expression ◽  
Cholesterol Levels

Cholesterol is critical for several cellular functions and essential for normal fetal development. Therefore, its metabolism is tightly controlled during all life stages. The liver X receptors-α (LXRα; NR1H3) and -β (LXRβ; NR1H2) are nuclear receptors that are of key relevance in coordinating cholesterol and fatty acid metabolism. The aim of this study was to elucidate whether fetal cholesterol metabolism can be influenced in utero via pharmacological activation of LXR and whether this would have long-term effects on cholesterol homeostasis. Administration of the LXR agonist T0901317 to pregnant mice via their diet (0.015% wt/wt) led to induced fetal hepatic expression levels of the cholesterol transporter genes Abcg5/g8 and Abca1, higher plasma cholesterol levels, and lower hepatic cholesterol levels compared with controls. These profound changes during fetal development did not affect cholesterol metabolism in adulthood nor did they influence coping with a high-fat/high-cholesterol diet. This study shows that the LXR system is functional in fetal mice and susceptible to pharmacological activation. Despite massive changes in fetal cholesterol metabolism, regulatory mechanisms involved in cholesterol metabolism return to a “normal” state in offspring and allow coping with a high-fat/high-cholesterol diet.

scholarly journals Relative variations of gut microbiota in disordered cholesterol metabolism caused by high-cholesterol diet and host genetics

2017 ◽  
Vol 6 (4) ◽  
pp. e00491 ◽  
Author(s):  
Tao Bo ◽  
Shanshan Shao ◽  
Dongming Wu ◽  
Shaona Niu ◽  
Jiajun Zhao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Cholesterol Metabolism ◽  
High Cholesterol Diet ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
Host Genetics
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