Protective Effects of an Extract of Young Radish (Raphanus sativus L) Cultivated with Sulfur (Sulfur-Radish Extract) and of Sulforaphane on Carbon Tetrachloride-Induced Hepatotoxicity

2008 ◽  
Vol 72 (5) ◽  
pp. 1176-1182 ◽  
Author(s):  
Seung-Hae BAEK ◽  
Min PARK ◽  
Jae-Hee SUH ◽  
Hye-Seon CHOI
Keyword(s):  
Carbon Tetrachloride ◽  
Raphanus Sativus ◽  
Protective Effects ◽  
Raphanus Sativus L

Protective Effect of Fresh Radish Juice (Raphanus sativus L.) Against Carbon Tetrachloride-Induced Hepatotoxicity

2008 ◽  
Vol 4 (2) ◽  
pp. 130-134 ◽  
Author(s):  
Syed Rafatullah ◽  
Abdulmalik Al-Sheikh ◽  
Saleh Alqsoumi ◽  
Mohammed Al-Yahya ◽  
Kamal El-Tahir ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Protective Effect ◽  
Raphanus Sativus ◽  
Raphanus Sativus L

Isolation of the constituents and evaluation of allelopathic potential of Raphanus sativus L. (Brassicaceae)

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
LLR Fiorucci ◽  
GC Mantovanelli ◽  
DI Bernardi ◽  
AA Silva ◽  
RS de Oliveira Jr ◽  
...  
Keyword(s):  
Raphanus Sativus ◽  
Allelopathic Potential ◽  
Raphanus Sativus L

Inhibitory Effect of Black Radish Extract (Raphanus sativus L. var. niger) on Adipogenesis in 3T3-L1 Cells

2019 ◽  
Vol 48 (8) ◽  
pp. 811-822
Author(s):  
Dawun Yang ◽  
Seunghyun Hong ◽  
Hak Sung Lee ◽  
Nam Ho Lee ◽  
Taekyun Shin ◽  
...  
Keyword(s):  
Raphanus Sativus ◽  
Inhibitory Effect ◽  
Raphanus Sativus L

scholarly journals Lemon Balm and Dandelion Leaf Extracts Synergistically Protect against Carbon Tetrachloride-Induced Acute Liver Injury in Mice

2021 ◽  
Vol 11 (1) ◽  
pp. 390
Author(s):  
Beom-Rak Choi ◽  
Il-Je Cho ◽  
Su-Jin Jung ◽  
Jae-Kwang Kim ◽  
Dae-Geon Lee ◽  
...  
Keyword(s):  
Carbon Tetrachloride ◽  
Liver Injury ◽  
Acute Liver Injury ◽  
Antioxidant Activities ◽  
Body Weight Gain ◽  
Histopathological Analysis ◽  
Related Factor ◽  
Mrna Levels ◽  
Protective Effects ◽  
Lemon Balm

Lemon balm and dandelion are commonly used medicinal herbs exhibiting numerous pharmacological activities that are beneficial for human health. In this study, we explored the protective effects of a 2:1 (w/w) mixture of lemon balm and dandelion extracts (MLD) on carbon tetrachloride (CCl4)-induced acute liver injury in mice. CCl4 (0.5 mL/kg; i.p.) injection inhibited body weight gain and increased relative liver weight. Pre-administration of MLD (50–200 mg/kg) for 7 days prevented these CCl4-mediated changes. In addition, histopathological analysis revealed that MLD synergistically alleviated CCl4-mediated hepatocyte degeneration and infiltration of inflammatory cells. MLD decreased serum aspartate aminotransferase and alanine transferase activities and reduced the number of liver cells that stained positive for cleaved caspase-3 and cleaved poly(ADP-ribose) polymerase, suggesting that MLD protects against CCl4-induced hepatic damage via the inhibition of apoptosis. Moreover, MLD attenuated CCl4-mediated lipid peroxidation and protein nitrosylation by restoring impaired hepatic nuclear factor erythroid 2-related factor 2 mRNA levels and its dependent antioxidant activities. Furthermore, MLD synergistically decreased mRNA and protein levels of tumor necrosis factor-α, interleukin-1β, and interleukin-6 in the liver. Together, these results suggest that MLD has potential for preventing acute liver injury by inhibiting apoptosis, oxidative stress, and inflammation.

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