scholarly journals Novel Antifungal Compounds Produced by Sterile Dark, an Unidentified Wheat Rhizosphere Fungus

2005 ◽  
Vol 69 (5) ◽  
pp. 1018-1020 ◽  
Author(s):  
Kosaku TAKAHASHI ◽  
Hiroyuki KOSHINO ◽  
Yasusaburo NARITA ◽  
Teruhiko YOSHIHARA
Keyword(s):  
Antifungal Compounds ◽  
Wheat Rhizosphere ◽  
Rhizosphere Fungus

Synthesis of novel antifungal phthalides produced by a wheat rhizosphere fungus

Tetrahedron ◽  
2008 ◽  
Vol 64 (38) ◽  
pp. 9073-9077 ◽  
Author(s):  
Naoto Katoh ◽  
Takashi Nakahata ◽  
Shigefumi Kuwahara
Keyword(s):  
Wheat Rhizosphere ◽  
Rhizosphere Fungus

Alternative Host Models for Testing Anti-Protozoal or Antifungal Compounds and Fungal Infection

2018 ◽  
Vol 18 (4) ◽  
pp. 300-311
Author(s):  
Ana Claudia Torrecilhas ◽  
Patricia Xander ◽  
Karen Spadari Ferreira ◽  
Wagner Luiz Batista
Keyword(s):  
Fungal Infection ◽  
Neglected Tropical Diseases ◽  
Alternative Methods ◽  
Laboratory Animals ◽  
Antifungal Compounds ◽  
Alternative Host ◽  
Control And Prevention ◽  
New Compounds ◽  
Invertebrate Models ◽  
Alternative Drugs

The neglected tropical diseases (NTDs) are caused by several parasites, fungi, bacteria and viruses and affect more than one billion people in the world. The control and prevention against NTDs need implementation of alternative methods for testing new compounds against these diseases. For the implementation of alternative methods, it is necessary to apply the principles of replacement, reduction and refinement (the 3Rs) for the use of laboratory animals. Accordingly, the present review addressed a variety of alternative models to study the infections caused by protozoa and fungi. Overall, vertebrate and invertebrate models of fungal infection have been used to elucidate host-pathogen interactions. However, until now the insect model has not been used in protozoal studies as an alternative method, but there is interest in the scientific community to try new tools to screen alternative drugs to control and prevent protozoal infections.

scholarly journals Diffusible Compounds Produced by Hanseniaspora osmophila and Gluconobacter cerinus Help to Control the Causal Agents of Gray Rot and Summer Bunch Rot of Table Grapes

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 664
Author(s):  
Matías Olivera ◽  
Ninoska Delgado ◽  
Fabiola Cádiz ◽  
Natalia Riquelme ◽  
Iván Montenegro ◽  
...  
Keyword(s):  
Mycelial Growth ◽  
Inhibitory Effect ◽  
Biocontrol Agents ◽  
Environmental Cost ◽  
Antifungal Compounds ◽  
Table Grapes ◽  
Dual Cultures ◽  
Bunch Rot ◽  
Direct Bioautography

Gray and summer bunch rot are important diseases of table grapes due to the high economic and environmental cost of their control with synthetic fungicides. The ability to produce antifungal compounds against the causal agents Botrytis, Aspergillus, Penicillium, and Rhizopus of two microorganisms isolated from table grapes and identified as Hanseniaspora osmophila and Gluconobacter cerinus was evaluated. In dual cultures, both biocontrol agents (together and separately) inhibited in vitro mycelial growth of these pathogens. To identify the compounds responsible for the inhibitory effect, extractions were carried out with organic solvents from biocontrol agents separately. Through dual cultures with pathogens and pure extracts, only the hexane extract from H. osmophila showed an inhibitory effect against Botrytis cinerea. To further identify these compounds, the direct bioautography technique was used. This technique made it possible to determine the band displaying antifungal activity at Rf = 0.05–0.2. The compounds present in this band were identified by GC-MS and compared to the NIST library. The most abundant compounds, not previously reported, corresponded to alkanes, ketones, alcohols, and terpenoids. H. osmophila and G. cerinus have the potential to control the causal agents of gray and summer bunch rot of table grapes.

scholarly journals Bio-herbicidal potential of wheat rhizosphere bacteria on Avena fatua L. grass

Bioengineered ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 516-526
Author(s):  
Wei Li ◽  
Shuo Shen ◽  
Hongyu Chen
Keyword(s):  
Avena Fatua ◽  
Rhizosphere Bacteria ◽  
Wheat Rhizosphere

scholarly journals Nicotinamide Effectively Suppresses Fusarium Head Blight in Wheat Plants

2021 ◽  
Vol 22 (6) ◽  
pp. 2968
Author(s):  
Yasir Sidiq ◽  
Masataka Nakano ◽  
Yumi Mori ◽  
Takashi Yaeno ◽  
Makoto Kimura ◽  
...  
Keyword(s):  
Fusarium Head Blight ◽  
Fungal Pathogen ◽  
Antifungal Compounds ◽  
Pyridine Nucleotides ◽  
Fungal Metabolites ◽  
Dna Hypomethylation ◽  
Metabolome Analysis ◽  
Head Blight ◽  
Ergosterol Peroxide ◽  
Nicotinamide Mononucleotide

Pyridine nucleotides such as a nicotinamide adenine dinucleotide (NAD) are known as plant defense activators. We previously reported that nicotinamide mononucleotide (NMN) enhanced disease resistance against fungal pathogen Fusarium graminearum in barley and Arabidopsis. In this study, we reveal that the pretreatment of nicotinamide (NIM), which does not contain nucleotides, effectively suppresses disease development of Fusarium Head Blight (FHB) in wheat plants. Correspondingly, deoxynivalenol (DON) mycotoxin accumulation was also significantly decreased by NIM pretreatment. A metabolome analysis showed that several antioxidant and antifungal compounds such as trigonelline were significantly accumulated in the NIM-pretreated spikes after inoculation of F. graminearum. In addition, some metabolites involved in the DNA hypomethylation were accumulated in the NIM-pretreated spikes. On the other hand, fungal metabolites DON and ergosterol peroxide were significantly reduced by the NIM pretreatment. Since NIM is relative stable and inexpensive compared with NMN and NAD, it may be more useful for the control of symptoms of FHB and DON accumulation in wheat and other crops.

scholarly journals Mycotoxins Biocontrol Methods for Healthier Crops and Stored Products

2021 ◽  
Vol 7 (5) ◽  
pp. 348
Author(s):  
Kristina Habschied ◽  
Vinko Krstanović ◽  
Zvonimir Zdunić ◽  
Jurislav Babić ◽  
Krešimir Mastanjević ◽  
...  
Keyword(s):  
Food Safety ◽  
Human Health ◽  
Fungal Growth ◽  
Antifungal Compounds ◽  
Stored Products ◽  
Soil Air ◽  
Recent Advances ◽  
Environmental Systems ◽  
Antifungal Substances

Contamination of crops with phytopathogenic genera such as Fusarium, Aspergillus, Alternaria, and Penicillium usually results in mycotoxins in the stored crops or the final products (bread, beer, etc.). To reduce the damage and suppress the fungal growth, it is common to add antifungal substances during growth in the field or storage. Many of these antifungal substances are also harmful to human health and the reduction of their concentration would be of immense importance to food safety. Many eminent researchers are seeking a way to reduce the use of synthetic antifungal compounds and to implement more eco-friendly and healthier bioweapons against fungal proliferation and mycotoxin synthesis. This paper aims to address the recent advances in the effectiveness of biological antifungal compounds application against the aforementioned fungal genera and their species to enhance the protection of ecological and environmental systems involved in crop growing (water, soil, air) and to reduce fungicide contamination of food derived from these commodities.

scholarly journals Plant Disease Control Efficacy of Platycladus orientalis and Its Antifungal Compounds

Plants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1496
Author(s):  
Sohyun Bae ◽  
Jae Woo Han ◽  
Quang Le Dang ◽  
Hun Kim ◽  
Gyung Ja Choi
Keyword(s):  
Disease Control ◽  
Rice Blast ◽  
Plant Disease ◽  
Methanol Extract ◽  
Crop Protection ◽  
Ethyl Acetate Fraction ◽  
Antifungal Compounds ◽  
Control Efficacy ◽  
Platycladus Orientalis ◽  
Plant Disease Control

Plants contain a number of bioactive compounds that exhibit antimicrobial activity, which can be recognized as an important source of agrochemicals for plant disease control. In searching for natural alternatives to synthetic fungicides, we found that a methanol extract of the plant species Platycladus orientalis suppressed the disease development of rice blast caused by Magnaporthe oryzae. Through a series of chromatography procedures in combination with activity-guided fractionation, we isolated and identified a total of eleven compounds including four labdane-type diterpenes (1–4), six isopimarane-type diterpenes (5–10), and one sesquiterpene (11). Of the identified compounds, the MIC values of compounds 1, 2, 5 & 6 mixture, 9, and 11 ranged from 100 to 200 μg/mL against M. oryzae, whereas the other compounds were over 200 μg/mL. When rice plants were treated with the antifungal compounds, compounds 1, 2, and 9 effectively suppressed the development of rice blast at all concentrations tested by over 75% compared to the non-treatment control. In addition, a mixture of compounds 5 & 6 that constituted 66% of the P. orientalis ethyl acetate fraction also exhibited a moderate disease control efficacy. Together, our data suggest that the methanol extract of P. orientalis including terpenoid compounds has potential as a crop protection agent.

scholarly journals Preformed antifungal compounds in strawberry fruit and flower tissues

2004 ◽  
Vol 31 (2) ◽  
pp. 201-212 ◽  
Author(s):  
Leon A Terry ◽  
Daryl C Joyce ◽  
Nimal K.B Adikaram ◽  
Bhupinder P.S Khambay
Keyword(s):  
Antifungal Compounds ◽  
Strawberry Fruit
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