scholarly journals Adenovirus-mediated Suicide Gene Therapy Using the Human Telomerase Catalytic Subunit (hTERT) Gene Promoter Induced Apoptosis of Ovarian Cancer Cell Line

2003 ◽  
Vol 67 (11) ◽  
pp. 2344-2350 ◽  
Author(s):  
Joon-Seok SONG ◽  
Hyun-Pyo KIM ◽  
Won-Suck YOON ◽  
Kyu-Wan LEE ◽  
Mee-Hye KIM ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Gene Therapy ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Gene Promoter ◽  
Cancer Cell Line ◽  
Suicide Gene ◽  
Htert Gene ◽  
Induced Apoptosis ◽  
Human Telomerase

Mechanisms of Paclitaxel-Induced Apoptosis in an Ovarian Cancer Cell Line and Its Paclitaxel-Resistant Clone

Oncology ◽  
2004 ◽  
Vol 66 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Masaki Sugimura ◽  
Satoru Sagae ◽  
Shin-ichi Ishioka ◽  
Yoshihiro Nishioka ◽  
Kuniko Tsukada ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Resistant Clone ◽  
Induced Apoptosis

scholarly journals Extracellular Matrix Proteins Expression Profiling in Chemoresistant Variants of the A2780 Ovarian Cancer Cell Line

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Radosław Januchowski ◽  
Piotr Zawierucha ◽  
Marcin Ruciński ◽  
Michał Nowicki ◽  
Maciej Zabel
Keyword(s):  
Ovarian Cancer ◽  
Extracellular Matrix ◽  
Drug Resistance ◽  
Cell Line ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Altered Expression ◽  
Expression Levels

Ovarian cancer is the leading cause of death among gynaecological malignancies. Extracellular matrix (ECM) can affect drug resistance by preventing the penetration of the drug into cancer cells and increased resistance to apoptosis. This study demonstrates alterations in the expression levels of ECM components and related genes in cisplatin-, doxorubicin-, topotecan-, and paclitaxel-resistant variants of the A2780 ovarian cancer cell line. Affymetrix Gene Chip Human Genome Array Strips were used for hybridisations. The genes that had altered expression levels in drug-resistant sublines were selected and filtered by scatter plots. The genes that were up- or downregulated more than fivefold were selected and listed. Among the investigated genes, 28 genes were upregulated, 10 genes were downregulated, and two genes were down- or upregulated depending on the cell line. Between upregulated genes 12 were upregulated very significantly—over 20-fold. These genes included COL1A2, COL12A1, COL21A1, LOX, TGFBI, LAMB1, EFEMP1, GPC3, SDC2, MGP, MMP3, and TIMP3. Four genes were very significantly downregulated: COL11A1, LAMA2, GPC6, and LUM. The expression profiles of investigated genes provide a preliminary insight into the relationship between drug resistance and the expression of ECM components. Identifying correlations between investigated genes and drug resistance will require further analysis.

scholarly journals Involvement of adaptor protein Crk in malignant feature of human ovarian cancer cell line MCAS

Oncogene ◽  
2006 ◽  
Vol 25 (25) ◽  
pp. 3547-3556 ◽  
Author(s):  
H Linghu ◽  
M Tsuda ◽  
Y Makino ◽  
M Sakai ◽  
T Watanabe ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Adaptor Protein ◽  
Cancer Cell Line ◽  
Human Ovarian Cancer ◽  
Human Ovarian Cancer Cell ◽  
Malignant Feature

Src tyrosine kinase promotes survival and resistance to chemotherapeutics in a mouse ovarian cancer cell line

2003 ◽  
Vol 309 (2) ◽  
pp. 377-383 ◽  
Author(s):  
Yolande Pengetnze ◽  
Mary Steed ◽  
Katherine F. Roby ◽  
Paul F. Terranova ◽  
Christopher C. Taylor
Keyword(s):  
Ovarian Cancer ◽  
Tyrosine Kinase ◽  
Cell Line ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Src Tyrosine Kinase

Isolation and characterization of stem-like cells from a human ovarian cancer cell line

2011 ◽  
Vol 363 (1-2) ◽  
pp. 257-268 ◽  
Author(s):  
Lijuan Wang ◽  
Roman Mezencev ◽  
Nathan J. Bowen ◽  
Lilya V. Matyunina ◽  
John F. McDonald
Keyword(s):  
Ovarian Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Ovarian Cancer Cell ◽  
Ovarian Cancer Cell Line ◽  
Cancer Cell Line ◽  
Human Ovarian Cancer ◽  
Human Ovarian Cancer Cell ◽  
Isolation And Characterization
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