scholarly journals Replication Timing Properties within the Mouse Distal Chromosome 7 Imprinting Cluster

2002 ◽  
Vol 66 (5) ◽  
pp. 1046-1051 ◽  
Author(s):  
Kazuhiro KAGOTANI ◽  
Shin-ichiro TAKEBAYASHI ◽  
Atsushi KOHDA ◽  
Hiroshi TAGUCHI ◽  
Martina PAULSEN ◽  
...  
Keyword(s):  
Replication Timing ◽  
Chromosome 7 ◽  
Distal Chromosome ◽  
Timing Properties

Localization of the Mouse Gene (Bc1) Encoding Neural BC1 RNA Near the Fibroblast Growth Factor 3 Locus (Fgf3) on Distal Chromosome 7

Genomics ◽  
1997 ◽  
Vol 44 (1) ◽  
pp. 153-154 ◽  
Author(s):  
Benjamin A. Taylor ◽  
Ann Navin ◽  
Boris V. Skryabin ◽  
Jürgen Brosius
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Mouse Gene ◽  
Chromosome 7 ◽  
Fibroblast Growth ◽  
Distal Chromosome

scholarly journals Cdkn1c (p57Kip2) is the major regulator of embryonic growth within its imprinted domain on mouse distal chromosome 7

2007 ◽  
Vol 7 (1) ◽  
pp. 53 ◽  
Author(s):  
Stuart C Andrews ◽  
Michelle D Wood ◽  
Simon J Tunster ◽  
Sheila C Barton ◽  
Azim M Surani ◽  
...  
Keyword(s):  
Chromosome 7 ◽  
Embryonic Growth ◽  
Distal Chromosome

Murine Stim1 maps to distal Chromosome 7 and is not imprinted

1998 ◽  
Vol 9 (8) ◽  
pp. 657-659 ◽  
Author(s):  
Maree L. Overall ◽  
Nigel J. Parker ◽  
Deborah L. Scarcella ◽  
Peter J. Smith ◽  
Marie Dziadek
Keyword(s):  
Chromosome 7 ◽  
Distal Chromosome

scholarly journals Phemx, a Novel Mouse Gene Expressed in Hematopoietic Cells Maps to the Imprinted Cluster on Distal Chromosome 7

Genomics ◽  
2000 ◽  
Vol 68 (1) ◽  
pp. 13-21 ◽  
Author(s):  
Rhonda H. Nicholson ◽  
Serafino Pantano ◽  
James F. Eliason ◽  
Anne Galy ◽  
Sarah Weiler ◽  
...  
Keyword(s):  
Hematopoietic Cells ◽  
Mouse Gene ◽  
Chromosome 7 ◽  
Distal Chromosome ◽  
Imprinted Cluster

scholarly journals Syntenic Organization of the Mouse Distal Chromosome 7 Imprinting Cluster and the Beckwith-Wiedemann Syndrome Region in Chromosome 11p15.5

1998 ◽  
Vol 7 (7) ◽  
pp. 1149-1159 ◽  
Author(s):  
M. Paulsen ◽  
K. R. Davies ◽  
L. M. Bowden ◽  
A. J. Villar ◽  
O. Franck ◽  
...  
Keyword(s):  
Chromosome 7 ◽  
Distal Chromosome ◽  
Chromosome 11P15.5

Mtr1, a Novel Biallelically Expressed Gene in the Center of the Mouse Distal Chromosome 7 Imprinting Cluster, is a Member of the Trp Gene Family

Genomics ◽  
2000 ◽  
Vol 67 (2) ◽  
pp. 179-187 ◽  
Author(s):  
Thorsten Enklaar ◽  
Marion Eßwein ◽  
Monika Oswald ◽  
Katja Hilbert ◽  
Andreas Winterpacht ◽  
...  
Keyword(s):  
Gene Family ◽  
Chromosome 7 ◽  
Distal Chromosome

scholarly journals Mechanism of imprinting on mouse distal chromosome 7

1998 ◽  
Vol 72 (3) ◽  
pp. 237-245 ◽  
Author(s):  
JUSTIN F-X. AINSCOUGH ◽  
ROSALIND M. JOHN ◽  
M. AZIM SURANI
Keyword(s):  
Chromosome 7 ◽  
Parental Origin ◽  
Imprinted Genes ◽  
Critical Feature ◽  
Male Germline ◽  
Domain Type ◽  
Distal Chromosome ◽  
Type Mode ◽  
Single Allele ◽  
Female Germline

Genomic imprinting is an epigenetic mode of gene regulation that results in expression of the autosomal ‘imprinted’ genes from only a single allele, determined exclusively by parental origin. To date over 20 imprinted genes have been identified in mouse and man and these appear to lie in clusters in restricted regions on a subset of chromosomes. This may be a critical feature of imprinting suggesting a domain-type mode of regulation. Imprinted domains are replicated asynchronously, show sex-specific meiotic recombination frequencies and have CpG-rich regions that are differentially methylated, often associated with the imprinted genes themselves. Mouse distal chromosome 7 is one such domain, containing at least nine imprinted genes spanning over 1 Mb of DNA. For the maternally expressed p57Kip2 gene, passage through the female germline is essential to generate the active state, whereas passage through the male germline is needed to force the maternally expressed H19 gene into an inactive state. It is therefore possible that the mouse distal chromosome 7 imprinted domain is actually composed of two or more independently regulated subdomains.

Mouse embryos with paternal duplication of an imprinted chromosome 7 region die at midgestation and lack placental spongiotrophoblast

Development ◽  
1996 ◽  
Vol 122 (1) ◽  
pp. 265-270 ◽  
Author(s):  
K.J. McLaughlin ◽  
P. Szabo ◽  
H. Haegel ◽  
J.R. Mann
Keyword(s):  
Mouse Embryos ◽  
Chromosome 7 ◽  
Imprinted Genes ◽  
Uniparental Inheritance ◽  
Aberrant Expression ◽  
Distal Chromosome ◽  
Specific Activities ◽  
Androgenetic Embryos ◽  
Genomic Regions ◽  
Chromosome Regions

Imprinted genomic regions have been defined by the production of mice with uniparental inheritance or duplication of homologous chromosome regions. With most of the genome investigated, paternal duplication of only distal chromosomes 7 and 12 results in the lack of offspring, and prenatal lethality is presumed. Aberrant expression of imprinted genes in these two autosomal regions is therefore strongly implicated in the periimplantation lethality of androgenetic embryos. We report that mouse embryos with paternal duplication of distal chromosome 7 (PatDup.d7) die at midgestation and lack placental spongiotrophoblast. Thus, the much earlier death of androgenones must involve paternal duplication of other autosomal regions, acting independently of or synergistically with PatDup.d7. The phenotype observed is similar, if not identical to, that resulting from mutation of the imprinted distal chromosome 7 gene, Mash2, which in normal midgestation embryos exhibits spongiotrophoblast-specific maternally active/paternally inactive (m+/p-) allelic expression. Thus, the simplest explanation for the PatDup.d7 phenotype is p-/p- expression of this gene. We also confirm that PatDup.d7 embryos lack H19 RNA and posses excess Igf2 RNA as might be expected from the parental-specific activities of these genes in normal embryos.

scholarly journals The two-domain hypothesis in Beckwith–Wiedemann syndrome: autonomous imprinting of the telomeric domain of the distal chromosome 7 cluster

2005 ◽  
Vol 14 (4) ◽  
pp. 503-511 ◽  
Author(s):  
Flavia Cerrato ◽  
Angela Sparago ◽  
Ines Di Matteo ◽  
Xiangang Zou ◽  
Wendy Dean ◽  
...  
Keyword(s):  
Chromosome 7 ◽  
Distal Chromosome
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