scholarly journals Dietary Conjugated Linoleic Acid Increases Immunoglobulin Productivity of Sprague-Dawley Rat Spleen Lymphocytes

2000 ◽  
Vol 64 (10) ◽  
pp. 2159-2164 ◽  
Author(s):  
Masao YAMASAKI ◽  
Koji KISHIHARA ◽  
Keiko MANSHO ◽  
Yuuya OGINO ◽  
Masaaki KASAI ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Sprague Dawley ◽  
Sprague Dawley Rat ◽  
Dietary Conjugated Linoleic Acid ◽  
Spleen Lymphocytes

scholarly journals Dietary conjugated linoleic acid (CLA) induces apoptosis of colonic mucosa in 1,2-dimethylhydrazine-treated rats: a possible mechanism of the anticarcinogenic effect by CLA

2001 ◽  
Vol 86 (5) ◽  
pp. 549-555 ◽  
Author(s):  
Hyun S. Park ◽  
Ji H. Ryu ◽  
Yeong L. Ha ◽  
Jung H. Y. Park
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Control Diet ◽  
Terminal Deoxynucleotidyl Transferase ◽  
Prostaglandin E ◽  
Dependent Manner ◽  
Sprague Dawley ◽  
Tumour Incidence ◽  
Sprague Dawley Rats ◽  
Dietary Conjugated Linoleic Acid

One of the objectives of the present study was to investigate whether 1 % conjugated linoleic acid (CLA) in the diet reduced tumour incidence in the colon of 1,2-dimethylhydrazine (DMH)-treated rats. Colon cancer was induced by injecting 6-week-old, male, Sprague–Dawley rats with 15 mg/kg DMH twice per week for 6 weeks. They were fed either 1 % CLA or a control diet ad libitum for 30 weeks. Dietary CLA significantly decreased colon tumour incidence (P<0·05). Our second objective was to investigate whether apoptosis in the colon mucosa of DMH-treated rats was affected by the amount of dietary CLA and whether the changes in apoptosis were related to those in fatty acid-responsive biomarkers. For this purpose, rats were killed after being fed a diet containing 0 %, 0·5 %, 1 % or 1·5 % CLA for 14 weeks. CLA was undetected in the mucosa of rats fed the 0 % CLA diet and increased to 5·9 mg/g phospholipid in rats fed the 0·5 % diet. The apoptotic index estimated by the terminal deoxynucleotidyl transferase-mediated dUTP nick and labelling technique was increased by 251 % and the 1,2-diacylglycerol content was decreased by 57 % in rats fed 0·5 % CLA. No further changes in these variables were observed when CLA in the diet was raised to 1·0 % or 1·5 %. However, dietary CLA decreased mucosal levels of prostaglandin E2, thromboxane B2 and arachidonic acid in a dose-dependent manner. The present data indicate that dietary CLA can inhibit DMH-induced colon carcinogenesis by mechanisms probably involving increased apoptosis.

Acute reduction of serum leptin level by dietary conjugated linoleic acid in Sprague-Dawley rats

2000 ◽  
Vol 11 (9) ◽  
pp. 467-471 ◽  
Author(s):  
Masao Yamasaki ◽  
Keiko Mansho ◽  
Yuuya Ogino ◽  
Masaaki Kasai ◽  
Hirofumi Tachibana ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Sprague Dawley ◽  
Serum Leptin ◽  
Sprague Dawley Rats ◽  
Dietary Conjugated Linoleic Acid

Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets

Nutrition ◽  
2003 ◽  
Vol 19 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Masao Yamasaki ◽  
Atsushi Ikeda ◽  
Mariko Oji ◽  
Yoko Tanaka ◽  
Akira Hirao ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Body Fat ◽  
Sprague Dawley ◽  
Serum Leptin ◽  
Sprague Dawley Rats ◽  
Dietary Conjugated Linoleic Acid ◽  
Fat Level
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