scholarly journals Effect of Dietary Antioxidants on Serum Lipid Contents and Immunoglobulin Productivity of Lymphocytes in Sprague-Dawley Rats

1999 ◽  
Vol 63 (3) ◽  
pp. 575-576 ◽  
Author(s):  
Shihoko KAKU ◽  
Shin-ichi YUNOKI ◽  
Mitsuo MORI ◽  
Ken-ichi OHKURA ◽  
Michiko NONAKA ◽  
...  
Keyword(s):  
Serum Lipid ◽  
Sprague Dawley ◽  
Dietary Antioxidants ◽  
Lipid Contents ◽  
Sprague Dawley Rats

scholarly journals The effects of polyunsaturated:saturated fatty acids ratios and peroxidisability index values of dietary fats on serum lipid profiles and hepatic enzyme activities in rats

2005 ◽  
Vol 94 (4) ◽  
pp. 526-532 ◽  
Author(s):  
Min Jeong Kang ◽  
Myoung Suk Shin ◽  
Jung Nan Park ◽  
Sang Sun Lee
Keyword(s):  
Fatty Acids ◽  
Enzyme Activities ◽  
Serum Lipid ◽  
Hdl Cholesterol ◽  
Thiobarbituric Acid ◽  
Dietary Fats ◽  
Thiobarbituric Acid Reactive Substance ◽  
Hepatic Enzyme ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Raising the dietary PUFA:saturated fatty acids (SFA) ratio has been recommended for the prevention of CVD. However, a high PUFA:SFA (P:S) ratio diet enhances oxidative stress because PUFA are highly susceptible to lipid peroxidation. Thus, we focused on the role of the dietary P:S ratio and peroxidisability index (PI) value on serum and liver tissue and investigated the effects of dietary P:S ratios (0·4, 1·0, and 4·8) with a fixed PI value (81) on serum lipid parameters and hepatic enzyme activities (experiment 1). To elucidate whether those phenomena were unique to the P:S ratio, we examined the effects of dietary PI values (36, 81, 126, and 217) with a constant P:S ratio (1·0) (experiment 2). Female Sprague–Dawley rats weighing 240–280 g were fed experimental diets for 4 weeks. When dietary PI value was maintained at 81, serum HDL-cholesterol (HDL-C) increased with increasing dietary P:S ratio. When the P:S ratio was fixed at 1·0, HDL-C was the lowest with mid–low PI (MLPI) (PI value of 81). In both experiments, serum LDL-cholesterol:HDL-C ratio kept in the range of 0–2. The hepatic superoxide dismutase, catalase, and glutathione peroxidase (GSH-Px) activities and thiobarbituric acid reactive substance (TBARS) concentrations were the highest in the lowest dietary P:S ratio group (experiment 1). GSH-Px, glutathione-S-transferase, and TBARS were the lowest in rats fed the MLPI diet (experiment 2). In conclusion, these results indicate that a P:S ratio of 1·0–1·5 and a PI value of 80–90 in the diet are within a favourable range to reduce the risk of CVD.

Antihypercholesterolemia Effect of Acalypha indica L. to Serum Lipid Profile and Histopathology Liver on Sprague Dawley Rats: Focused on Gemfibrozil as a Control

2017 ◽  
Vol 23 (7) ◽  
pp. 6966-6969 ◽  
Author(s):  
Rani Wardani Hakim ◽  
Melisa Leviana ◽  
Desak Gede Budi Krisnamurti ◽  
Taufik Budianto ◽  
Hardya Gustada ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Acalypha Indica

Toxic effects of subacute inhalation exposure to trichloroethylene on serum lipid profile, glucose and biochemical parameters in Sprague–Dawley rats

2018 ◽  
Vol 30 (9-10) ◽  
pp. 354-360
Author(s):  
Zahra Zamanian ◽  
Saeed Yousefinejad ◽  
Mohammad Javad Khoshnoud ◽  
Farideh Golbabaie ◽  
Somayeh Farhang Dehghan ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Biochemical Parameters ◽  
Inhalation Exposure ◽  
Toxic Effects ◽  
Serum Lipid Profile ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Weight reduction with improvement of serum lipid profile and ratios of Sesamum radiatum leaves diet in a non-obese Sprague Dawley rats

2007 ◽  
Vol 6 (21) ◽  
pp. 2428-2433 ◽  
Author(s):  
A J Shittu Lukeman ◽  
A Bankole Munir ◽  
A Ogundipe Olufemi ◽  
Falade A K ◽  
K Shittu Remilekun ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Weight Reduction ◽  
Serum Lipid ◽  
Serum Lipid Profile ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Effect of guar gum on the serum lipid profile of Sprague Dawley rats

LWT ◽  
2007 ◽  
Vol 40 (7) ◽  
pp. 1198-1205 ◽  
Author(s):  
Naureen Shahzadi ◽  
Masood S. Butt ◽  
Mian K. Sharif ◽  
Muhammad Nasir
Keyword(s):  
Lipid Profile ◽  
Serum Lipid ◽  
Guar Gum ◽  
Serum Lipid Profile ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Ultrastructural Investigation of Spontaneous Pituitary Adenomas in Aging Sprague-Dawley Rats

1982 ◽  
Vol 40 ◽  
pp. 216-217
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Microscopic Study ◽  
Pituitary Adenomas ◽  
Wistar Rats ◽  
Microscopic Level ◽  
Sprague Dawley ◽  
Prolactin Cells ◽  
Light Microscopic Level ◽  
Ultrastructural Investigation ◽  
Sprague Dawley Rats ◽  
Long Evans

Investigation of the spontaneous pituitary adenomas in rat have been limited mainly to light microscopic study. Furth et al. (1973) described them as chromophobic, secreting prolactin. Kovacs et al. (1977) in an ul trastructural investigation of adenomas of old female Long-Evans rats, found that they were composed of prolactin cells. Berkvens et al. (1980) using immunocytochemistry at the light microscopic level, demonstrated that some spontaneous tumors of old Wistar rats could contain GH, TSH or ACTH as well as PRL.

Early Development of Drug-Induced Hepatic Necrosis

1971 ◽  
Vol 29 ◽  
pp. 576-577
Author(s):  
F. G. Zaki ◽  
E. Detzi ◽  
C. H. Keysser
Keyword(s):  
Early Development ◽  
Hepatic Necrosis ◽  
Screening Tests ◽  
Dense Matrix ◽  
Sprague Dawley ◽  
Electron Microscopic ◽  
Drug Induced ◽  
Hepatocellular Damage ◽  
Sprague Dawley Rats ◽  
Microscopic Studies

This study represents the first in a series of investigations carried out to elucidate the mechanism(s) of early hepatocellular damage induced by drugs and other related compounds. During screening tests of CNS-active compounds in rats, it has been found that daily oral administration of one of these compounds at a dose level of 40 mg. per kg. of body weight induced diffuse massive hepatic necrosis within 7 weeks in Charles River Sprague Dawley rats of both sexes. Partial hepatectomy enhanced the development of this peculiar type of necrosis (3 weeks instead of 7) while treatment with phenobarbital prior to the administration of the drug delayed the appearance of necrosis but did not reduce its severity.Electron microscopic studies revealed that early development of this liver injury (2 days after the administration of the drug) appeared in the form of small dark osmiophilic vesicles located around the bile canaliculi of all hepatocytes (Fig. 1). These structures differed from the regular microbodies or the pericanalicular multivesicular bodies. They first appeared regularly rounded with electron dense matrix bound with a single membrane. After one week on the drug, these vesicles appeared vacuolated and resembled autophagosomes which soon developed whorls of concentric lamellae or cisterns characteristic of lysosomes (Fig. 2). These lysosomes were found, later on, scattered all over the hepatocytes.

Ultrastructural investigation of spontaneous pituitary gonadotroph cell adenomas in aging Sprague-Dawley rats

1983 ◽  
Vol 41 ◽  
pp. 702-703
Author(s):  
D. J. McComb ◽  
J. Beri ◽  
F. Zak ◽  
K. Kovacs
Keyword(s):  
Electron Microscopy ◽  
Animal Model ◽  
Epoxy Resin ◽  
Immunoelectron Microscopy ◽  
Tumor Type ◽  
Gonadal Function ◽  
Sprague Dawley ◽  
Male And Female ◽  
Reticulin Fibers ◽  
Sprague Dawley Rats

Gonadotroph cell adenomas of the pituitary are infrequent in human patients and are not invariably associated with altered gonadal function. To date, no animal model of this tumor type exists. Herein, we describe spontaneous gonadotroph cell adenomas in old male and female Sprague-Dawley rats by histology, immunocytology and electron microscopy.The material consisted of the pituitaries of 27 male and 38 female Sprague Dawley rats, all 26 months of age or older, removed at routine autopsy. Sections of formal in-fixed, paraffin-embedded tissue were stained with hematoxylin-phloxine-saffron (HPS), the PAS method and the Gordon-Sweet technique for the demonstration of reticulin fibers. For immunostaining, sections were exposed to anti-rat β-LH, anti-ratβ-TSH, anti-rat PRL, anti-rat GH and anti-rat ACTH 1-39. For electron microscopy, tissue was fixed in 2.5% glutaraldehyde, postfixed in 1% OsO4 and embedded in epoxy-resin. Tissue fixed in 10% formalin, embedded in epoxy resin without osmification, was used for immunoelectron microscopy.

Sign in / Sign up

Export Citation Format

Share Document