scholarly journals Impact of Dietary Protein on Polyunsaturated Fatty Acid Desaturation in Rats Fed Diets Rich in α-Linolenic Acid

1993 ◽  
Vol 57 (1) ◽  
pp. 61-64 ◽  
Author(s):  
Akira Ikeda ◽  
Kazunori Koba ◽  
Michihiro Sugano
Keyword(s):  
Fatty Acid ◽  
Linolenic Acid ◽  
Polyunsaturated Fatty Acid ◽  
Dietary Protein ◽  
Fatty Acid Desaturation

scholarly journals Dietary Fat and Polyunsaturated Fatty Acid Intakes during Childhood Are Prospectively Associated with Puberty Timing Independent of Dietary Protein

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 275
Author(s):  
Yujie Xu ◽  
Jingyuan Xiong ◽  
Wanke Gao ◽  
Xiaoyu Wang ◽  
Shufang Shan ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Dietary Fat ◽  
Dietary Protein ◽  
Protein Intake ◽  
Age At Menarche ◽  
Dietary Protein Intake ◽  
Dietary Intakes ◽  
Nutrition Survey ◽  
Total Fat

Dietary fat and fat quality have been inconsistently associated with puberty timing. The aim of this study was to investigate the prospective associations of dietary fat, saturated fatty acid (SFA), polyunsaturated fatty acid (PUFA), and monounsaturated fatty acid (MUFA) with puberty timing. Using longitudinal data from China Health and Nutrition Survey (CHNS) and Southwest China Childhood Nutrition and Growth (SCCNG) Study, we analyzed dietary data, anthropometric measurements, and potential confounders. Dietary intakes were assessed by 3-day 24-h recalls. Age at Tanner stage 2 for breast/genital development (B2/G2) and age at menarche/voice break (M/VB) were used as puberty development markers. Cox proportional hazard regression models were used to estimate the relevance of dietary intake of total fat, SFA, PUFA, and MUFA on puberty timing. Among 3425 girls and 2495 boys, children with higher intakes of total fat and PUFA were more likely to reach their B2/G2 or M/VB at an earlier age. Associations were not attenuated on additional adjustment for childhood dietary protein intake. However, higher intakes of SFA or MUFA were not independently associated with puberty development. A higher intake of dietary fat and PUFA in prepuberty was associated with earlier puberty timing, which was independent of dietary protein intake.

Modulation of the atrial specific Kv1.5 channel by the n-3 polyunsaturated fatty acid, α-linolenic acid

2008 ◽  
Vol 44 (2) ◽  
pp. 323-335 ◽  
Author(s):  
Miriam Guizy ◽  
Miren David ◽  
Cristina Arias ◽  
Lian Zhang ◽  
Montserrat Cofán ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Linolenic Acid ◽  
Polyunsaturated Fatty Acid

scholarly journals Dietary Protein Level Interacts With  -3 Polyunsaturated Fatty Acid Deficiency to Induce Hypertension

2010 ◽  
Vol 23 (2) ◽  
pp. 125-128 ◽  
Author(s):  
D. P. Begg ◽  
A. J. Sinclair ◽  
L. A. Stahl ◽  
M. L. Garg ◽  
M. Jois ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Polyunsaturated Fatty Acid ◽  
Dietary Protein ◽  
Protein Level ◽  
Dietary Protein Level ◽  
Acid Deficiency ◽  
Fatty Acid Deficiency

scholarly journals The impact of plasma membrane lipid composition on flagella-mediated adhesion of enterohemorrhagic Escherichia coli

2020 ◽  
Author(s):  
Hélène Cazzola ◽  
Laurine Lemaire ◽  
Sébastien Acket ◽  
Elise Prost ◽  
Luminita Duma ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Plasma Membrane ◽  
Fatty Acid ◽  
Linolenic Acid ◽  
Lipid Rafts ◽  
Cell Lines ◽  
Polyunsaturated Fatty Acid ◽  
Bacterial Adhesion ◽  
Human Pathogen ◽  
The Impact

AbstractEnterohemorrhagic Escherichia coli (EHEC) O157:H7 is a major cause of foodborne gastrointestinal illness. The adhesion of EHEC on host tissues is the first step enabling bacterial colonization. Adhesins like fimbriae and flagella mediate this mechanism. Here, we studied the interaction of the bacterial flagellum with the host cell’s plasma membrane using Giant Unilamellar Vesicles (GUVs) as a biologically relevant model. Cultured cell lines contain many different molecular components including proteins and glycoproteins. In contrast, with GUVs we can characterize the bacterial mode of interaction solely with a defined lipid part of the cell membrane. Bacterial adhesion on GUVs was dependent on the presence of the flagellar filament and its motility. By testing different phospholipid head groups, the nature of the fatty acid chains or the liposome curvature, we found that lipid packing is a key parameter to enable bacterial adhesion. Using HT-29 cells grown in the presence of polyunsaturated fatty acid (α-linolenic acid) or saturated fatty acid (palmitic acid), we found that α-linolenic acid reduced adhesion of wild type EHEC but not of a non-flagellated mutant. Finally, our results reveal that the presence of flagella is advantageous for the bacteria to bind to lipid rafts. We speculate that polyunsaturated fatty acids prevent flagellar adhesion on membrane bilayers and play a clear role for optimal host colonization. Flagella-mediated adhesion to plasma membranes has broad implications to host-pathogen interactions.ImportanceBacterial adhesion is a crucial step to allow bacteria to colonize their hosts, invade tissues and form biofilm. Enterohemorrhagic E. coli O157:H7 is a human pathogen and the causative agent of diarrhea and hemorrhagic colitis. Here, we use biomimetic membrane models and cell lines to decipher the impact of lipid content of the plasma membrane on enterohemorrhagic E. coli flagella-mediated adhesion. Our findings provide evidence that polyunsaturated fatty acid (α-linolenic acid) inhibits E. coli flagella adhesion to the plasma membrane in a mechanism separate from its antimicrobial and anti-inflammatory functions. In addition, we confirm that cholesterol-enriched lipid microdomains, often called lipid rafts are important in bacterial adhesion. These findings significantly strengthen plasma membrane adhesion via bacterial flagella in an important human pathogen. This mechanism represents a promising target for the development of novel anti-adhesion therapies.

Sign in / Sign up

Export Citation Format

Share Document