The Hypocholesterolemic Action ofLentinus edodesIs Evoked through Alteration of Phospholipid Composition of Liver Microsomes in Rats

1993 ◽  
Vol 57 (11) ◽  
pp. 1983-1985 ◽  
Author(s):  
Kimio Sugiyama ◽  
Toshiyuki Akachi ◽  
Akihiro Yamakawa
Keyword(s):  
Liver Microsomes ◽  
Phospholipid Composition ◽  
Hypocholesterolemic Action

scholarly journals BIOGENESIS OF ENDOPLASMIC RETICULUM MEMBRANES

1966 ◽  
Vol 30 (1) ◽  
pp. 97-117 ◽  
Author(s):  
Gustav Dallner ◽  
Philip Siekevitz ◽  
George E. Palade
Keyword(s):  
Fatty Acid ◽  
Cytochrome C ◽  
Reductase Activity ◽  
Maternal Diet ◽  
Liver Microsomes ◽  
Phospholipid Composition ◽  
Rat Hepatocytes ◽  
Adult Rats ◽  
Original Activity ◽  
Cytochrome C Reductase

The constitutive enzymes of microsomal membranes were investigated during a period of rapid ER development (from 3 days before to 8 days after birth) in rat hepatocytes. The activities studied (electron transport enzymes and phosphatases) appear at different times and increase at different rates. The increase in the enzyme activities tested was inhibited by Actinomycin D and puromycin. G-6-Pase and NADPH-cytochrome c reductase activities appeared first in the rough microsomes, and subsequently in smooth microsomes, eventually reaching a uniform concentration as in adult liver. The evidence suggests that the enzymes are synthesized in the rough part, then transferred to the smooth part, of the ER. Changes in the fat supplement of the maternal diet brought about changes in the fatty acid composition of microsomal phospholipids but did not influence the enzymic pattern of the suckling. Microsomes from 8-day-old and adult rats lose 95% of PLP and 80% of NADH-cytochrome c reductase activity after acetone-H2O (10:1) extraction. However, one-half the original activity could be regained by adding back phospholipid micelles prepared from purified phospholipid, or from lipid extracts of heart mitochondria, or of liver microsomes of 8-day or adult rats, thus demonstrating an activation of the enzyme by nonspecific phospholipid. The results suggest that during development the enzymic pattern is not influenced by the fatty acid or phospholipid composition of ER membranes.

Sex difference in the phospholipid composition of rat liver microsomes

1975 ◽  
Vol 24 (2) ◽  
pp. 301-303 ◽  
Author(s):  
Helen Belina ◽  
Stanley D. Cooper ◽  
Rose Farkas ◽  
George Feuer
Keyword(s):  
Sex Difference ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Phospholipid Composition ◽  
Rat Liver Microsomes

Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes

Xenobiotica ◽  
2009 ◽  
Vol 00 (00) ◽  
pp. 090901052053001-8
Author(s):  
K. Murai ◽  
H. Yamazaki ◽  
K. Nakagawa ◽  
R. Kawai ◽  
T. Kamataki
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cancer Drug ◽  
Anti Cancer ◽  
Cytochrome P450 2A6

Selegiline Metabolism and Cytochrome P450 Enzymes:In vitro Study in Human Liver Microsomes*

2000 ◽  
Vol 86 (5) ◽  
pp. 215-221 ◽  
Author(s):  
Paivi Taavitsainen ◽  
Markku Anttila ◽  
Leena Nyman ◽  
Hari Karnani ◽  
Jarmo S. Salonen ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Vitro Study

Platelet Functions in Relation to Dietary Fats in Farmers from two Regions of France

1978 ◽  
Vol 40 (02) ◽  
pp. 518-531 ◽  
Author(s):  
S Renaud ◽  
E Dumont ◽  
F Godsey ◽  
A Suplisson ◽  
C Thevenon
Keyword(s):  
Platelet Aggregation ◽  
Platelet Rich Plasma ◽  
Plasma Cholesterol ◽  
Phospholipid Composition ◽  
Saturated Fat ◽  
Phosphatidyl Inositol ◽  
Phosphatidyl Serine ◽  
Dietary Fats ◽  
Platelet Phospholipid ◽  
Platelet Functions

SummaryTo determine whether the long-term feeding of dietary fats affect platelet functions in man, platelet aggregation (to thrombin ADP, collagen, epinephrine) and clotting activity of platelet-rich plasma (PRP), platelet-poor plasma and of washed platelets, were studied in a mobile-laboratory in 44 healthy male farmers (40-45 years) from two French regions Var and Moselle, in relation to lipemia, glycemia, dietary nutriments, and platelet phospholipid composition. In the Moselle subjects, the platelet clotting activity of PRP and of washed platelets, the platelet aggregation to thrombin and ADP, were highly significantly (p <0.001) increased as compared to those of Var, but not the plasma cholesterol, which was identical in the two regions.In Moselle, the intake of total calories, total lipids and saturated fats was higher than in the Var.However, it was only with the saturated fat intake (mostly stearic acid) that the platelet clotting activity (p <0.01) and the platelet aggregation (p <0.001) were highly significantly correlated. The platelet clotting activity was also significantly (p <0.001) correlated with the fatty acid composition of the platelet phospholipid fractions phosphatidyl serine + phosphatidyl inositol.

Proceedings: Changes in the phospholipid composition of spermatozoa in the reproductive tract of the ram

Reproduction ◽  
1974 ◽  
Vol 36 (2) ◽  
pp. 442-443 ◽  
Author(s):  
A Poulos ◽  
P. Brown ◽  
R Cox ◽  
I. White
Keyword(s):  
Reproductive Tract ◽  
Phospholipid Composition
Sign in / Sign up

Export Citation Format

Share Document