scholarly journals Synergistic Antioxidative Effects of Porphyrin Derivatives with α-Tocopherol and Ascorbic Acid

1993 ◽  
Vol 57 (10) ◽  
pp. 1753-1754 ◽  
Author(s):  
Antonius Herry Cahyana ◽  
Yoshihiro Shuto ◽  
Yoshiro Kinoshita
Keyword(s):  
Ascorbic Acid ◽  
Porphyrin Derivatives ◽  
Antioxidative Effects

scholarly journals Antioxidative Effects of Salts on the Oxidation of L-Ascorbic Acid

1967 ◽  
Vol 41 (2) ◽  
pp. 77-78 ◽  
Author(s):  
Setsuro MATSUSHITA ◽  
Nobuko IWAMI ◽  
Yuki NITTA
Keyword(s):  
Ascorbic Acid ◽  
Antioxidative Effects

scholarly journals Synthesis Of PEG Coated Ascorbic Acid Functionalized Silver Nanoparticles and Determining its Antioxidant Activity

2019 ◽  
Vol 8 (4S2) ◽  
pp. 741-744
Keyword(s):  
Antioxidant Activity ◽  
Silver Nanoparticles ◽  
Ascorbic Acid ◽  
Nanoparticle Synthesis ◽  
Drug Carriers ◽  
Functionalized Nanoparticles ◽  
Antioxidative Effects ◽  
Uv Visible ◽  
Average Size ◽  
Scanning Electron

Silver nanoparticles are extensively being studied for various applications in different fields. Functionalized silver nanoparticles are now being used as drug carriers. Ascorbic acid (Vitamin C) is a well-known antioxidant which has been reported to have various beneficial properties to humans. Here we have synthesized silver nanoparticles functionalized with ascorbic acid. The functionalized nanoparticles were further coated with PEG. The nanoparticle synthesis was characterized using UV-Visible spectral analysis, XRD, FTIR and Scanning electron microscope. The average size of the nanoparticle was found to be 24 nm. The synthesized nanoparticle was found to possess antioxidative effects.

scholarly journals Antioxidative Effects of Ascorbic Acid and Astaxanthin on ARPE-19 Cells in an Oxidative Stress Model

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 833 ◽  
Author(s):  
Sanghyeon Oh ◽  
Young Joo Kim ◽  
Eun Kyoung Lee ◽  
Sung Wook Park ◽  
Hyeong Gon Yu
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Cell Viability ◽  
Lethal Dose ◽  
Ultraviolet B ◽  
Stress Model ◽  
Antioxidative Effect ◽  
Pathogenic Factors ◽  
Intracellular Ros ◽  
Antioxidative Effects

Oxidative stress has been implicated as critical pathogenic factors contributing to the etiology of diabetic retinopathy and other retinal diseases. This study investigated antioxidative effect of ascorbic acid and astaxanthin on ARPE-19 cells within an oxidative stress model induced by common biological sources of reactive oxygen species (ROS). Hydrogen peroxide (H2O2) at concentrations of 0.1–0.8 mM and 20–100 mJ/cm2 of ultraviolet B (UVB) were treated to ARPE-19 cells. Cell viability and intracellular ROS level changes were measured. With the sublethal and lethal dose of each inducers, 0–750 μM of ascorbic acid and 0–40 μM of astaxanthin were treated to examine antioxidative effect on the model. Ascorbic acid at concentrations of 500 and 750 μM increased the cell viability not only in the UVB model but also in the H2O2 model, but 20 and 40 μM of astaxanthin only did so in the UVB model. The combination of ascorbic acid and astaxanthin showed better antioxidative effect compared to each drug alone, suggesting a synergistic effect.

scholarly journals Antioxidative effects of supplementing linseed oil-enriched diets with α-tocopherol, ascorbic acid, selenium, or their combination on carcass and meat quality in broilers

2019 ◽  
Vol 98 (12) ◽  
pp. 6733-6741 ◽  
Author(s):  
J. Leskovec ◽  
A. Levart ◽  
L. Perić ◽  
M. Đukić Stojčić ◽  
V. Tomović ◽  
...  
Keyword(s):  
Ascorbic Acid ◽  
Meat Quality ◽  
Linseed Oil ◽  
Antioxidative Effects

Mitigation of arsenic-mediated renal oxidative stress in rat by Pleurotus florida lectin

2010 ◽  
Vol 30 (8) ◽  
pp. 940-951 ◽  
Author(s):  
Asit Kumar Bera ◽  
Tanmoy Rana ◽  
Subhashree Das ◽  
Debasis Bhattacharya ◽  
Diganta Pan ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Ascorbic Acid ◽  
Superoxide Dismutase ◽  
Body Weight ◽  
No Production ◽  
Dependent Manner ◽  
Oral Supplementation ◽  
Pleurotus Florida ◽  
Antioxidative Effects ◽  
Mushroom Lectin

Oyster mushroom, Pleurotus florida is regarded as one of the popular food with biopharmaceutical properties. Here, the study aimed to investigate the antioxidative effects of mushroom (Pleurotus florida) lectin against arsenic-induced nephrotoxicity in rats. Animals were divided into four groups; Group 1 was control. Groups 2, 3 and 4 were exposed to arsenic (20 parts per million [ppm] in drinking water), arsenic plus oral supplementation of ascorbic acid (25 mg/kg body weight) and arsenic plus oral supplementation of mushroom lectin (150 mg/kg body weight) respectively. Both ascorbic acid and mushroom lectin prevented the arsenic-mediated growth retardation and normalized the elevated kidney weight. Disrupted activities of superoxide dismutase (SOD) and catalase (CAT) and enhanced lipid peroxidation (LPO), protein carbonyl (PC) and nitric oxides (NO) production in kidney caused by arsenic could also be maintained towards normalcy by supplementation of mushroom lectin and ascorbic acid. These antioxidative effects were exhibited in a time-dependant manner. Further, arsenic-mediated down-regulation of messenger RNA (mRNA) expression of superoxide dismutase 2 (SOD2) gene was obstructed by these agents. Thus it was found that mushroom lectin reversed the effect of arsenic-mediated oxidative stress in a time-dependent manner.

Comparative Study of Ascorbic Acid Levels in Gastric Secretion, Blood, Urine and Saliva

1951 ◽  
Vol 18 (2) ◽  
pp. 224-229 ◽  
Author(s):  
Joseph T. Freeman ◽  
Roberta Hafkesbring
Keyword(s):  
Ascorbic Acid ◽  
Gastric Secretion ◽  
Comparative Study

Sorbitol enhances the physicochemical stability of B12 vitamers

2020 ◽  
Vol 90 (5-6) ◽  
pp. 439-447 ◽  
Author(s):  
Andrew Hadinata Lie ◽  
Maria V Chandra-Hioe ◽  
Jayashree Arcot
Keyword(s):  
Ascorbic Acid ◽  
Uv Light ◽  
Heat Exposure ◽  
Water Soluble ◽  
Uv Exposure ◽  
Physicochemical Stability ◽  
Before And After ◽  
The Stability

Abstract. The stability of B12 vitamers is affected by interaction with other water-soluble vitamins, UV light, heat, and pH. This study compared the degradation losses in cyanocobalamin, hydroxocobalamin and methylcobalamin due to the physicochemical exposure before and after the addition of sorbitol. The degradation losses of cyanocobalamin in the presence of increasing concentrations of thiamin and niacin ranged between 6%-13% and added sorbitol significantly prevented the loss of cyanocobalamin (p<0.05). Hydroxocobalamin and methylcobalamin exhibited degradation losses ranging from 24%–26% and 48%–76%, respectively; added sorbitol significantly minimised the loss to 10% and 20%, respectively (p < 0.05). Methylcobalamin was the most susceptible to degradation when co-existing with ascorbic acid, followed by hydroxocobalamin and cyanocobalamin. The presence of ascorbic acid caused the greatest degradation loss in methylcobalamin (70%-76%), which was minimised to 16% with added sorbitol (p < 0.05). Heat exposure (100 °C, 60 minutes) caused a greater loss of cyanocobalamin (38%) than UV exposure (4%). However, degradation losses in hydroxocobalamin and methylcobalamin due to UV and heat exposures were comparable (>30%). At pH 3, methylcobalamin was the most unstable showing 79% degradation loss, which was down to 12% after sorbitol was added (p < 0.05). The losses of cyanocobalamin at pH 3 and pH 9 (~15%) were prevented by adding sorbitol. Addition of sorbitol to hydroxocobalamin at pH 3 and pH 9 reduced the loss by only 6%. The results showed that cyanocobalamin was the most stable, followed by hydroxocobalamin and methylcobalamin. Added sorbitol was sufficient to significantly enhance the stability of cobalamins against degradative agents and conditions.

Inhibition of Pro-Inflammatory Cytokine Secretion by Select Antioxidants in Human Coronary Artery Endothelial Cells

2020 ◽  
Vol 90 (1-2) ◽  
pp. 103-112 ◽  
Author(s):  
Michael J. Haas ◽  
Marilu Jurado-Flores ◽  
Ramadan Hammoud ◽  
Victoria Feng ◽  
Krista Gonzales ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Ascorbic Acid ◽  
Coronary Artery ◽  
Inflammatory Cytokines ◽  
Inflammatory Cytokine ◽  
Culture Media ◽  
Cytokine Secretion ◽  
Human Coronary Artery ◽  
Tnf Α ◽  
Pro Inflammatory Cytokines

Abstract. Inflammatory and oxidative stress in endothelial cells are implicated in the pathogenesis of premature atherosclerosis in diabetes. To determine whether high-dextrose concentrations induce the expression of pro-inflammatory cytokines, human coronary artery endothelial cells (HCAEC) were exposed to either 5.5 or 27.5 mM dextrose for 24-hours and interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor α (TNF α) levels were measured by enzyme immunoassays. To determine the effect of antioxidants on inflammatory cytokine secretion, cells were also treated with α-tocopherol, ascorbic acid, and the glutathione peroxidase mimetic ebselen. Only the concentration of IL-1β in culture media from cells exposed to 27.5 mM dextrose increased relative to cells maintained in 5.5 mM dextrose. Treatment with α-tocopherol (10, 100, and 1,000 μM) and ascorbic acid (15, 150, and 1,500 μM) at the same time that the dextrose was added reduced IL-1β, IL-6, and IL-8 levels in culture media from cells maintained at 5.5 mM dextrose but had no effect on IL-1β, IL-6, and IL-8 levels in cells exposed to 27.5 mM dextrose. However, ebselen treatment reduced IL-1β, IL-6, and IL-8 levels in cells maintained in either 5.5 or 27.5 mM dextrose. IL-2 and TNF α concentrations in culture media were below the limit of detection under all experimental conditions studied suggesting that these cells may not synthesize detectable quantities of these cytokines. These results suggest that dextrose at certain concentrations may increase IL-1β levels and that antioxidants have differential effects on suppressing the secretion of pro-inflammatory cytokines in HCAEC.

Sign in / Sign up

Export Citation Format

Share Document