Preferential Suppression of Delayed-type Hypersensitivity by L-156,602, a C5a Receptor Antagonist

1992 ◽  
Vol 56 (10) ◽  
pp. 1686-1689 ◽  
Author(s):  
Ryohei F. Tsuji ◽  
Masakazu Uramoto ◽  
Hiroyuki Koshino ◽  
Noriko M. Tsuji ◽  
Junji Magae ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Delayed Type Hypersensitivity ◽  
C5a Receptor

scholarly journals A New Small Molecule C5a Receptor Antagonist Inhibits the Reverse-Passive Arthus Reaction and Endotoxic Shock in Rats

2000 ◽  
Vol 164 (12) ◽  
pp. 6560-6565 ◽  
Author(s):  
Anna J. Strachan ◽  
Trent M. Woodruff ◽  
Gerald Haaima ◽  
David P. Fairlie ◽  
Stephen M. Taylor
Keyword(s):  
Receptor Antagonist ◽  
Small Molecule ◽  
Endotoxic Shock ◽  
Arthus Reaction ◽  
C5a Receptor

scholarly journals A Potent Human C5a Receptor Antagonist Protects against Disease Pathology in a Rat Model of Inflammatory Bowel Disease

2003 ◽  
Vol 171 (10) ◽  
pp. 5514-5520 ◽  
Author(s):  
Trent M. Woodruff ◽  
Thiruma V. Arumugam ◽  
Ian A. Shiels ◽  
Robert C. Reid ◽  
David P. Fairlie ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Receptor Antagonist ◽  
Rat Model ◽  
Bowel Disease ◽  
C5a Receptor ◽  
Inflammatory Bowel

Blockade of the Complement C5a Receptor Reduces Incisional Allodynia, Edema, and Cytokine Expression

2006 ◽  
Vol 104 (6) ◽  
pp. 1274-1282 ◽  
Author(s):  
J David Clark ◽  
Yanli Qiao ◽  
Xiangqi Li ◽  
Xiaoyou Shi ◽  
Martin S. Angst ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Complement System ◽  
Messenger Rna ◽  
Receptor Expression ◽  
Daily Injection ◽  
Edema Formation ◽  
C5a Receptor ◽  
Surgical Incisions ◽  
Complement C5a ◽  
The Complement System

Background Activation of the complement system is one component of the inflammatory response. Various components of the complement system participate in killing foreign organisms, recruiting immune cells, enhancing edema, and stimulating cytokine formation. Complement-mediated enhancement of the inflammation surrounding surgical incisions may increase pain. Methods In these studies, the authors used a murine hind paw incisional model to study the role of the complement C5a receptor in supporting incisional inflammation. At baseline and at various time points after incision, they measured the effects of a highly selective C5a receptor antagonist on nociceptive thresholds, edema formation, and cytokine production in the skin surrounding the incision. They also measured changes in C5a receptor expression near the incisions. Results The once-daily injection of the C5a receptor antagonist AcF-[OPdChaWR] reduced mechanical allodynia and edema in the incised hind paw. A multiplexed cytokine assay revealed that 8 of the 18 cytokines examined showed significant increases in skin tissue abundance after incision. Distinct time courses for the patterns of elevation were seen, though some degree of resolution occurred for all cytokines within 96 h. For 7 of these 8 cytokines, the C5a receptor antagonist reduced the enhancement of expression. In addition, the authors found that the C5a receptor messenger RNA level increased 15-fold in the skin surrounding the incisions within 24 h and then slowly declined. Conclusions The tissue directly surrounding incisions in mouse hind paws undergoes large changes in the content of specific cytokines in addition to demonstrating edema and nociceptive sensitization. By blocking the receptor for one component of the complement system, C5a, all of these changes can be reduced. Complement receptor inhibitors may constitute a novel group of compounds useful in reducing the pain and swelling of surgical incisions.

scholarly journals C5a Receptor Antagonist Protects Mice from Uropathogenic Escherichia Coli-Induced Kidney Infection

2014 ◽  
Vol 17 (7) ◽  
pp. A811
Author(s):  
T. Zhang ◽  
K.Y. Wu ◽  
Z.Y. Duan ◽  
Y. Lin ◽  
B.S. Gui ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Receptor Antagonist ◽  
Uropathogenic Escherichia Coli ◽  
C5a Receptor

scholarly journals A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats

2003 ◽  
Vol 63 (1) ◽  
pp. 134-142 ◽  
Author(s):  
Thiruma V. Arumugam ◽  
Ian A. Shiels ◽  
Anna J. Strachan ◽  
Giovani Abbenante ◽  
David P. Fairlie ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Reperfusion Injury ◽  
Small Molecule ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
C5a Receptor

Protective effects of a potent c5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats

2004 ◽  
Vol 116 (1) ◽  
pp. 81-90 ◽  
Author(s):  
Trent M Woodruff ◽  
Thiruma V Arumugam ◽  
Ian A Shiels ◽  
Robert C Reid ◽  
David P Fairlie ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
Ischemia Reperfusion ◽  
Limb Ischemia ◽  
Acute Limb Ischemia ◽  
Protective Effects ◽  
C5a Receptor

scholarly journals RP S19 C-terminal peptide trimer acts as a C5a receptor antagonist

2016 ◽  
Vol 7 ◽  
pp. 70-76
Author(s):  
Hiroshi Nishiura ◽  
Toru Kawakami ◽  
Mutsuki Kawabe ◽  
Nahoko Kato-Kogoe ◽  
Naoko Yamada ◽  
...  
Keyword(s):  
Receptor Antagonist ◽  
C5a Receptor
Sign in / Sign up

Export Citation Format

Share Document