Asymmetric Total Synthesis of 6-Tuliposide B and Its Biological Activities against Tulip Pathogenic Fungi

2011 ◽  
Vol 75 (4) ◽  
pp. 718-722 ◽  
Author(s):  
Kengo SHIGETOMI ◽  
Shoko OMOTO ◽  
Yasuo KATO ◽  
Makoto UBUKATA
Keyword(s):  
Total Synthesis ◽  
Biological Activities ◽  
Pathogenic Fungi ◽  
Asymmetric Total Synthesis

Biomimetic approach toward the stereoselective synthesis of acetogenins

2003 ◽  
Vol 75 (2-3) ◽  
pp. 259-264 ◽  
Author(s):  
R. V. A. Orru ◽  
Bas Groenendaal ◽  
J. van Heyst ◽  
Mark Hunting ◽  
C. Wesseling ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Broad Spectrum ◽  
Stereoselective Synthesis ◽  
Biological Activities ◽  
Building Blocks ◽  
Hydrocarbon Chain ◽  
Tropical Trees ◽  
Asymmetric Total Synthesis ◽  
Biomimetic Approach

Acetogenins isolated from the Annonaceae family of tropical trees have drawn considerable attention owing to their broad spectrum of biological activities. They are structurally characterized by the presence of one to three tetrahydrofuran rings in the center of a long (partly hydroxylated) hydrocarbon chain that ends in a (functionalized) butenolide moiety. Here we describe some of our results toward the first asymmetric total synthesis of cis-gigantrionenin, a principal acetogenin. In this approach, an enzyme-catalyzed epoxide hydrolysis and an enzyme-triggered double cyclization are crucial and give stereoselective access to essential chiral building blocks.

ChemInform Abstract: ASYMMETRIC TOTAL SYNTHESIS OF 11α-HYDROXYPROGESTERONE VIA A BIOMIMETIC POLYENE CYCLIZATION

1978 ◽  
Vol 9 (12) ◽  
Author(s):  
W. S. JOHNSON ◽  
R. S. BRINKMEYER ◽  
V. M. KAPOOR ◽  
T. M. YARNELL
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis

Asymmetric Total Synthesis of Norzoanthamine

2021 ◽  
Author(s):  
Zhengyuan Xin ◽  
Hui Wang ◽  
Haibing He ◽  
Xiaoli Zhao ◽  
Shuanhu Gao
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis

scholarly journals Asymmetric Total Synthesis of Hetiamacins A–F

ACS Omega ◽  
2021 ◽  
Vol 6 (12) ◽  
pp. 8239-8245
Author(s):  
Gang Wu ◽  
Ting Wang ◽  
Zhongke Jiang ◽  
Shaowei Liu ◽  
Chenghang Sun
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis

scholarly journals Xylochemical Synthesis and Biological Evaluation of Shancigusin C and Bletistrin G

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3224
Author(s):  
Leander Geske ◽  
Ulrich Kauhl ◽  
Mohamed E. M. Saeed ◽  
Anja Schüffler ◽  
Eckhard Thines ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Biological Activities ◽  
Biological Evaluation ◽  
Aromatic Substitution ◽  
Substitution Reactions ◽  
Total Syntheses ◽  
Wittig Olefination ◽  
Starting Point ◽  
Perkin Reaction ◽  
Synthesis And Biological Evaluation

The biological activities of shancigusin C (1) and bletistrin G (2), natural products isolated from orchids, are reported along with their first total syntheses. The total synthesis of shancigusin C (1) was conducted by employing the Perkin reaction to forge the central stilbene core, whereas the synthesis of bletistrin G (2) was achieved by the Wittig olefination followed by several regioselective aromatic substitution reactions. Both syntheses were completed by applying only renewable starting materials according to the principles of xylochemistry. The cytotoxic properties of shancigusin C (1) and bletistrin G (2) against tumor cells suggest suitability as a starting point for further structural variation.

Asymmetric Total Synthesis and Determination of the Absolute Configuration of (+)-Srilankenyne via Sequence-Sensitive Halogenations Guided by Conformational Analysis

2021 ◽  
Vol 23 (4) ◽  
pp. 1321-1326
Author(s):  
Hongjun Jang ◽  
Soo Yeon Kwak ◽  
Dongjoo Lee ◽  
Juan V. Alegre-Requena ◽  
Hyoungsu Kim ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Conformational Analysis ◽  
Absolute Configuration ◽  
Asymmetric Total Synthesis ◽  
The Absolute

Asymmetric Total Synthesis of Amphirionin-2

2021 ◽  
Author(s):  
Dhiman Saha ◽  
Gour Hari Mandal ◽  
Rajib Kumar Goswami
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis

Asymmetric Total Synthesis of ent-Tetrahydrolipstatin from an Epoxy Alkenol

Synlett ◽  
2012 ◽  
Vol 23 (12) ◽  
pp. 1832-1834 ◽  
Author(s):  
Jinsung Tae ◽  
Hyemi Kim ◽  
Kyeonghwan Choi
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis

Asymmetric Total Synthesis of Sarpagine and Koumine Alkaloids

2021 ◽  
Author(s):  
Min Zhang ◽  
Zhao Yang ◽  
Qiuyuan Tan ◽  
Yan Jiang ◽  
Jiaojiao Yang ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Asymmetric Total Synthesis
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