scholarly journals Genistein Induced Apoptotic Cell Death in Adult T-Cell Leukemia Cells through Estrogen Receptors

2010 ◽  
Vol 74 (10) ◽  
pp. 2113-2115 ◽  
Author(s):  
Masao YAMASAKI ◽  
Ayako MUKAI ◽  
Masayo OHBA ◽  
Yoshihiro MINE ◽  
Yoichi SAKAKIBARA ◽  
...  
Keyword(s):  
Cell Death ◽  
T Cell ◽  
Estrogen Receptors ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Leukemia Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

Genistein induces apoptotic cell death associated with inhibition of the NF-κB pathway in adult T-cell leukemia cells

2013 ◽  
Vol 37 (7) ◽  
pp. 742-747 ◽  
Author(s):  
Masao Yamasaki ◽  
Yoshihiro Mine ◽  
Misato Nishimura ◽  
Satoshi Fujita ◽  
Yoichi Sakakibara ◽  
...  
Keyword(s):  
Cell Death ◽  
T Cell ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Leukemia Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

scholarly journals Sensitive detection and apoptotic cell death induction of adult T-cell leukemia/lymphoma (ATL) cells with photodynamic actions

Retrovirology ◽  
2014 ◽  
Vol 11 (S1) ◽  
Author(s):  
Takashi Oka ◽  
Hirofumi Fujita ◽  
Lamia Abd Al-Kader ◽  
Ichiro Murakami ◽  
Atae Utsunomiya ◽  
...  
Keyword(s):  
Cell Death ◽  
T Cell ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Sensitive Detection ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

scholarly journals APO-1-induced apoptosis of leukemia cells from patients with adult T- cell leukemia

Blood ◽  
1993 ◽  
Vol 81 (11) ◽  
pp. 2972-2977 ◽  
Author(s):  
KM Debatin ◽  
CK Goldman ◽  
TA Waldmann ◽  
PH Krammer
Keyword(s):  
Cell Death ◽  
T Cell ◽  
Cell Lines ◽  
Ex Vivo ◽  
Apoptotic Cell ◽  
Leukemic Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Induction Of Apoptosis

Abstract The 48-Kd cell-surface protein APO-1 is a new member of the nerve growth factor (NGF)/tumor necrosis factor (TNF) receptor superfamily. APO-1 is expressed on various cells, including activated T and B cells and some lymphoid and nonlymphoid cell lines. Triggering of APO-1 by the monoclonal antibody anti-APO-1 induces programmed cell death (apoptosis) in APO-1-expressing cells. APO-1 is also present on T-cell lines derived from patients with adult T-cell leukemia (ATL). Therefore, we investigated APO-1 expression and APO-1-mediated induction of apoptosis ex vivo in cells from patients with ATL. Fresh leukemic cells from nine patients with ATL were assayed for APO-1 expression by two-color immunofluorescence. The leukemic cells from all patients strongly expressed APO-1. Incubation of ATL cells with anti- APO-1 in vitro inhibited spontaneous and cytokine-mediated DNA synthesis. Furthermore, DNA isolated from cells treated with anti-APO-1 exhibited polynucleosomal DNA fragmentation (DNA ladder) characteristic for apoptotic cell death. The analysis of APO-1-mediated apoptosis may represent a new approach to the study of growth control in lymphoid malignancies. In addition, induction of apoptosis by administration of anti-APO-1 may represent a new therapeutic approach for aggressive T- cell malignancies such as ATL.

scholarly journals Induction of cell death in adult T-cell leukemia cells by a novel IκB kinase inhibitor

Leukemia ◽  
2006 ◽  
Vol 20 (4) ◽  
pp. 590-598 ◽  
Author(s):  
T Sanda ◽  
K Asamitsu ◽  
H Ogura ◽  
S Iida ◽  
A Utsunomiya ◽  
...  
Keyword(s):  
Cell Death ◽  
T Cell ◽  
Kinase Inhibitor ◽  
Leukemia Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Iκb Kinase

scholarly journals APO-1-induced apoptosis of leukemia cells from patients with adult T- cell leukemia

Blood ◽  
1993 ◽  
Vol 81 (11) ◽  
pp. 2972-2977 ◽  
Author(s):  
KM Debatin ◽  
CK Goldman ◽  
TA Waldmann ◽  
PH Krammer
Keyword(s):  
Cell Death ◽  
T Cell ◽  
Cell Lines ◽  
Ex Vivo ◽  
Apoptotic Cell ◽  
Leukemic Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia ◽  
Induction Of Apoptosis

The 48-Kd cell-surface protein APO-1 is a new member of the nerve growth factor (NGF)/tumor necrosis factor (TNF) receptor superfamily. APO-1 is expressed on various cells, including activated T and B cells and some lymphoid and nonlymphoid cell lines. Triggering of APO-1 by the monoclonal antibody anti-APO-1 induces programmed cell death (apoptosis) in APO-1-expressing cells. APO-1 is also present on T-cell lines derived from patients with adult T-cell leukemia (ATL). Therefore, we investigated APO-1 expression and APO-1-mediated induction of apoptosis ex vivo in cells from patients with ATL. Fresh leukemic cells from nine patients with ATL were assayed for APO-1 expression by two-color immunofluorescence. The leukemic cells from all patients strongly expressed APO-1. Incubation of ATL cells with anti- APO-1 in vitro inhibited spontaneous and cytokine-mediated DNA synthesis. Furthermore, DNA isolated from cells treated with anti-APO-1 exhibited polynucleosomal DNA fragmentation (DNA ladder) characteristic for apoptotic cell death. The analysis of APO-1-mediated apoptosis may represent a new approach to the study of growth control in lymphoid malignancies. In addition, induction of apoptosis by administration of anti-APO-1 may represent a new therapeutic approach for aggressive T- cell malignancies such as ATL.

SRT1720 induces SIRT1‐independent cell death in adult T‐cell leukemia/lymphoma

FEBS Journal ◽  
2022 ◽  
Author(s):  
Tomohiro Kozako ◽  
Naho Kato ◽  
Takeo Ohsugi ◽  
Yu‐ichiro Uchida ◽  
Makoto Yoshimitsu ◽  
...  
Keyword(s):  
Cell Death ◽  
T Cell ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

Lack of interleukin-4 mRNA expression in adult T-cell leukemia cells

2009 ◽  
Vol 52 (3) ◽  
pp. 191-192 ◽  
Author(s):  
N. Mori ◽  
F. Shirakawa ◽  
S. Murakami ◽  
S. Oda ◽  
S. Eto
Keyword(s):  
T Cell ◽  
Mrna Expression ◽  
Interleukin 4 ◽  
Leukemia Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Adult T Cell Leukemia

scholarly journals ATF3, an HTLV-1 bZip factor binding protein, promotes proliferation of adult T-cell leukemia cells

Retrovirology ◽  
2011 ◽  
Vol 8 (1) ◽  
pp. 19 ◽  
Author(s):  
Keita Hagiya ◽  
Jun-ichirou Yasunaga ◽  
Yorifumi Satou ◽  
Koichi Ohshima ◽  
Masao Matsuoka
Keyword(s):  
T Cell ◽  
Binding Protein ◽  
Leukemia Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Factor Binding ◽  
Adult T Cell Leukemia ◽  
Bzip Factor

DNA aneuploidy of adult T-cell leukemia cells

1994 ◽  
Vol 18 (2) ◽  
pp. 79-84 ◽  
Author(s):  
Shimeru Kamihira ◽  
Sunao Atogami ◽  
Hisashi Sohda ◽  
Saburo Momita ◽  
Kazuhiro Toryia ◽  
...  
Keyword(s):  
T Cell ◽  
Leukemia Cells ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Dna Aneuploidy ◽  
Adult T Cell Leukemia
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