The Synergy of 6-O-Sulfation andN- or 3-O-Sulfation of Chitosan Is Required for Efficient Inhibition of P-Selectin-Mediated Human Melanoma A375 Cell Adhesion

2010 ◽  
Vol 74 (8) ◽  
pp. 1697-1700 ◽  
Author(s):  
Ruifei WANG ◽  
Jinfeng HUANG ◽  
Min WEI ◽  
Xianlu ZENG
Keyword(s):  
Cell Adhesion ◽  
Human Melanoma ◽  
A375 Cell ◽  
Melanoma A375 Cell

EGCG enhances TRAIL-mediated apoptosis in human melanoma A375 cell line

2009 ◽  
Vol 29 (6) ◽  
pp. 771-775 ◽  
Author(s):  
Qin Shen ◽  
Fen Tian ◽  
Ping Jiang ◽  
Yanqiu Li ◽  
Li Zhang ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Melanoma ◽  
A375 Cell ◽  
Melanoma A375 Cell ◽  
A375 Cell Line

Hypoxia: dual effect on the expression of transferrin receptor in human melanoma A375 cell line

2007 ◽  
Vol 16 (11) ◽  
pp. 899-904 ◽  
Author(s):  
Juan Tao ◽  
Ye-qiang Liu ◽  
Yan Li ◽  
Ji-ling Peng ◽  
Li Li ◽  
...  
Keyword(s):  
Cell Line ◽  
Transferrin Receptor ◽  
Human Melanoma ◽  
Dual Effect ◽  
A375 Cell ◽  
Melanoma A375 Cell ◽  
A375 Cell Line

The interaction between SBA-15 derivative loaded with Ph3Sn(CH2)6OH and human melanoma A375 cell line: uptake and stem phenotype loss

2019 ◽  
Vol 24 (2) ◽  
pp. 223-234 ◽  
Author(s):  
Danijela Maksimović-Ivanić ◽  
Mirna Bulatović ◽  
David Edeler ◽  
Christian Bensing ◽  
Igor Golić ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Melanoma ◽  
A375 Cell ◽  
Melanoma A375 Cell ◽  
A375 Cell Line

scholarly journals Vitamin�C induces human melanoma A375 cell apoptosis via Bax‑ and Bcl‑2‑mediated mitochondrial pathways

2019 ◽  
Author(s):  
Xiao‑Yu Chen ◽  
Ying Chen ◽  
Chuan‑Jun Qu ◽  
Zhao‑Hai Pan ◽  
Yao Qin ◽  
...  
Keyword(s):  
Vitamin C ◽  
Cell Apoptosis ◽  
Human Melanoma ◽  
A375 Cell ◽  
Melanoma A375 Cell

Progression in Human Melanoma Is Accompanied by the Altered Expression of Cell Adhesion Molecules

1993 ◽  
pp. 97-105
Author(s):  
J. P. Johnson ◽  
B. G. Stade ◽  
U. Rothbächer ◽  
S. Stratil ◽  
G. Riethmüller
Keyword(s):  
Cell Adhesion ◽  
Adhesion Molecules ◽  
Cell Adhesion Molecules ◽  
Human Melanoma ◽  
Altered Expression

Kallikrein-related peptidase 7 overexpression in melanoma cells modulates cell adhesion leading to a malignant phenotype

2018 ◽  
Vol 399 (9) ◽  
pp. 1099-1105 ◽  
Author(s):  
Meriem Haddada ◽  
Hend Draoui ◽  
Lydia Deschamps ◽  
Francine Walker ◽  
Tiphaine Delaunay ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Potential Role ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Integrin Expression ◽  
Spheroid Formation ◽  
Malignant Phenotype ◽  
Potential Therapeutic Target ◽  
Β3 Integrin

AbstractWe recently reported that human melanoma cells, but not benign melanocytes, aberrantly express kallikrein-related peptidase 7 (KLK7). Here, we show a KLK7 overexpression-mediated decrease of cell adhesion to extracellular matrix binding proteins, associated with downregulation of α5/β1/αv/β3 integrin expression. We also report an up-regulation of MCAM/CD146 and an increase in spheroid formation of these cells. Our results demonstrate that aberrant KLK7 expression leads to a switch to a more malignant phenotype suggesting a potential role of KLK7 in melanoma invasion. Thus, KLK7 may represent a biomarker for melanoma progression and may be a potential therapeutic target for melanoma.

scholarly journals Optimization of Ultrasonic Flavonoid Extraction from Saussurea involucrate, and the Ability of Flavonoids to Block Melanin Deposition in Human Melanocytes

Molecules ◽  
2020 ◽  
Vol 25 (2) ◽  
pp. 313
Author(s):  
Chun-Yan Dai ◽  
Pei-Ran Liao ◽  
Ming-Zhuo Zhao ◽  
Chao Gong ◽  
Yue Dang ◽  
...  
Keyword(s):  
Extraction Process ◽  
Human Melanoma ◽  
Solvent Ratio ◽  
Melanin Synthesis ◽  
Box Behnken Design ◽  
Good Ability ◽  
Human Melanocytes ◽  
Reducing Activity ◽  
Melanoma A375 Cell ◽  
Scavenging Rates

(1) Background: Flavonoids are the primary medicinal ingredient of Saussurea involucrate, which have significant antioxidant capacity. Optimizing the extraction of Saussurea involucrate flavonoids (SIFs) and exploring the ability to block melanin deposition caused by reactive oxygen can greatly promote the development of S. involucrate whitening products. (2) Methods: Ultrasonic extraction process was optimized using the Box–Behnken design (BBD) and response surface methodology (RSM). Then, the effect of SIFs on antioxidant activity and anti-deposition of melanin, and genes related to the melanin synthesis are studied. (3) Results: The optimal extraction procedures are as follows: the extraction time, ethanol content, and solvent ratio (v/w) are 64 min, 54%, and 54:1, respectively. The reducing activity and scavenging rates of 2,2-diphenyl-1-picrylhydrazyl (DPPH), superoxide anion, hydroxyl radical, and ABTS+ were promoted as more S. involucrate flavonoid extract was added. The SIFs extract induced a decrease in the melanin synthesis by inhibiting the human melanoma A375 cell tyrosinase activity. SIFs also depress expression of melanin synthesis related genes. (4) Conclusions: the highest SIFs content was obtained by using 54% ethanol and 54:1 solvent ratio (v/w) for 64 min. The extract of SIFs exhibited good ability of antioxidant and anti-deposition of melanin in human melanocytes.

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