scholarly journals Efficient Repair of DNA Damage Induced by Heavy Ion Particles in Meiotic Prophase I Nuclei of Caenorhabditis elegans

2003 ◽  
Vol 44 (3) ◽  
pp. 271-276 ◽  
Author(s):  
TAKAKO TAKANAMI ◽  
YONGZHAO ZHANG ◽  
HIDETOSHI AOKI ◽  
TOMOKO ABE ◽  
SHIGEO YOSHIDA ◽  
...  
Keyword(s):  
Dna Damage ◽  
Caenorhabditis Elegans ◽  
Meiotic Prophase ◽  
Heavy Ion ◽  
Prophase I ◽  
Meiotic Prophase I

scholarly journals The CSN/COP9 Signalosome Regulates Synaptonemal Complex Assembly during Meiotic Prophase I of Caenorhabditis elegans

PLoS Genetics ◽  
2014 ◽  
Vol 10 (11) ◽  
pp. e1004757 ◽  
Author(s):  
Heather Brockway ◽  
Nathan Balukoff ◽  
Martha Dean ◽  
Benjamin Alleva ◽  
Sarit Smolikove
Keyword(s):  
Caenorhabditis Elegans ◽  
Synaptonemal Complex ◽  
Meiotic Prophase ◽  
Cop9 Signalosome ◽  
Complex Assembly ◽  
Prophase I ◽  
Meiotic Prophase I

scholarly journals Sister chromatid repair maintains genomic integrity during meiosis in Caenorhabditis elegans

2020 ◽  
Author(s):  
Erik Toraason ◽  
Cordell Clark ◽  
Anna Horacek ◽  
Marissa L. Glover ◽  
Alina Salagean ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Sister Chromatid ◽  
Meiotic Prophase ◽  
Genome Integrity ◽  
Early Prophase ◽  
Dna Breaks ◽  
Late Prophase ◽  
Exogenous Dna ◽  
Prophase I ◽  
Meiotic Prophase I

SummaryDuring meiosis, the maintenance of genome integrity is critical for generating viable haploid gametes [1]. In meiotic prophase I, double-strand DNA breaks (DSBs) are induced and a subset of these DSBs are repaired as interhomolog crossovers to ensure proper chromosome segregation. DSBs in excess of the permitted number of crossovers must be repaired by other pathways to ensure genome integrity [2]. To determine if the sister chromatid is engaged for meiotic DSB repair during oogenesis, we developed an assay to detect sister chromatid repair events at a defined DSB site during Caenorhabditis elegans meiosis. Using this assay, we directly demonstrate that the sister chromatid is available as a meiotic repair template for both crossover and noncrossover recombination, with noncrossovers being the predominant recombination outcome. We additionally find that the sister chromatid is the exclusive recombination partner for DSBs during late meiotic prophase I. Analysis of noncrossover conversion tract sequences reveals that DSBs are processed similarly throughout prophase I and recombination intermediates remain central around the DSB site. Further, we demonstrate that the SMC-5/6 complex is required for long conversion tracts in early prophase I and intersister crossovers during late meiotic prophase I; whereas, the XPF-1 nuclease is required only in late prophase to promote sister chromatid repair. In response to exogenous DNA damage at different stages of meiosis, we find that mutants for SMC-5/6 and XPF-1 have differential effects on progeny viability. Overall, we propose that SMC-5/6 both processes recombination intermediates and promotes sister chromatid repair within meiotic prophase I, while XPF-1 is required as an intersister resolvase only in late prophase I.

scholarly journals Exposure to the anthelmintic dinitroaniline oryzalin causes changes in meiotic prophase morphology and loss of synaptonemal complexes in the nematode Caenorhabditis elegans

2021 ◽  
Vol 2 ◽  
Author(s):  
Paul Goldstein
Keyword(s):  
Caenorhabditis Elegans ◽  
Nuclear Matrix ◽  
Meiotic Prophase ◽  
Parasitic Nematodes ◽  
Nematode Caenorhabditis Elegans ◽  
Synaptonemal Complexes ◽  
Prophase I ◽  
Meiotic Prophase I

Abstract The anthelmintic dinitroaniline oryzalin interferes with the formation of microtubules and inhibits meiosis and mitosis in nematodes. Exposure to oryzalin resulted in deterioration in morphology of the oocytes and loss of synaptonemal complexes at meiotic prophase I. The nuclear matrix and envelope were poorly formed, and the central rachis was diminished. These results provide the basis for the loss of fecundity after treatment with the oryzalin resulting in control of parasitic nematodes.

Cohesin component dynamics during meiotic prophase I in mammalian oocytes

2004 ◽  
Vol 12 (3) ◽  
pp. 197-213 ◽  
Author(s):  
Ignacio Prieto ◽  
Charles Tease ◽  
Nieves Pezzi ◽  
José M. Buesa ◽  
Sagrario Ortega ◽  
...  
Keyword(s):  
Meiotic Prophase ◽  
Prophase I ◽  
Meiotic Prophase I

scholarly journals Nuclear Envelope-Associated Chromosome Dynamics during Meiotic Prophase I

2018 ◽  
Vol 5 ◽  
Author(s):  
Xinhua Zeng ◽  
Keqi Li ◽  
Rong Yuan ◽  
Hongfei Gao ◽  
Junling Luo ◽  
...  
Keyword(s):  
Nuclear Envelope ◽  
Meiotic Prophase ◽  
Chromosome Dynamics ◽  
Prophase I ◽  
Meiotic Prophase I

scholarly journals A mutation in the endonuclease domain of mouse MLH3 reveals novel roles for MutLγ during crossover formation in meiotic prophase I

PLoS Genetics ◽  
2019 ◽  
Vol 15 (6) ◽  
pp. e1008177 ◽  
Author(s):  
Melissa Toledo ◽  
Xianfei Sun ◽  
Miguel A. Brieño-Enríquez ◽  
Vandana Raghavan ◽  
Stephen Gray ◽  
...  
Keyword(s):  
Meiotic Prophase ◽  
Prophase I ◽  
Meiotic Prophase I ◽  
Endonuclease Domain

Analysis of meiotic prophase I in live mouse spermatocytes

2008 ◽  
Vol 16 (5) ◽  
pp. 743-760 ◽  
Author(s):  
Meisha A. Morelli ◽  
Uwe Werling ◽  
Winfried Edelmann ◽  
Mark S. Roberson ◽  
Paula E. Cohen
Keyword(s):  
Meiotic Prophase ◽  
Prophase I ◽  
Meiotic Prophase I ◽  
Live Mouse

scholarly journals UHRF1-repressed 5’-hydroxymethylcytosine is essential for the male meiotic prophase I

2020 ◽  
Vol 11 (2) ◽  
Author(s):  
Hongjie Pan ◽  
Ning Jiang ◽  
Shenfei Sun ◽  
Hanwei Jiang ◽  
Jianze Xu ◽  
...  
Keyword(s):  
Meiotic Prophase ◽  
Prophase I ◽  
Meiotic Prophase I
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