scholarly journals Whole-body X-irradiation Induces Acute and Transient Expression of Heme Oxygenase-1 in Rat Liver

2002 ◽  
Vol 43 (2) ◽  
pp. 205-205 ◽  
Author(s):  
KEIKO SUZUKI ◽  
MASAHIKO MORI ◽  
FUMIHIKO KUGAWA ◽  
HIROSHI ISHIHARA
Keyword(s):  
Transient Expression ◽  
Heme Oxygenase ◽  
Rat Liver ◽  
Whole Body ◽  
Heme Oxygenase 1 ◽  
X Irradiation

Hemoglobin-Glutamer 200 Reduces Reperfusion Injury of the Cold Preserved Rat Liver by Induction of Heme Oxygenase-1

2008 ◽  
Vol 150 (2) ◽  
pp. 243-254 ◽  
Author(s):  
Stefan A. Topp ◽  
Andreas Krieg ◽  
Alexander Koch ◽  
Carina M. Tidden ◽  
Uwe Ramp ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Heme Oxygenase ◽  
Rat Liver ◽  
Heme Oxygenase 1

Stimulation of cholesterol biosynthesis from acetate in rat liver and adrenals by whole body X-irradiation

1959 ◽  
Vol 196 (6) ◽  
pp. 1231-1237 ◽  
Author(s):  
R. Gordon Gould ◽  
Virginia L. Bell ◽  
Edith H. Lilly
Keyword(s):  
Rat Liver ◽  
Adrenal Glands ◽  
Cholesterol Biosynthesis ◽  
Whole Body ◽  
Hepatic Cholesterol ◽  
Reliable Measure ◽  
Proximate Cause ◽  
Synthetic Rate ◽  
X Irradiation ◽  
Stimulation Of

Whole body x-irradiation resulted in an increased cholesterol biosynthesis in rat liver and adrenal glands, as measured by the rate of incorporation of either acetate-1-C14 or H3OH in intact animals. The effect was significant 24 hours postirradiation but was much larger at 48 hours, and was proportional to dosage over the range 300–2400 r. In liver the increase in rate was about 100%/100 r. Intestine showed no effect and carcass only a slight increase. Mice showed a small increase in hepatic cholesterol biosynthesis but rabbits and guinea pigs no significant change. Rats injected with both acetate-1-C14 and H3OH gave reasonably constant ratios of C14 and H3 in liver and carcass cholesterol in control and irradiated animals, supporting the hypothesis that the use of acetate-1-C14 in whole animals under standard conditions is a reliable measure of cholesterol biosynthetic rate. The proximate cause of the increased rate of cholesterol synthesis is postulated to be the decreased concentration; in liver a decrease of 0.12 mg/gm was correlated with a doubling of the synthetic rate.

scholarly journals Regulation of human heme oxygenase-1 gene expression under thermal stress

Blood ◽  
1996 ◽  
Vol 87 (12) ◽  
pp. 5074-5084 ◽  
Author(s):  
S Okinaga ◽  
K Takahashi ◽  
K Takeda ◽  
M Yoshizawa ◽  
H Fujita ◽  
...  
Keyword(s):  
Gene Expression ◽  
Thermal Stress ◽  
Heat Shock ◽  
Transient Expression ◽  
Reporter Gene ◽  
Heme Oxygenase ◽  
Gene Promoter ◽  
Heme Oxygenase 1 ◽  
Heat Shock Element ◽  
Hsp70 Mrna

Heme oxygenase-1 is an essential enzyme in heme catabolism, and its human gene promoter contains a putative heat shock element (HHO-HSE). This study was designed to analyze the regulation of human heme oxygenase-1 gene expression under thermal stress. The amounts of heme oxygenase-1 protein were not increased by heat shock (incubation at 42 degrees C) in human alveolar macrophages and in a human erythroblastic cell line, YN-1–0-A, whereas heat shock protein 70 (HSP70) was noticeably induced. However, heat shock factor does bind in vitro to HHO-HSE and the synthetic HHO-HSE by itself is sufficient to confer the increase in the transient expression of a reporter gene upon heat shock. The deletion of the sequence, located downstream from HHO-HSE, resulted in the activation of a reporter gene by heat shock. These results suggest that HHO-HSE is potentially functional but is repressed in vivo. Interestingly, heat shock abolished the remarkable increase in the levels of heme oxygenase-1 mRNA in YN-1–0-A cells treated with hemin or cadmium, in which HSP70 mRNA was noticeably induced. Furthermore, transient expression assays showed that heat shock inhibits the cadmium-mediated activation of the heme oxygenase-1 promoter, whereas the HSP70 gene promoter was activated upon heat shock. Such regulation of heme oxygenase-1 under thermal stress may be of physiologic significance in erythroid cells.

scholarly journals A Phosphodiesterase III Inhibitor Protects Rat Liver From Sinusoidal Obstruction Syndrome Through Heme Oxygenase-1 Induction

2009 ◽  
Vol 249 (5) ◽  
pp. 806-813 ◽  
Author(s):  
Masato Narita ◽  
Etsuro Hatano ◽  
Iwao Ikai ◽  
Aya Miyagawa-Hayashino ◽  
Atsuko Yanagida ◽  
...  
Keyword(s):  
Heme Oxygenase ◽  
Rat Liver ◽  
Heme Oxygenase 1 ◽  
Sinusoidal Obstruction Syndrome ◽  
Phosphodiesterase Iii Inhibitor ◽  
Phosphodiesterase Iii

scholarly journals Effects of Whole-body X-irradiation on the Incorporation of 3H-orotic acid into Nuclear RNA Fractions of Rat Liver

1969 ◽  
Vol 10 (1) ◽  
pp. 17-24
Author(s):  
Saburo OMATA ◽  
Shogo ICHII ◽  
Nagasumi YAGO ◽  
Shigeru KOBAYASHI
Keyword(s):  
Rat Liver ◽  
Orotic Acid ◽  
Whole Body ◽  
Nuclear Rna ◽  
X Irradiation

scholarly journals Effect of Whole-body X-irradiation on the Microsomal Drug-metabolizing Enzyme System in Rat Liver

1969 ◽  
Vol 10 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Shogo ICHII ◽  
Nagasumi YAGO ◽  
Shigeru KOBAYASHI ◽  
Saburo OMATA
Keyword(s):  
Rat Liver ◽  
Enzyme System ◽  
Whole Body ◽  
Drug Metabolizing Enzyme ◽  
X Irradiation ◽  
Metabolizing Enzyme
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