scholarly journals Differences in heavy-ion-induced DNA double-strand breaks in a mouse DNA repair-deficient mutant cell line (SL3-147) before and after chromatin proteolysis.

1995 ◽  
Vol 36 (4) ◽  
pp. 258-264 ◽  
Author(s):  
MASAHIRO MURAKAMI ◽  
KIYOMI EGUCHI-KASAI ◽  
KOKI SATO ◽  
SHINICHI MINOHARA ◽  
FUMIO YATAGAI ◽  
...  
Keyword(s):  
Dna Repair ◽  
Cell Line ◽  
Mutant Cell ◽  
Heavy Ion ◽  
Double Strand Breaks ◽  
Deficient Mutant ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Mutant Cell Line ◽  
Before And After

scholarly journals End-resection at DNA double-strand breaks in the three domains of life

2013 ◽  
Vol 41 (1) ◽  
pp. 314-320 ◽  
Author(s):  
John K. Blackwood ◽  
Neil J. Rzechorzek ◽  
Sian M. Bray ◽  
Joseph D. Maman ◽  
Luca Pellegrini ◽  
...  
Keyword(s):  
Dna Repair ◽  
Homologous Recombination ◽  
Strand Break ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Homologous Chromosomes ◽  
Domains Of Life ◽  
Strand Invasion ◽  
End Resection

During DNA repair by HR (homologous recombination), the ends of a DNA DSB (double-strand break) must be resected to generate single-stranded tails, which are required for strand invasion and exchange with homologous chromosomes. This 5′–3′ end-resection of the DNA duplex is an essential process, conserved across all three domains of life: the bacteria, eukaryota and archaea. In the present review, we examine the numerous and redundant helicase and nuclease systems that function as the enzymatic analogues for this crucial process in the three major phylogenetic divisions.

scholarly journals Increased sensitivity of subtelomeric regions to DNA double-strand breaks in a human cancer cell line

DNA Repair ◽  
2009 ◽  
Vol 8 (8) ◽  
pp. 886-900 ◽  
Author(s):  
Oliver Zschenker ◽  
Avanti Kulkarni ◽  
Douglas Miller ◽  
Gloria. E. Reynolds ◽  
Marine Granger-Locatelli ◽  
...  
Keyword(s):  
Cell Line ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Line ◽  
Double Strand Breaks ◽  
Human Cancer Cell ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Increased Sensitivity ◽  
Subtelomeric Regions

scholarly journals Recent advances in the nucleolar responses to DNA double-strand breaks

2020 ◽  
Vol 48 (17) ◽  
pp. 9449-9461
Author(s):  
Lea Milling Korsholm ◽  
Zita Gál ◽  
Blanca Nieto ◽  
Oliver Quevedo ◽  
Stavroula Boukoura ◽  
...  
Keyword(s):  
Dna Damage ◽  
Dna Repair ◽  
Dna Damage Response ◽  
Ribosomal Dna ◽  
Repetitive Sequences ◽  
Dna Lesions ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Strand Breaks ◽  
Damage Response

Abstract DNA damage poses a serious threat to human health and cells therefore continuously monitor and repair DNA lesions across the genome. Ribosomal DNA is a genomic domain that represents a particular challenge due to repetitive sequences, high transcriptional activity and its localization in the nucleolus, where the accessibility of DNA repair factors is limited. Recent discoveries have significantly extended our understanding of how cells respond to DNA double-strand breaks (DSBs) in the nucleolus, and new kinases and multiple down-stream targets have been identified. Restructuring of the nucleolus can occur as a consequence of DSBs and new data point to an active regulation of this process, challenging previous views. Furthermore, new insights into coordination of cell cycle phases and ribosomal DNA repair argue against existing concepts. In addition, the importance of nucleolar-DNA damage response (n-DDR) mechanisms for maintenance of genome stability and the potential of such factors as anti-cancer targets is becoming apparent. This review will provide a detailed discussion of recent findings and their implications for our understanding of the n-DDR. The n-DDR shares features with the DNA damage response (DDR) elsewhere in the genome but is also emerging as an independent response unique to ribosomal DNA and the nucleolus.

Heavy Ion-induced DNA Double-strand Breaks in Yeast

1992 ◽  
Vol 62 (3) ◽  
pp. 279-287 ◽  
Author(s):  
T.C. Akpa ◽  
K.J. Weber ◽  
E. Schneider ◽  
J. Kiefer ◽  
M. Frankenberg-Schwager ◽  
...  
Keyword(s):  
Heavy Ion ◽  
Double Strand Breaks ◽  
Dna Double Strand Breaks ◽  
Strand Breaks
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